26 papers · ranked by Valyu relevance
Authors not listed
This paper presents a novel autonomous robotic assembly framework for constructing stable structures without relying on predefined architectural blueprints. Instead of following fixed plans, construction tasks are defined through targets and obstacles, allowing the system to adapt more flexibly to environmental…
Gonzalo Gabriel Méndez, Jagoda Walny, Søren Knudsen, Charles Périn + 4 more
'Samuel Huron' 'Jo Vermeulen' 'Richard Pusch' 'Sheelagh Carpendale'] Constructive approaches to visualization authoring have been shown to offer advantages such as providing options for flexible outputs, scaffolding and ideation of new data mappings, personalized exploration of data, as well as supporting data…
Andreas Wilm, Kornelia Linnenbrink, Gerhard Steger
Background Aligning homologous non-coding RNAs (ncRNAs) correctly in terms of sequence and structure is an unresolved problem, due to both mathematical complexity and imperfect scoring functions. High quality alignments, however, are a prerequisite for most consensus structure prediction approaches, homology searches…
Katrien Beuls, Paul Van Eecke
In this chapter, we argue that it is highly beneficial for the contemporary construction grammarian to have a thorough understanding of the strong relationship between the research fields of construction grammar and artificial intelligence. We start by unravelling the historical links between the two fields, showing…
Hyunsoo Chung, Jungtaek Kim, B. A. Knyazev, Jinhwi Lee + 3 more
Learning Authors: ['Hyunsoo Chung' 'Jungtaek Kim' 'B. A. Knyazev' 'Jinhwi Lee' 'Graham W. Taylor' 'Jaesik Park' 'Minsu Cho'] Discovering a solution in a combinatorial space is prevalent in many real-world problems but it is also challenging due to diverse complex constraints and the vast number of possible…
Hosam Eldeen Gasmalla, Majed Wadi, Mohamed H. Taha
This article was migrated. The article was marked as recommended. Background: Misconceptions have been observed in the application of validity by faculty and in the reporting of validity in a significant amount of published work in the field of students’ assessment. As a result, actions concerning the dissemination of…
Nassim Ataii, Sanjyot Bakshi, Yisheng Chen, Michael Fernandez + 8 more
The Construction File (CF) specification establishes a standardized interface for molecular biology operations, laying a foundation for automation and enhanced efficiency in experiment design. It is implemented across three distinct software projects: PyDNA_CF_Simulator, a Python project featuring a ChatGPT plugin for…
Klaus Zierer, Norbert M Seel
Although General Didactics (GD) and Instructional Design (ID) have not shown many points of contact in the past, there are some obvious parellels from the perspective of their historical development. This will be examined in detail in this article. More specifically, we speak about model building, which has…
Sean Lund, Vladimir Potapov, Sean R. Johnson, Jackson Buss + 1 more
Commercially synthesized genes are typically made using variations of homology-based cloning techniques, including polymerase cycling assembly from chemically synthesized microarray-derived oligonucleotides. Here we apply Data-optimized Assembly Design to the synthesis of hundreds of codon-optimized genes in both…
Ethan Jeon, Ziyang Shen, Santiago Christ, Evelyn Qi + 27 more
Custom DNA constructs have never been more common or important in the life sciences. Many researchers therefore devote substantial time and effort to molecular cloning, aided by abundant computer-aided design tools. However, support for managing and documenting the construction process, and for effectively handling and…
Jin Woo Lee, Pranav Soman, Jeong Hun Park, Shaochen Chen + 2 more
'Dong-Woo Cho' 'Tom Waigh'] Developing functional small-diameter vascular grafts is an important objective in tissue engineering research. In this study, we address the problem of compliance mismatch by designing and developing a 3D tubular construct that has a negative Poisson’s ratio νxy (NPR). NPR constructs have…
Andrew Goldberg, Kavish Kondap, Tianshuang Qiu, Zehan Ma + 6 more
Physics Simulation, and a Robot with Reset Authors: ['Andrew Goldberg' 'Kavish Kondap' 'Tianshuang Qiu' 'Zehan Ma' 'Letian Fu' 'Justin Kerr' 'Huang Huang' 'Kaiyuan Chen' 'Kuan Fang' 'Ken Goldberg'] Abstract— Generative AI systems have shown impressive capabilities in creating text, code, and images. Inspired by the…
Martin Rameš, Pavel Surynek
We propose a new approach for multi-agent collective construction, based on the idea of reversible ramps. Our ReRamp algorithm utilizes reversible side-ramps to generate construction plans for ramped block structures higher and larger than was previously possible using state-of-the-art planning algorithms, given the…
Miana Smith, Paul Arthur Richard, Alexander Htet Kyaw, Neil Gershenfeld
Although digital fabrication processes at the desktop scale have become proficient and prolific, systems aimed at producing largerscale structures are still typically complex, expensive, and unreliable. In this work, we present an approach for the fabrication of scalable macroscale structures using simple robots and…
John A. Bryant, Mason Kellinger, Cameron Longmire, Ryan Miller + 1 more
As one of the newest fields of engineering, synthetic biology relies upon a trial-and-error Design-Build-Test-Learn approach to simultaneously learn how function is encoded in biology and attempt to engineer it. Many software and hardware platforms have been developed to automate, optimize, and algorithmically perform…
Irene Shajan, Lea Rochet, Shannon Tracey, Rania Benazza + 7 more
Redirecting T cells to tumor cells by bispecific antibodies is an effective approach to treat cancer and T cell-dependent bispecific antibodies (TDBAs) are an emerging class of potent immunotherapeutic agents. By simultaneously targeting antigens on tumor cells and that on T cells, T cells are activated to kill tumor…
Holger Diessel
Usage-based linguists and psychologists have produced a large body of empirical results suggesting that linguistic structure is derived from language use. However, while researchers agree that these results characterize grammar as an emergent phenomenon, there is no consensus among usage-based scholars as to how the…
Barend Prinsloo, Gerrit van der Waldt
Political risk is identified as a dominant risk category of disaster risk management (DRM) which could negatively affect the success of those measures implemented to reduce disaster risk. Key to political risk is the construct of national identity which, if poorly constructed, could greatly contribute to political…
Jacob Mejlsted, Erik Kubaczka, Sebastian Wirth, Heinz Koeppl
Genetic circuits are a cornerstone of synthetic biology, enabling programmable control of cellular behavior for applications in health, sustainability, and biotechnology. While Genetic Design Automation (GDA) tools have optimized and streamlined the design of such circuits, rapid and efficient assembly of DNA remains a…
Authors not listed
While virtual libraries of synthetically accessible compounds have exploded in size to many billions, our capacity to extract valuable drug leads from these vast databases remains limited by computational resources. To overcome this, we developed SLICE SMARTS and Logic In ChEmistry), a powerful new tool designed for…
Michael Kimmel, Camilla Groth
An affordance perspective highlights how resourceful the ecology is for creative actions of all sorts; it captures how creativity is grounded in materiality. In contrast to “canonical affordances” (i.e., “ready-to-hand,” mundane instances), creative affordances point to unconventional or surprising action opportunities…
Noah Kleinschmidt, Thomas Lemmin
In recent years computational methods for molecular modeling have become a prime focus of computational biology and cheminformatics. Many dedicated systems exist for modeling specific classes of molecules such as proteins or small drug-like ligands. These are often heavily tailored toward the automated gen- eration of…
Javier Santos-Moreno, Yolanda Schaerli
Synthetic gene circuits emerge from iterative design-build-test cycles. Most commonly, the time-limiting step is the circuit construction process. Here, we present a hierarchical cloning scheme based on the widespread Gibson assembly method and make the set of constructed plasmids freely available. Our two-step modular…
Authors not listed
Genetic Algorithms are a powerful method to solve optimization problems with complex cost functions over vast search spaces that rely in particular on recombining parts of previous solutions. Crossover operators play a crucial role in this context. Here, we describe a large class of these operators designed for…
Benjamin Ries, Richard J Gowers, James RB Eastwood, Irfan Alibay + 4 more
Alchemical free energy campaigns can be planned using graph theory by building up networks that contain nodes representing molecules that are connected by possible transformations as edges. We introduce Konnektor, an open-source Python package, for systematically planning, modifying, and analyzing free energy…
Dariia Yehorova, Rory Crean, Peter Kasson, Shina Caroline Lynn Kamerlin
Protein structure (and thus function) is dictated by non-covalent interaction networks. These can be highly evolutionarily conserved across protein families, the members of which can diverge in sequence and evolutionary history. Here we present KIN, a tool to identify and analyze conserved non-covalent interaction…