17 papers · ranked by Valyu relevance
Rafaela Rodrigues, Carlos Sousa, Nuno Vale, Georgina Tzanakaki + 1 more
'Laurent Bélec'] Chlamydia is one of the most common sexually transmitted bacterial infections (STIs) worldwide. It is caused by Chlamydia trachomatis (CT), which is an obligate intracellular bacterium. In some cases, it can occur in coinfection with other parasites, increasing the pathologic potential of the…
Nicole H. T. M. Dukers-Muijrers, Ymke J. Evers, Christian J. P. A. Hoebe, Petra F. G. Wolffs + 7 more
Background Chlamydia trachomatis (CT) is the most common bacterial sexually transmitted infection (STI) worldwide. CT is mainly asymptomatic. Test-and-treat strategies are widely implemented to prevent transmission and complications. Strategies are not without controversy in asymptomatic women and men who have sex with…
Bogna Grygiel-Górniak, Barbara Anna Folga, Servaas A. Morré, Elisabetta Blasi
'Elisabetta Blasi'] Chlamydia trachomatis is an evasive pathogen that can prompt severe clinical manifestations in humans such as vaginitis, epididymitis, lymphogranuloma venereum, trachoma, conjunctivitis and pneumonia. If left untreated, chronic infections with C. trachomatis can give rise to long-lasting and even…
Rafaela Rodrigues, Ana Rita Silva, Carlos Sousa, Nuno Vale + 1 more
'Stephen G. Schwartz'] Chlamydial infections are one of the most common sexually transmitted bacterial infections worldwide, which is related to serious consequences for the mental, sexual, and reproductive health of women and men. The infection is commonly asymptomatic; consequently, screening programs for infection…
Alison Howarth, Ana Harb, Hamish Mohammed, Fiona Burns + 9 more
'Claudia Estcourt' 'Sonja C.M. Bloch' 'Andrew Copas' "Jonathan O'Sullivan" 'Tamilore Sonubi' 'Oliver Stirrup' 'Anna Tostevin' 'John Saunders' 'Jo Gibbs'] Title: Summary Background Chlamydia is the most commonly reported sexually transmitted infection (STI) in Europe and untreated chlamydia is associated with poor…
Xu Chen, Qingxue Zhou, Yan Tan, Ronghua Wang + 5 more
Chlamydial infection, caused by Chlamydia trachomatis, is the most common bacterial sexually transmitted infection and remains a major public health problem worldwide, particularly in underdeveloped regions. Developing a rapid and sensitive point-of-care (POC) testing for accurate screening of C. trachomatis infection…
Li Zhang, Yannan Xu, Hailing Ye, Yu Xie + 7 more
Objectives This study evaluates the feasibility of a sample pooling strategy for Chlamydia trachomatis detection in pre-marital and pre-pregnancy screening in China, where pooled testing for CT remains limited despite its use in COVID-19 and HIV screening. Methods From January to May 2024, 8,142 urine samples were…
Karina Büttner, Vera Bregy, Fanny Wegner, Srinithi Purushothaman + 15 more
Rates of bacterial sexually transmitted infections (STIs) are rising and accessing their genomes provides information on strain evolution, circulating strains, and encoded antimicrobial resistance (AMR). Notable pathogens include Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Treponema pallidum (TP)…
Noah Mishkin, Rodolfo J Ricart Arbona, Sebastian E Carrasco, Samira Lawton + 7 more
Chlamydia muridarum (Cm) was detected in mice from 2 colonies with lymphoplasmacytic pulmonary infiltrates using PCR and immunohistochemistry. This discovery was unexpected as Cm infection had not been reported in laboratory mice since the 1940’s. A Cm specific PCR assay was developed and testing implemented for…
Y.Q. Li, Dewei Wang, Joshua M. Tebbs
infections among Iowa residents Authors: ['Y.Q. Li' 'Dewei Wang' 'Joshua M. Tebbs'] Summary: Group testing, a method that screens subjects in pooled samples rather than individually, has been employed as a cost-effective strategy for chlamydia screening among Iowa residents. In efforts to deepen our understanding of…
Shoulian Dong, Manuel X. Duval, Tri D. Do, Jeff Ho + 5 more
Rapid point-of-care (POC) diagnostics are essential tools for improving timely treatment and reducing the transmission of sexually transmitted infections (STIs). The STI NG Plus Assay is a rapid multiplex LAMP (loop-mediated isothermal amplification) NAAT (nucleic acid amplification test) capable of simultaneously…
Laura Müller, Piklu Mallick, Antonio B. Marín-Carballo, Philipp Dönges + 5 more
'Philipp Dönges' 'Robyn J. N. Kettlitz' 'Carolina J. Klett-Tammen' 'Mirjam Kretzschmar' 'Viola Priesemann' 'Seba Contreras'] HIV pre-exposure Prophylaxis (PrEP) has become essential for global HIV control, but its implementation coincides with rising bacterial STI rates among men who have sex with men (MSM). While…
Delia Onorini, Cory Ann Leonard, Theresa Pesch, Barbara Prähauser + 2 more
Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) cause most bacterial sexually transmitted infections (STIs) worldwide. CT/NG co-infection is more common than expected due to chance, suggesting CT/NG interaction. However, CT/NG co-infection remains largely unstudied. Obligate intracellular CT has a…
Mariam Mohagheghi, Abisola Abisoye-Ogunniyan, Angela C. Evans, Alex Peterson + 12 more
Vaccine development against Chlamydia, a prevalent sexually transmitted infection (STI), is imperative due to its global public health impact. However, significant challenges arise in the production of effective subunit vaccine based on recombinant protein antigens, particularly with membrane proteins like the Major…
Steven Hoang-Phou, Sukumar Pal, Anatoli Slepenkin, Abisola Abisoye-Ogunniyun + 9 more
Chlamydia trachomatis is the most prevalent bacterial sexually transmitted pathogen worldwide. Since chlamydial infection is largely asymptomatic with the potential for serious complications, a preventative vaccine is likely the most viable long-term answer to this public health threat. Cell-free protein synthesis…
Péter Kevei, Máté Szalai
Chlamydiae are bacteria with an interesting unusual developmental cycle. A single bacterium in its infectious form (elementary body, EB) enters the host cell, where it converts into its dividing form (reticulate body, RB), and divides by binary fission. Since only the EB form is infectious, before the host cell dies…
Hsin-Po Wang, Ryan Gabrys, Alexander Vardy
—Polymerase chain reaction (PCR) testing is the gold standard for diagnosing COVID-19. PCR amplifies the virus DNA 40 times to produce measurements of viral loads that span seven orders of magnitude. Unfortunately, the outputs of these tests are imprecise and therefore quantitative group testing methods, which rely on…