27 papers · ranked by Valyu relevance
Anwar Ali, Muhammad Faisal Manzoor, Nazir Ahmad, Rana Muhammad Aadil + 7 more
'Hong Qin' 'Rabia Siddique' 'Sakhawat Riaz' 'Arslan Ahmad' 'Sameh A. Korma' 'Waseem Khalid' 'Liu Aizhong'] Cancer is a severe condition characterized by uncontrolled cell division and increasing reported mortality and diagnostic cases. In 2040, an estimated 28.4 million cancer cases are expected to happen globally. In…
Peter J Campbell, Gaddy Getz, Joshua M Stuart, Jan O Korbel + 1 more
We report the integrative analysis of more than 2,600 whole cancer genomes and their matching normal tissues across 39 distinct tumour types. By studying whole genomes we have been able to catalogue non-coding cancer driver events, study patterns of structural variation, infer tumour evolution, probe the interactions…
Kofi Boamah Mensah, Adwoa Bemah Boamah Mensah
Globally, cancer is likely to be ranked as the leading cause of death among non-communicable diseases in the 21st century. In Ghana, estimates suggest that the disease is expected to increase continuously. The best way to address the increasing burden is through a comprehensive cancer control program. This paper…
Ayoub Al-Jawaldeh, Asmus Hammerich, Faisal Abdulghafar Aldayel, Giuseppe Troisi + 15 more
'Giuseppe Troisi' 'Hanin Al-Jawaldeh' 'Hassan Aguenaou' 'Heba Alsawahli' 'Ibtihal Fadhil' 'Imen Sohaibani' 'Jalila El Ati' 'Jihan Azar' 'Lamia Mahmoud' 'Maha Barbar' 'Majid Mqbel Alkhalaf' 'Nahla Gafer' 'Taghreed Mohammed Alghaith' 'Zaynab Mahdi' 'Mandy Taktouk' 'Gea Oliveri Conti'] Cancer is one of the leading causes…
Kashvi Agarwal, Hengrui Liu
The mitotic intra-S DNA damage checkpoint signaling gene set is potentially involved in cancers where the genes play an important role. 17 total genes are involved in this gene set: ATF2, CHEK2, EME1, EME2, FANCD2, HUS1, HUS1B, MDC1, MRE11, MSH2, MUS81, NEK11, RAD17, RAD9A, RAD9B, TIPIN, XPC. The aim of this study is…
Kiara Ellis, Christopher A. Pennell
Immunotherapy is now mainstream. Advertisements are ubiquitous in print and visual media for immune based-therapies for various conditions and diseases. Smaller companies that develop novel immunotherapies are often quickly acquired by larger companies. More and more clinical trials are open for immune-based therapies…
Erik D Wold, Vaughn V Smider, Brunhilde H Felding
One of the newer classes of targeted cancer therapeutics is monoclonal antibodies. Monoclonal antibody therapeutics are a successful and rapidly expanding drug class due to their high specificity, activity, favourable pharmacokinetics, and standardized manufacturing processes. Antibodies are capable of recruiting the…
Narges Ramezani, Erfan Mohammadi
Cancer, as a complex and devastating sickness, poses a great public health challenge on a global scale. Its far-attaining impact necessitates a devoted branch of medicine referred to as oncology, which makes a specialty in the prevention, diagnosis, and treatment of cancer. In this paper, we aim to offer a complete…
Rumiana Tenchov, Aparna Sapra, Janet Sasso, Krittika Ralhan + 3 more
Cancer is one of the leading causes of death worldwide. Early cancer detection is critical because it can significantly improve treatment outcome thus saving lives, reducing suffering, and lessening psychological and economic burdens. Cancer biomarkers provide varied information about cancer, from early detection of…
Μersini Μakropoulou
In oncology, treating cancer with a beam of photons is a well established therapeutic technique, developed over 100 years, and today over 50% of cancer patients will undergo traditional X-ray radiotherapy. However, ionizing radiation therapy is not the only option, as the high-energy photons delivering their…
Thales A. F. Albuquerque, Luisa Drummond do Val, Aoife Doherty, João Pedro de Magalhães
'João Pedro de Magalhães'] Title: ABSTRACT Cancer is a disease of multicellularity; it originates when cells become dysregulated due to mutations and grow out of control, invading other tissues and provoking discomfort, disability, and eventually death. Human life expectancy has greatly increased in the last two…
Xiang-Ping Jia, Hong Sun
The fitness of somatic cells of metazoan, the ability of proliferation and survival, depends on microenvironment. In somatic evolution, a mutated cell in a tissue clonally expands abnormally because of its high fitness as normal cells in a corresponding microenvironment. In this study, we propose the cancer cell…
Manish Kumar
Cancer is a complex disease having a number of composite problems to be considered including cancer immune evasion, therapy resistance, and recurrence for a cure. Fundamentally, it remains a genetic disease as diverse aspects of the complexity of tumor growth and cancer development relate to its genetic machinery and…
Stéphane Urcun, Guillermo Lorenzo, Davide Baroli, Pierre-Yves Rohan + 4 more
'Giuseppe Sciumè' 'Wafa Skalli' 'V. Lubrano' 'Stéphane Bordas'] a Institute for Computational Engineering Sciences, Department of Engineering Sciences, Facult´e des Sciences, de la Technologie et de M´edecine, Universit´e du Luxembourg, Campus Kirchberg, Luxembourg b Institut de Biom´ecanique Humaine Georges Charpak…
Xin Li, D. Thirumalai
Heterogeneity is a hallmark of all cancers. Tumor heterogeneity is found at different levels – interpatient, intrapatient, and intratumor heterogeneity. All of them pose challenges for clinical treatments. The latter two scenarios can also increase the risk of developing drug resistance. Although the existence of tumor…
J. Roberto Romero-Arias, Guillermo Ramírez-Santiago, Jorge X. Velasco-Hernández, Laurel Ohm + 1 more
We present and analyze a growth model of an avascular tumor that considers the basic biological principles of proliferation, motility, death and genetic mutations of the cell. From a regulatory network analysis and an analysis of genomic data we identify two sets of genes-a set of six genes and a set of sixteen…
Chenchen Li, Junfeng Zhang, Pengcheng Pan, Junjie Zhang + 7 more
'Yan Wang' 'Guoping Chen' 'Pir Muhammad' 'Rui L. Reis' 'Lin Ding' 'Yanli Wang'] Title: Abstract The incidence rate of cancer is increasing year by year due to the aging of the population, unhealthy living, and eating habits. At present, surgery and medication are still the main treatments for cancer, without paying…
Alexandra R. So, Jeong Min Si, David Lopez, Matteo Pellegrini
Cancer affects millions of individuals worldwide. One shortcoming of traditional cancer classification systems is that, even for tumors affecting a single organ, there is significant molecular heterogeneity. Precise molecular classification of tumors could be beneficial in personalizing patients’ therapy and predicting…
Anuraag Bukkuri, Frederick R. Adler
Field cancerization is a process in which a normal tissue is replaced with pre-cancerous but histologically normal tissue. This transformed field can give rise to malignancy and contribute to tumor relapse. In this paper, we create a mathematical model of field cancerization from the perspective of cancer behavioral…
Ali Mousavi Fard
Cancer cell is a deadly problem which is the main cause of global death. Unfortunately, the conventional therapies like chemo/radio therapy are not viable ways to remove all of the cancer cells. Although Robotic achievements have been increased in cancer therapy, these devices do not have the decision-making ability to…
Kavita Iyer, Julian Ivanov, Rumiana Tenchov, Krittika Ralhan + 4 more
Rapid and sustained growth in the field of immuno-oncology has resulted in expansion of available scientific literature. Gaining valuable insights and establishing deep and often hidden meaningful connections in such a large body of work is the need of the hour. In this report we summarize our findings from a novel…
Ryan Miller, Sebastian Muraru, Ana Belén Malpartida, Josh Low + 7 more
Within the next twenty years, the number of cancer patients is expected to rise by 70%. Current cancer treatments still face several limitations, such as severe side effects and a high incidence of disease recurrence. Drug combination therapies are a promising strategy to achieve higher therapeutic effects while…
HACHEMI KADRI, Mesk Alshatfa, Feras Z Alsalloum, Abdelbary Elhissi + 2 more
Cancer, a global health burden, is characterized by uncontrolled cell growth and metastasis, often resulting in debilitating treatments and mortality. While conventional therapeutic strategies have improved survival rates, they are limited by challenges such as off-target toxicity and drug resistance. With their design…
Sergey N. Rumyantsev
Although it is now an obvious truism that a person's genetic makeup has a principal influence on the development of cancer, the special characteristics of the genome that determine the resistance of cancer cells and focal distribution of cancer around the body are unknown. In contrast, the origin of analogous features…
Yusuke Aoki, Jun Yamamoto, Yasunori Tome, Kazuyuki Hamada + 6 more
Methionine addiction is a fundamental and general hallmark of cancer discovered by us almost a half-century ago [Proc Natl Acad Sci U S A 73 (1976) 1523-1527]. Methionine addiction is defined as the requirement, specific for cancer cells of all types, for exogenous methionine despite the normal ability to synthesize…
Cristina Martínez-Hernández, Mariana del Carmen Aguilera-Puga, Fabien Plisson
Current cancer treatments damage healthy cells and tissues, causing short-term and long-term side effects. New treatments are desired that show greater selectivity toward cancer cells and evade the common mechanisms of multidrug resistance. Membranolytic anticancer peptides (mACPs) hold promise against cancer and…
Authors not listed
Neuroblastoma (NB) is the most common tumor of nerve tissue and is the most common cancer in babies. The oncogene MYCN gets amplified in the disease, which can be inhibited by targeting the BRD4 protein.[1] PROTAC, a protein degradation tool, is an emerging therapeutic strategy that targets disease-causing proteins.[2]…