24 papers · ranked by Valyu relevance
Daniel P Agustinho, Liza C Miller, Lucy X Li, Tamara L Doering
neoformans Authors: ['Daniel P Agustinho' 'Liza C Miller' 'Lucy X Li' 'Tamara L Doering'] Cryptococcus neoformans is an opportunistic fungal pathogen that is ubiquitous in the environment. It causes a deadly meningitis that is responsible for over 180,000 deaths worldwide each year, including 15% of all AIDS-related…
Lilit Aslanyan, David A. Sanchez, Silvana Valdebenito, Eliseo A. Eugenin + 3 more
Cryptococcus neoformans is an encapsulated yeast-like fungus capable of causing life threatening meningoencephalitis in patients with impaired immunity. This microbe primarily infects the host via inhalation but has the ability to disseminate to the central nervous system (CNS) either as a single cell or inside of…
Jananishree Sathiyamoorthy, Jayapradha Ramakrishnan
The study investigates global genomic surveillance of Cryptococcus neoformans over three decades to elucidate genetic diversity, incorporating serotypes, molecular types, STs and mating types, phylogenomics, virulence-associated determinants, antifungal resistance, and pangenome profiles. Across 139 study genomes, the…
Authors not listed
[krip′′ to-kok′əs ne′′o for-mənz], from the Greek-krypto (hidden), kokkos (berry), neos (new); and Latin-forma (form) C. neoformans is an encapsulated yeastlike fungus of the family Cryptococcaceae. It was first described in 1894 by German pathologist Otto Busse, who observed the cells in a tumor from the tibia of a…
S. Satish, R. Rajesh, S. Shashikala, G. Kurian + 1 more
While meningoencephalitis due to cryptococcus is well known in immunocompromised patients, disseminated cryptococcosis and cryptococcemia is rare outside the setting of advanced HIV infection. We report a case of disseminated cryptococcosis occurring in a patient with Wegener’s granulomatosis on immunosuppressive…
Maphori Maliehe, Mathope A. Ntoi, Shayanki Lahiri, Olufemi S. Folorunso + 3 more
'Olufemi S. Folorunso' 'Adepemi O. Ogundeji' 'Carolina H. Pohl' 'Olihile M. Sebolai'] The ability of microorganisms to colonise and display an intracellular lifestyle within a host body increases their fitness to survive and avoid extinction. This host-pathogen association drives microbial evolution, as such organisms…
Bramantono Bramantono, Ahmad Danial, Usman Hadi
Cryptococcosis is the most common fungal disease in HIV-infected persons. It is known as the AIDS-defining illness for 60-70% of HIV-infected patients. Before antiretroviral therapy (ARV) was discovered, fungal and other opportunistic infections were a major problem for people with advanced HIV/AIDS. Presented here is…
Kennedy Kassaza, Fredrickson Wasswa, Kirsten Nielsen, Joel Bazira + 1 more
'Brian L. Wickes'] Cryptococcal meningoencephalitis, a disease with poor patient outcomes, remains the most prevalent invasive fungal infection worldwide, accounting for approximately 180,000 deaths each year. In several areas of sub-Saharan Africa with the highest HIV prevalence, cryptococcal meningitis is the leading…
Bashir Sirag, El-Shiekh Khidir, Mohammed Dumyati, Basam Sindi + 3 more
'Mahir Alsinnari' 'Hani Faidah' 'Abdalla Ahmed'] The prevalent variants of Cryptococcus neoformans, and other Cryptococcus species in pigeon excreta in Western Region of Saudi Arabia were studied. Ninety pigeon dropping samples were plated directly on Niger seed agar, and suspected colonies were sequenced using…
Corinne Maufrais, Luciana de Oliveira, Rafael W. Bastos, Frédérique Moyrand + 7 more
The genome of a large number of Cryptococcus neoformans isolates has been sequenced and analyzed in recent years. These genomes have been used to understand the global population structure of this opportunistic pathogen. However, only a small number of South American isolates have been considered in these studies, and…
Julia C. V. Reuwsaat, Daniel P. Agustinho, Heryk Motta, Holly Brown + 4 more
Cryptococcus neoformans is a ubiquitous, opportunistic fungal pathogen that kills almost 200,000 people worldwide each year. It is acquired when mammalian hosts inhale the infectious propagules; these are deposited in the lung and, in the context of immunocompromise, may disseminate to the brain and cause lethal…
Glauber R. de S. Araújo, Carolina de L. Alcantara, Noêmia Rodrigues, Wanderley de Souza + 2 more
Cryptococcus neoformans is a fungal pathogen that causes life-threatening infections in immunocompromised individuals. It is surrounded by three concentric structures that separate the cell from the extracellular space: the plasma membrane, the cell wall and the polysaccharide capsule. Although several studies have…
Hiu Ham Lee, Dylan J. Carmichael, Victoria Ríbeiro, Dana N. Parisi + 11 more
The encapsulated fungus Cryptococcus neoformans is the most common cause of fungal meningitis, with the highest rate of disease in patients with AIDS or immunosuppression. This microbe enters the human body via inhalation of infectious particles. C. neoformans capsular polysaccharide, in which the major component is…
Sainamthip Rangdist, Ekkasit Kanklang, Natchaya Pakdeesiriwong, Watsana Penkhrue + 7 more
The cryptococcal Amt family of ammonium transporters have been identified from our previous studies as one of the most highly upregulated proteins during transmigration in an in vitro blood-brain barrier (BBB) model, however, the role of this gene family has never been reported. Therefore, this study aimed to…
Vishal Midya, Ulhaas Shankar Chakraborty
A total of 50 patients were enrolled in the study, and MRI brain with MR spectroscopy was done. Out of these, 35 were HIV positive patients (cases). 15 patients with HIV negative status who also underwent MRI for unrelated pathologies were enrolled as controls. They also underwent MRI brain with MR spectroscopy.…
Thanh Tuan Lam, Dena Toffaletti, Jennifer Tenor, Charles Giamberardino + 14 more
Most cryptococcal meningitis cases occur in immunocompromised individuals and are caused by Cryptococcus neoformans var.grubii. We previously reported cryptococcal meningitis in Vietnam arising atypically in HIV-uninfected, apparently immunocompetent patients, caused by a single amplified fragment length polymorphism…
Yueru Tian, Tong Zhang, Jian Guo, Huijun Lu + 5 more
Cryptococcal meningitis (CM) is a global threat with significant attributable morbidity and mortality. Information on integrated detection for CM diagnosis is still limited. This is mainly due to the presence of a large polysaccharide capsule and the tough cell wall of Cryptococcus, which makes it difficult to extract…
Bruno L. Travi
Results. The literature search identified 12 antihistamines with activity against different pathogens. Eight molecules were second-generation antihistamines with intrinsically lower tendency to cross the blood brain barrier thereby with reduced side effects. Only five antihistamines had in vivo evaluations in rodents…
Authors not listed
The rise of fungal infections has become a pressing global health concern, affecting millions and leading to significant mortality, particularly among immunocompromised individuals. While antifungal treatments have played a crucial role in managing these infections, the increasing prevalence of resistant strains…
Divakar Badal, Aloke Kumar, Varsha Singh, Danny Raj M
Microbial interactions regulate their spread and survival in competitive environments. It is not clear if the physical parameters of the environment regulate the outcome of these interactions. In this work, we show that the opportunistic pathogen Pseudomonas aeruginosa occupies a larger area on the substratum in the…
Angelo Frei, Alysha G. Elliott, Alex Kan, Hue Dinh + 24 more
There are currently fewer than ten antifungal drugs in clinical development, but new fungal strains, which are resistant to most current antifungals are spreading rapidly across the world. To prevent a second resistance crisis, new classes of antifungal drugs are urgently needed. Metal complexes have proven to be…
Indra Roux, Simon Bowles, John A. Kalaitzis, Daniel Vuong + 3 more
Chemical exploration of the recently described Australian fungus, Aspergillus burnettii, uncovered a new metabolite, burnettiene A. Here, we characterise the structure of burnettiene A as a polyene-decalin polyketide. Bioinformatic analysis of the genome of A. burnettii identified a putative biosynthetic gene cluster…
Authors not listed
Endophytic fungus are widely distributed in medicinal plants and the Penicillium species that recovered from plant tissues directly provide an attractive resource of structurally and biologically diverse natural products. For the sake of clarity, in this review only Penicillium strains derived from medicinal plants are…
Mohamed Sebak, Fatma Molham, Mohamed A. Tammam, Amr El-Demerdash
Marine microorganisms took excessive attention as prolific producers of structurally unique secondary metabolites, offering a promising potential as substitutes or conjugates for the current therapeutics. Given the fact that various fungal species have the potential to produce secondary metabolites, only a small share…