29 papers · ranked by Valyu relevance
Ibrahim Diori Karidio, Senay Hamarat Sanlier
Background Cancer refers to a group of some of the worldwide most diagnosed and deadliest pathophysiological conditions that conquered researchers’ attention for decades and yet begs for more questions for a full comprehension of its complex cellular and molecular pathology. Main body The disease conditions are…
Yong Wu, Jaydutt V. Vadgama
Cancer is a global health challenge that continues to affect millions of people, despite extensive research efforts. The Special Issue on "Frontiers in Pathogenesis and Therapeutics of Cancer" presents a collection of research articles that aim to advance our understanding of cancer pathogenesis and develop targeted…
Saqib Nawaz, Wei Ho, Asif Nawaz, Sajid Ur Rahman + 6 more
This review offers an inclusive overview of current cancer treatment options. It examines emerging trends in molecular mechanisms, therapeutic challenges, and nanotechnological innovations that may significantly improve patient outcomes. Cancer is a complex disease characterized by unregulated cellular proliferation…
Emmanuel Ifeanyi Obeagu
Cervical cancer, predominantly caused by high-risk human papillomavirus (HPV) infections, continues to be a major health challenge globally. Recent research has highlighted the significant role of neutrophils, a type of white blood cell integral to the immune system, in the pathogenesis of cervical cancer. This review…
Lei Zhang, Yuan Zhang, Xin Li, Huijuan Gao + 2 more
'Peifeng Li'] Cancers, especially malignant tumors, contribute to high global mortality rates, resulting in great economic burden to society. Many factors are associated with cancer pathogenesis, including vascular endothelial growth factor-A (VEGFA) and circular RNAs (circRNA). VEGFA is a pivotal regulator of vascular…
Md Abdus Samad, Iftikhar Ahmad, Mohammad Rashid Khan, Mohd Suhail + 6 more
Breast cancer (BC) is the most prevalent cancer in women and remains the leading cause of cancer-related mortality globally. Its development is influenced by multiple factors, including genetics, environmental, aging, and modulation of various signaling pathways. The heterogeneity of BC together with the emergence of…
Sui Huang, Ana M. Soto, Carlos Sonnenschein
Genome sequencing of cancer and normal tissues, alongside single-cell transcriptomics, continues to produce findings that challenge the idea that cancer is a ‘genetic disease’, as posited by the somatic mutation theory (SMT). In this prevailing paradigm, tumorigenesis is caused by cancer-driving somatic mutations and…
Negar Mottaghi-Dastjerdi, Abozar Ghorbani, Hamed Montazeri
Gastric cancer (GC) ranks among the most common malignancies worldwide. In our previous study, we found overexpressed genes in GC clinical samples. The goal of the current study was to find critical genes and key pathways involved in the pathogenesis of GC. Gene interactions were analyzed using STRING, and Cytoscape…
Finn Ernst Olsen, Christian Liisberg
The Somatic Mutation Theory (SMT) frames cancer as a stochastic process driven by the accumulation of random mutations in somatic cells. Using a Poisson–Erlang waiting-time model, we test whether empirical mutation rates and cell-division frequencies permit such multi-hit carcinogenesis within biologically realistic…
Lucie Gourmet, Daniele Ramazzoti, Parag Mallick, Simon Walker-Samuel + 1 more
Cancer hallmarks describe key physiological characteristics that distinguish cancers from normal tissues. The temporal order in which these hallmarks appear during cancer pathogenesis is of interest from both evolutionary and clinical perspectives but has not been investigated before. Here, we order hallmarks based on…
Cassandra Burdziak, Direna Alonso-Curbelo, Thomas Walle, Francisco M. Barriga + 20 more
The response to tumor-initiating inflammatory and genetic insults can vary amongst morphologically indistinguishable cells, suggesting yet uncharacterized roles for epigenetic plasticity during early neoplasia. To investigate the origins and impact of such plasticity, we perform single-cell analyses on normal…
Tingfang Yi, Gerhard Wagner
Cancer is a leading cause of human lethality and cancer drug pan-resistant tumor metastasis (cdp-rtm) is a major source of cancer death. The integrated cytocapsular tube (CCT) networktumor system (CNTS) is essential for cancer evolution procedures including cancer cell proliferation, migration and dissemination in CCT…
Jaime Cofre
Embryology has long played a foundational role in shaping our scientific understanding of animal evolution. In recent decades, growing evidence has also highlighted its role in cancer. Despite the indisputable similarities between embryonic development and cancer, there has been limited discussion on the profound…
Anuraag Bukkuri, Frederick R. Adler
Field cancerization is a process in which a normal tissue is replaced with pre-cancerous but histologically normal tissue. This transformed field can give rise to malignancy and contribute to tumor relapse. In this paper, we create a mathematical model of field cancerization from the perspective of cancer behavioral…
Yuxuan Zhang, Lijun Jia
Malignant tumors are defined by extraordinarily intricate pathogenic mechanisms, yet classical oncological theories remain fragmented in an "archipelagic" state—lacking a unifying framework to integrate the processes of tumor initiation, progression, metastasis, and therapeutic resistance. This theoretical disjuncture…
Jean‐Pascal Capp, Benoît Aliaga, Véra Pancaldi
In cancer research, the term epigenetics was used in the 1970s in its modern sense encompassing non-genetic events modifying the chromatin state, mainly to oppose the emerging oncogene paradigm. However, starting from the establishment of this prominent concept, the importance of these epigenetic phenomena in cancer…
Manish Kumar
Cancer is a complex disease having a number of composite problems to be considered including cancer immune evasion, therapy resistance, and recurrence for a cure. Fundamentally, it remains a genetic disease as diverse aspects of the complexity of tumor growth and cancer development relate to its genetic machinery and…
Laura El Nachef, Audrey Bouchet, Michel Bourguignon, Nicolas Foray + 2 more
'Brian Gabrielli' 'Yutaka Midorikawa'] Simple Summary The current theories of carcinogenesis are the result of a long succession of thoughts and beliefs since antiquity. From the humor theory that interpreted cancer as an excess of black bile to the three notions of initiation, promotion, and progression and the most…
Frank Ernesto Alvarez, Jean Clairambault
We discuss the mathematical modelling of two of the main mechanisms which pushed forward the emergence of multicellularity: phenotype divergence in cell differentiation, and between-cell cooperation. In line with the atavistic theory of cancer, this disease being specific of multicellular animals, we set special…
Vidhi Kulkarni, Igor Tsigelny, Valentina Kouznetsova
Feline mammary carcinoma (FMC) is a prevalent and fatal carcinoma that predominantly affects unsprayed female cats. FMC is the third most common carcinoma in cats but is still underrepresented in research. Current diagnosis methods include physical examinations, imaging tests, and fine-needle aspiration. The diagnosis…
Kashvi Agarwal, Hengrui Liu
The mitotic intra-S DNA damage checkpoint signaling gene set is potentially involved in cancers where the genes play an important role. 17 total genes are involved in this gene set: ATF2, CHEK2, EME1, EME2, FANCD2, HUS1, HUS1B, MDC1, MRE11, MSH2, MUS81, NEK11, RAD17, RAD9A, RAD9B, TIPIN, XPC. The aim of this study is…
Xinyu Zhang, Vincent CS Lee, Feng Liu
Thyroid cancer, the most prevalent endocrine cancer, has gained significant global attention due to its impact on public health. Extensive research efforts have been dedicated to leveraging artificial intelligence (AI) methods for the early detection of this disease, aiming to reduce its morbidity rates. However, a…
Chuan Dong, Ya-Wei Su, Zhen Liao, Qian Xu + 7 more
The atavistic evolutionary theory of cancer evolution highlights the role of ancient and unicell-originated genes, and comprehensive research demonstrated the evolutionary inference. Comparably, very few reports linked young genes with cancer development and maintenance. Here, we found that in cancer cell lines a…
Zeyu Zhang, Yuanshen Zhao, Jingxian Duan, Yaou Liu + 4 more
learning for survival analysis Authors: ['Zeyu Zhang' 'Yuanshen Zhao' 'Jingxian Duan' 'Yaou Liu' 'Hairong Zheng' 'Dong Liang' 'Zhenyu Zhang' 'Zhicheng Li'] Abstract—The diagnosis and prognosis of cancer are typically based on multi-modal clinical data, including histology images and genomic data, due to the complex…
Ryan Miller, Sebastian Muraru, Ana Belén Malpartida, Josh Low + 7 more
Within the next twenty years, the number of cancer patients is expected to rise by 70%. Current cancer treatments still face several limitations, such as severe side effects and a high incidence of disease recurrence. Drug combination therapies are a promising strategy to achieve higher therapeutic effects while…
Arpana Parihar, Nidhi Puranik, Rekha Khandia, Raju Khan
Background: Cancer is a prominent cause of disease burden all over the world. Primary cause of the development of cancer is exposure to potentially hazardous environmental factors and unhealthy lifestyle. Among all types of cancer, breast cancer is most common in women and becomes a public health issue on a global…
Authors not listed
Immuno-oncology, a rapidly evolving field at the forefront of cancer research, leverages the body’s immune system to fight cancer. In this follow up report, we extend our natural language processing (NLP)-based analysis to pinpoint the context of emergence of the previously identified emerging concepts. To achieve this…
Rumiana Tenchov, Aparna Sapra, Janet Sasso, Krittika Ralhan + 3 more
Cancer is one of the leading causes of death worldwide. Early cancer detection is critical because it can significantly improve treatment outcome thus saving lives, reducing suffering, and lessening psychological and economic burdens. Cancer biomarkers provide varied information about cancer, from early detection of…
HACHEMI KADRI, Mesk Alshatfa, Feras Z Alsalloum, Abdelbary Elhissi + 2 more
Cancer, a global health burden, is characterized by uncontrolled cell growth and metastasis, often resulting in debilitating treatments and mortality. While conventional therapeutic strategies have improved survival rates, they are limited by challenges such as off-target toxicity and drug resistance. With their design…