20 papers · ranked by Valyu relevance
Waleed Elsegeiny, Kieren A. Marr, Peter R. Williamson
Cryptococcal meningoencephalitis is responsible for upwards of 15% of HIV-related deaths worldwide and is currently the most common cause of non-viral meningitis in the US, affecting both previously healthy and people with immune suppression caused by cancer chemotherapy, transplantation, and biologic therapies.…
Oscar Zaragoza
Among fungal pathogens, Cryptococcus neoformans has gained great importance among the scientific community of several reasons. This fungus is the causative agent of cryptococcosis, a disease mainly associated to HIV immunosuppression and characterized by the appearance of meningoencephalitis. Cryptococcal meningitis is…
Chen Yang, Yemei Huang, Yangyu Zhou, Xuelei Zang + 4 more
'Yitong Liu' 'Dingxia Shen' 'Xinying Xue'] Cryptococcus is an invasive fungus that seriously endangers human life and health, with a complex and well-established immune-escaping mechanism that interferes with the function of the host immune system. Cryptococcus can attenuate the host’s correct recognition of the fungal…
JULIAN Julian, ADAWIYAH Robiatul, WAHDINI Sri
Global mycosis is still a problem. One of these is the cryptococcal disease. A systemic mycosis brought on by Cryptococcus is called cryptococcosis. Host immunological conditions influence infection with Cryptococcosis. When environmental spores are inhaled by the host, the spores get to the lungs, an infection is…
Joseph M. Bednarek, Jessica C. S. Brown, Marcio Rodrigues
As healthcare improves and our ability to support patients with compromised immune systems increases, such patients become more vulnerable to microbes in the environment. These include fungal pathogens such as Cryptococcus neoformans, the primary cause of fungal meningitis and a top priority pathogen on the World…
Ankur Ankur, Jayasubba Reddy Yarava, Isha Gautam, Faith J. Scott + 8 more
Cryptococcus species are major fungal pathogens responsible for life-threatening infections in approximately a million individuals globally each year, with alarmingly high mortality rates. These fungi are distinguished by a distinctive cell wall architecture further reinforced by two virulence-associated layers…
Julia C. V. Reuwsaat, Daniel P. Agustinho, Heryk Motta, Holly Brown + 4 more
Cryptococcus neoformans is a ubiquitous, opportunistic fungal pathogen that kills almost 200,000 people worldwide each year. It is acquired when mammalian hosts inhale the infectious propagules; these are deposited in the lung and, in the context of immunocompromise, may disseminate to the brain and cause lethal…
Authors not listed
[krip′′ to-kok′əs ne′′o for-mənz], from the Greek-krypto (hidden), kokkos (berry), neos (new); and Latin-forma (form) C. neoformans is an encapsulated yeastlike fungus of the family Cryptococcaceae. It was first described in 1894 by German pathologist Otto Busse, who observed the cells in a tumor from the tibia of a…
Chrissy M. Leopold Wager, Camaron R. Hole, Karen L. Wozniak, Floyd L. Wormley Jr.
'Floyd L. Wormley Jr.'] Cryptococcus neoformans and C. gattii are fungal pathogens that cause life-threatening disease. These fungi commonly enter their host via inhalation into the lungs where they encounter resident phagocytes, including macrophages and dendritic cells, whose response has a pronounced impact on the…
Sainamthip Rangdist, Ekkasit Kanklang, Natchaya Pakdeesiriwong, Watsana Penkhrue + 7 more
The cryptococcal Amt family of ammonium transporters have been identified from our previous studies as one of the most highly upregulated proteins during transmigration in an in vitro blood-brain barrier (BBB) model, however, the role of this gene family has never been reported. Therefore, this study aimed to…
Christopher J. Winski, Peter V. Stuckey, Armando M. Marrufo, Robbi L. Ross + 3 more
Cryptococcus neoformans is an opportunistic fungal pathogen responsible for >150,000 deaths every year with a mortality rate as high as 81%. This high medical burden is due, in part, to an incomplete understanding of its pathogenesis. In a previous study, we identified a cryptococcal atypical pleiotropic drug…
Hiu Ham Lee, Dylan J. Carmichael, Victoria Ríbeiro, Dana N. Parisi + 11 more
The encapsulated fungus Cryptococcus neoformans is the most common cause of fungal meningitis, with the highest rate of disease in patients with AIDS or immunosuppression. This microbe enters the human body via inhalation of infectious particles. C. neoformans capsular polysaccharide, in which the major component is…
Vishal Midya, Ulhaas Shankar Chakraborty
A total of 50 patients were enrolled in the study, and MRI brain with MR spectroscopy was done. Out of these, 35 were HIV positive patients (cases). 15 patients with HIV negative status who also underwent MRI for unrelated pathologies were enrolled as controls. They also underwent MRI brain with MR spectroscopy.…
Katherine Pline, Simon A. Johnston
Cryptococcus neoformans is a facultative intracellular pathogenic yeast which causes cryptococcal meningitis. Infection most commonly occurs via the lungs in humans and is cleared without clinical signs in the immunocompetent, but may cause life-threatening infection in immunocompromised. C. neoformans can be…
Bruno L. Travi
Results. The literature search identified 12 antihistamines with activity against different pathogens. Eight molecules were second-generation antihistamines with intrinsically lower tendency to cross the blood brain barrier thereby with reduced side effects. Only five antihistamines had in vivo evaluations in rodents…
Authors not listed
The rise of fungal infections has become a pressing global health concern, affecting millions and leading to significant mortality, particularly among immunocompromised individuals. While antifungal treatments have played a crucial role in managing these infections, the increasing prevalence of resistant strains…
Angelo Frei, Alysha G. Elliott, Alex Kan, Hue Dinh + 24 more
There are currently fewer than ten antifungal drugs in clinical development, but new fungal strains, which are resistant to most current antifungals are spreading rapidly across the world. To prevent a second resistance crisis, new classes of antifungal drugs are urgently needed. Metal complexes have proven to be…
Indra Roux, Simon Bowles, John A. Kalaitzis, Daniel Vuong + 3 more
Chemical exploration of the recently described Australian fungus, Aspergillus burnettii, uncovered a new metabolite, burnettiene A. Here, we characterise the structure of burnettiene A as a polyene-decalin polyketide. Bioinformatic analysis of the genome of A. burnettii identified a putative biosynthetic gene cluster…
Mohamed Sebak, Fatma Molham, Mohamed A. Tammam, Amr El-Demerdash
Marine microorganisms took excessive attention as prolific producers of structurally unique secondary metabolites, offering a promising potential as substitutes or conjugates for the current therapeutics. Given the fact that various fungal species have the potential to produce secondary metabolites, only a small share…
Lydie Kerdraon, Valérie Laval, Frédéric Suffert
The negative contribution of crop residues as a source of inoculum for plant diseases is well established. However, microbial ecologists have long reported positive effects of residues on the stability of agrosystems and conservation tillage practices have become increasingly widespread. Most studies have suggested…