27 papers · ranked by Valyu relevance
Ibrahim Diori Karidio, Senay Hamarat Sanlier
Background Cancer refers to a group of some of the worldwide most diagnosed and deadliest pathophysiological conditions that conquered researchers’ attention for decades and yet begs for more questions for a full comprehension of its complex cellular and molecular pathology. Main body The disease conditions are…
Björn LDM Brücher, Ijaz S Jamall
Background Carcinogenesis is widely thought to originate from somatic mutations and an inhibition of growth suppressors, followed by cell proliferation, tissue invasion, and risk of metastasis. Fewer than 10% of all cancers are hereditary; the ratio in gastric (1%), colorectal (3-5%) and breast (8%) cancers is even…
Sergey N. Rumyantsev
Humans are extraordinarily diverse in their manifestations of cancer. Affected people have many individual differences in manifestations of their cancer as well as in the grade of its expression. The shape, location, size and rate of cancer progression may be different in different individuals or in different organs as…
Sergey Rumyantsev
Cancer has become a disease of greater concern and fear among the public as it places a significant emotional and economic burden on families and governments. Despite considerable epidemiological, immunological, genomic, surgical and pharmacological efforts, the cancer epidemic continues to increasingly take its toll…
Negar Mottaghi-Dastjerdi, Abozar Ghorbani, Hamed Montazeri
Gastric cancer (GC) ranks among the most common malignancies worldwide. In our previous study, we found overexpressed genes in GC clinical samples. The goal of the current study was to find critical genes and key pathways involved in the pathogenesis of GC. Gene interactions were analyzed using STRING, and Cytoscape…
J. Roberto Romero-Arias, Guillermo Ramírez-Santiago, Jorge X. Velasco-Hernández, Laurel Ohm + 1 more
We present and analyze a growth model of an avascular tumor that considers the basic biological principles of proliferation, motility, death and genetic mutations of the cell. From a regulatory network analysis and an analysis of genomic data we identify two sets of genes-a set of six genes and a set of sixteen…
Iwona Mitrus, Ewa Bryndza, Aleksander Sochanik, Stanisław Szala
History of cancer disease models clearly illustrates the evolving nature of these concepts. Since such models undergo continual revisions and additions as a result of underlying medical research, they also tend to reorganize knowledge and allow perceiving previously unseen relationships. Growth of medical thought has…
Peter J Campbell, Gaddy Getz, Joshua M Stuart, Jan O Korbel + 1 more
We report the integrative analysis of more than 2,600 whole cancer genomes and their matching normal tissues across 39 distinct tumour types. By studying whole genomes we have been able to catalogue non-coding cancer driver events, study patterns of structural variation, infer tumour evolution, probe the interactions…
Jihye Kim, Mitsuo Sato, Jong-Whan Choi, Hyun-Won Kim + 6 more
'Jill E. Larsen' 'John D. Minna' 'Jeong-Heon Cha' 'Yangsik Jeong' 'Seok-Geun Lee'] Lung cancer is caused by combinations of diverse genetic mutations. Here, to understand the relevance of nuclear receptors (NRs) in the oncogene-associated lung cancer pathogenesis, we investigated the expression profile of the entire 48…
Ludwik Dobrzyński, Krzysztof W. Fornalski, Joanna Reszczyńska, Marek K. Janiak
'Marek K. Janiak'] This paper focuses on the analytic modelling of responses of cells in the body to ionizing radiation. The related mechanisms are consecutively taken into account and discussed. A model of the dose- and time-dependent adaptive response is considered, for two exposure categories: acute and protracted.…
Shi-Ming Tu, Louis L. Pisters, Natasha Kyprianou
Simple Summary Germ cell tumor of the testis (TGCT) teaches us that to cure cancer, we need to acquire and apply proper biological insight and clinical acumen. In 1946, about 90% of patients with metastatic TGCT died within the first year of diagnosis. Today, over 90% of the same patients are curable. This complete…
Yuxuan Zhang, Lijun Jia
Malignant tumors are defined by extraordinarily intricate pathogenic mechanisms, yet classical oncological theories remain fragmented in an "archipelagic" state—lacking a unifying framework to integrate the processes of tumor initiation, progression, metastasis, and therapeutic resistance. This theoretical disjuncture…
Xiang-Ping Jia, Hong Sun
The fitness of somatic cells of metazoan, the ability of proliferation and survival, depends on microenvironment. In somatic evolution, a mutated cell in a tissue clonally expands abnormally because of its high fitness as normal cells in a corresponding microenvironment. In this study, we propose the cancer cell…
Manish Kumar
Cancer is a complex disease having a number of composite problems to be considered including cancer immune evasion, therapy resistance, and recurrence for a cure. Fundamentally, it remains a genetic disease as diverse aspects of the complexity of tumor growth and cancer development relate to its genetic machinery and…
Hamid Teimouri, Maria Kochugaeva, Anatoly B. Kolomeisky
Cancer is a genetic disease that results from accumulation of unfavorable mutations. As soon as genetic and epigenetic modifications associated with these mutations become strong enough, the uncontrolled tumor cell growth is initiated, eventually spreading through healthy tissues. Clarifying the dynamics of cancer…
Vidhi Kulkarni, Igor Tsigelny, Valentina Kouznetsova
Feline mammary carcinoma (FMC) is a prevalent and fatal carcinoma that predominantly affects unsprayed female cats. FMC is the third most common carcinoma in cats but is still underrepresented in research. Current diagnosis methods include physical examinations, imaging tests, and fine-needle aspiration. The diagnosis…
Cristian Tomasetti, Bert Vogelstein
Introduction - Suppose an epidemiologist had discovered an industrial agent (Agent R) that was present in the normal tissues of every person in the U.S. at concentrations that were extremely highly correlated (0.80) with the risk of cancer in those tissues. And suppose this agent was shown to be highly mutagenic. S/he…
Yusuke Aoki, Jun Yamamoto, Yasunori Tome, Kazuyuki Hamada + 6 more
Methionine addiction is a fundamental and general hallmark of cancer discovered by us almost a half-century ago [Proc Natl Acad Sci U S A 73 (1976) 1523-1527]. Methionine addiction is defined as the requirement, specific for cancer cells of all types, for exogenous methionine despite the normal ability to synthesize…
Jordan Anaya
Numerous studies have identified prognostic genes in individual cancers, but a thorough pancancer analysis has not been performed. In addition, previous studies have mostly used microarray data instead of RNA-SEQ, and have not published comprehensive lists of associations with survival. Using recently available RNA-SEQ…
Kashvi Agarwal, Hengrui Liu
The mitotic intra-S DNA damage checkpoint signaling gene set is potentially involved in cancers where the genes play an important role. 17 total genes are involved in this gene set: ATF2, CHEK2, EME1, EME2, FANCD2, HUS1, HUS1B, MDC1, MRE11, MSH2, MUS81, NEK11, RAD17, RAD9A, RAD9B, TIPIN, XPC. The aim of this study is…
Chuan Dong, Ya-Wei Su, Zhen Liao, Qian Xu + 7 more
The atavistic evolutionary theory of cancer evolution highlights the role of ancient and unicell-originated genes, and comprehensive research demonstrated the evolutionary inference. Comparably, very few reports linked young genes with cancer development and maintenance. Here, we found that in cancer cell lines a…
Xin Li, D. Thirumalai
Heterogeneity is a hallmark of all cancers. Tumor heterogeneity is found at different levels – interpatient, intrapatient, and intratumor heterogeneity. All of them pose challenges for clinical treatments. The latter two scenarios can also increase the risk of developing drug resistance. Although the existence of tumor…
Ryan Miller, Sebastian Muraru, Ana Belén Malpartida, Josh Low + 7 more
Within the next twenty years, the number of cancer patients is expected to rise by 70%. Current cancer treatments still face several limitations, such as severe side effects and a high incidence of disease recurrence. Drug combination therapies are a promising strategy to achieve higher therapeutic effects while…
Arpana Parihar, Nidhi Puranik, Rekha Khandia, Raju Khan
Background: Cancer is a prominent cause of disease burden all over the world. Primary cause of the development of cancer is exposure to potentially hazardous environmental factors and unhealthy lifestyle. Among all types of cancer, breast cancer is most common in women and becomes a public health issue on a global…
Authors not listed
Immuno-oncology, a rapidly evolving field at the forefront of cancer research, leverages the body’s immune system to fight cancer. In this follow up report, we extend our natural language processing (NLP)-based analysis to pinpoint the context of emergence of the previously identified emerging concepts. To achieve this…
Rumiana Tenchov, Aparna Sapra, Janet Sasso, Krittika Ralhan + 3 more
Cancer is one of the leading causes of death worldwide. Early cancer detection is critical because it can significantly improve treatment outcome thus saving lives, reducing suffering, and lessening psychological and economic burdens. Cancer biomarkers provide varied information about cancer, from early detection of…
HACHEMI KADRI, Mesk Alshatfa, Feras Z Alsalloum, Abdelbary Elhissi + 2 more
Cancer, a global health burden, is characterized by uncontrolled cell growth and metastasis, often resulting in debilitating treatments and mortality. While conventional therapeutic strategies have improved survival rates, they are limited by challenges such as off-target toxicity and drug resistance. With their design…