18 papers · ranked by Valyu relevance
Rafaela Rodrigues, Carlos Sousa, Nuno Vale, Georgina Tzanakaki + 1 more
'Laurent Bélec'] Chlamydia is one of the most common sexually transmitted bacterial infections (STIs) worldwide. It is caused by Chlamydia trachomatis (CT), which is an obligate intracellular bacterium. In some cases, it can occur in coinfection with other parasites, increasing the pathologic potential of the…
Thomas Meyer, Eberhard Straube
The intracellular life style of chlamydia and the ability to cause persistent infections with low-grade replication requires tests with high analytical sensitivity to directly detect C. trachomatis (CT) in medical samples. Nucleic acid amplification tests (NAATs) are the most sensitive assays with a specificity similar…
Bogna Grygiel-Górniak, Barbara Anna Folga, Servaas A. Morré, Elisabetta Blasi
'Elisabetta Blasi'] Chlamydia trachomatis is an evasive pathogen that can prompt severe clinical manifestations in humans such as vaginitis, epididymitis, lymphogranuloma venereum, trachoma, conjunctivitis and pneumonia. If left untreated, chronic infections with C. trachomatis can give rise to long-lasting and even…
Rafaela Rodrigues, Ana Rita Silva, Carlos Sousa, Nuno Vale + 1 more
'Stephen G. Schwartz'] Chlamydial infections are one of the most common sexually transmitted bacterial infections worldwide, which is related to serious consequences for the mental, sexual, and reproductive health of women and men. The infection is commonly asymptomatic; consequently, screening programs for infection…
Bethan Davies, Katy M. E. Turner, Thomas Benfield, Maria Frølund + 4 more
Sexually transmitted C. trachomatis (chlamydia) is the most prevalent sexually transmitted infection (STI) with an estimated 68,455,000 incident cases globally in women in 2012 . Chlamydia is the subject of intensive control efforts in many high-income settings . The aim of diagnosing and treating chlamydia is 2-fold…
EM Harding-Esch, EC Cousins, S-LC Chow, LT Phillips + 14 more
Rapid Point-Of-Care Tests (POCTs) for Chlamydia trachomatis (CT) may reduce onward transmission and reproductive sexual health (RSH) sequelae by reducing turnaround times between diagnosis and treatment. The io^^®^^ single module system (Atlas Genetics Ltd) runs clinical samples through a microfluidic CT cartridge…
Lorraine K McDonagh, John M Saunders, Jackie Cassell, Hamad Bastaki + 2 more
'Thomas Hartney' 'Greta Rait'] Introduction Chlamydia is a key health concern with high economic and social costs. There were over 200 000 chlamydia diagnoses made in England in 2015. The burden of chlamydia is greatest among young people where the highest prevalence rates are found. Annual testing for sexually active…
Jannie J. van der Helm, Leslie O. A. Sabajo, Antoon W. Grunberg, Servaas A. Morré + 3 more
'Servaas A. Morré' 'Arjen G. C. L. Speksnijder' 'Henry J. C. de Vries' 'Deborah Dean'] Background In general, point-of-care (POC) tests for Chlamydia trachomatis (Ct) show disappointing test performance, especially disappointing sensitivity results. However, one study sponsored by the manufacturer (Diagnostics for the…
Y.Q. Li, Dewei Wang, Joshua M. Tebbs
infections among Iowa residents Authors: ['Y.Q. Li' 'Dewei Wang' 'Joshua M. Tebbs'] Summary: Group testing, a method that screens subjects in pooled samples rather than individually, has been employed as a cost-effective strategy for chlamydia screening among Iowa residents. In efforts to deepen our understanding of…
Chelsea Schafer, Belinda Prado, Nora Barin, Leslie Gama
Through extra genital screening methods, Health Departments and clinics can increase detection of sexually transmitted diseases (STDs) when used with urethral testing. Retrospective medical review of 1,571 patient health records, who received CT/GC testing, based on at least 1-visit to the Long Beach Department of…
Laura Müller, Piklu Mallick, Antonio B. Marín-Carballo, Philipp Dönges + 5 more
'Philipp Dönges' 'Robyn J. N. Kettlitz' 'Carolina J. Klett-Tammen' 'Mirjam Kretzschmar' 'Viola Priesemann' 'Seba Contreras'] HIV pre-exposure Prophylaxis (PrEP) has become essential for global HIV control, but its implementation coincides with rising bacterial STI rates among men who have sex with men (MSM). While…
Laura S. Stewart, Sandra Alvarez-Macias, Rendie McHenry, James D. Chappell + 1 more
Conventional susceptibility testing of Chlamydophila pneumoniae does not account for the complex life cycle that takes place in an obligatory intracellular niche and involves multiple morphological forms. Some of these forms (elementary bodies and cryptic bodies) cause persistence and are not susceptible to…
Joost Smid, Christian L. Althaus, Nicola Low
Mathematical modelling studies of C. trachomatis transmission predict that interventions to screen and treat chlamydia infection will reduce prevalence to a greater degree than that observed in empirical population-based studies. We investigated two factors that might explain this discrepancy: partial immunity after…
Shoulian Dong, Manuel X. Duval, Tri D. Do, Jeff Ho + 5 more
Rapid point-of-care (POC) diagnostics are essential tools for improving timely treatment and reducing the transmission of sexually transmitted infections (STIs). The STI NG Plus Assay is a rapid multiplex LAMP (loop-mediated isothermal amplification) NAAT (nucleic acid amplification test) capable of simultaneously…
Zhuolin Qu, Asma Azizi, Norine Schmidt, Megan Clare Craig-Kuhn + 3 more
'Charles Stoecker' 'James M. Hyman' 'Patricia Kissinger'] aDepartment of Mathematics, Tulane University, New Orleans, LA 70118 bDepartment of Mathematics, The University of Texas at San Antonio, San Antonio, Texas, 8249 cSimon A. Levin Mathematical Computational Modeling Science Center, Arizona State University, Tempe…
Joost Smid, Christian L. Althaus, Nicola Low, Magnus Unemo + 1 more
A new variant of Chlamydia trachomatis (nvCT) was discovered in Sweden in 2006. The nvCT has a plasmid deletion, which escaped detection by two nucleic acid amplification tests (Abbott/Roche, AR), which were used in 14 of 21 Swedish counties. The objectives of this study were to assess when and where nvCT emerged in…
Nicola Low, Janneke C. M. Heijne, Sereina A. Herzog, Christian L. Althaus
'Christian L. Althaus'] Results: In the absence of partner treatment, the medians of the expected re-infection probabilities are 19.4% (interquartile range (IQR) 9.2–31.6%) for chlamydia and 12.5% (IQR 5.6–22.2%) for gonorrhoea. If all current partners receive treatment three days after the index case, the expected…
Asma Azizi Boroojeni
Chlamydia trachomatis (Ct) is the most common bacterial sexually transmitted infection (STI) in the United States and is major cause of infertility, pelvic inflammatory disease, and ectopic pregnancy among women. Despite decades of screening women for Ct, rates continue to increase among them in high prevalent areas…