20 papers · ranked by Valyu relevance
Priya Lakshmi Narayanan, Shan E Ahmed Raza, Allison H. Hall, Jeffrey R. Marks + 8 more
Despite increasing evidence supporting the clinical relevance of tumour infiltrating lymphocytes (TILs) in invasive breast cancer, TIL spatial distribution pattern surrounding ductal carcinoma in situ (DCIS) and its association with progression is not well understood. To characterize the tissue microecology of DCIS, we…
Colin Wu, Alison Bartak, Ramaswamy Sharma
Ductal carcinoma in situ (DCIS) accounts for approximately 25% of new breast cancer diagnoses and carries a 20% to 50% risk of post-surgical upstaging to invasive cancer, complicating risk stratification and raising concerns about overtreatment. Mammography, the primary imaging modality, is limited by low sensitivity…
Stephen W Duffy, Amanda Dibden, Dimitrios Michalopoulos, Judith Offman + 14 more
Title: Summary Background The value of screen detection and treatment of ductal carcinoma in situ (DCIS) is a matter of controversy. At present, the extent to which the diagnosis and treatment of DCIS could prevent the occurrence of invasive breast cancer in the future is not clear. We sought to estimate the…
Mohammed Badruddoja
Ductal carcinoma in situ (DCIS) of the breast is a heterogeneous neoplasm with invasive potential. Risk factors include age, family history, hormone replacement therapy, genetic mutation, and patient lifestyle. The incidence of DCIS has increased due to more widespread use of screening and diagnostic mammography…
Corrado Chiappa, Alice Bonetti, Giulio Jad Jaber, Valentina De Berardinis + 6 more
'Valentina De Berardinis' 'Veronica Bianchi' 'Francesca Rovera' 'Adam E. Frampton' 'Oreste D. Gentilini' 'Thorsten Kuehn' 'Maria Luisa Gasparri'] Simple Summary Ductal carcinoma in situ (DCIS) accounts for 20 to 25% of all breast cancers and its incidence of progression to invasive ductal carcinoma is at least 13 to…
Brian L. Sprague, Shuai Chen, Diana L. Miglioretti, Charlotte C. Gard + 5 more
The results of this cohort study suggest that DCIS detection rates on mammography screening vary by screening interval and clinical risk factors. Cumulative risk of screen-detected DCIS after 6 years of annual screening is substantially higher than for women undergoing 3 biennial screens. Age, first-degree family…
Suzanne C. Wetstein, Nikolas Stathonikos, Josien P. W. Pluim, Yujing J. Heng + 4 more
'Yujing J. Heng' 'Natalie D. ter Hoeve' 'Celien P.H. Vreuls' 'P. J. van Diest' 'Mitko Veta'] Ductal carcinoma in situ (DCIS) is a non-invasive breast cancer that can progress into invasive ductal carcinoma (IDC). Studies suggest DCIS is often overtreated since a considerable part of DCIS lesions may never progress into…
Zhe Zhu, Michael R. Harowicz, Jun Zhang, Ashirbani Saha + 3 more
'Lars J. Grimm' 'E. Shelley Hwang' 'Maciej A. Mazurowski'] Material and Methods: In this institutional review board-approved study, we analyzed dynamic contrast-enhanced fat-saturated T1-weighted MRI sequences of 131 patients at our institution with a core needle biopsy-confirmed diagnosis of DCIS. The patients had no…
Lotte E. Elshof, Michael Schaapveld, Emiel J. Rutgers, Marjanka K. Schmidt + 3 more
'Marjanka K. Schmidt' 'Linda de Munck' 'Flora E. van Leeuwen' 'Jelle Wesseling'] Background Population screening with mammography has resulted in increased detection of ductal carcinoma in situ (DCIS). The aim of this population-based cohort study was to assess whether the method of detection should be considered when…
Babak Ehteshami Bejnordi, Guido Zuidhof, Maschenka Balkenhol, Meyke Hermsen + 5 more
'Meyke Hermsen' 'Peter Bult' 'Bram van Ginneken' 'Nico Karssemeijer' 'Geert Litjens' 'Jeroen van der Laak'] Abstract. Automated classification of histopathological whole-slide images (WSI) of breast tissue requires analysis at very high resolutions with a large contextual area. In this paper, we present context-aware…
Ali Almutairy, Abdullah Alhamed, Stephen G. Grant, Miranda J. Sarachine Falso + 3 more
Breast cancer (BC) is the most common cancer affecting women in the United States. Ductal carcinoma in situ (DCIS) is the earliest identifiable pre-invasive BC lesion. Estimates show that 14 to 50% of DCIS cases progress to invasive BC. Our objective was to identify nuclear matrix proteins (NMP) with specifically…
Alexa Glencer, Kirithiga Ramalingam, Nicole Schindler, Hidetoshi Mori + 14 more
Ductal carcinoma in situ (DCIS) constitutes an array of morphologically recognized intraductal neoplasms in the mammary ductal tree defined by an increased risk for subsequent invasive carcinomas at or near the site of biopsy detection. However, only 15-45% of untreated DCIS cases progress to invasive cancer, so…
Ping Ren
In order to investigate the breast cancer prediction problem on the aging population with the grades of DCIS, we conduct a tree augmented naive Bayesian network experiment trained and tested on a large clinical dataset including consecutive diagnostic mammography examinations, consequent biopsy outcomes and related…
Poulmi Banerjee, Satadal Saha
and stage of Breast Tumor Authors: ['Poulmi Banerjee' 'Satadal Saha'] Abstract— Breast cancer is described as one of the most common types of cancer which has been diagnosed mainly in women. When compared in the ratio of male to female, it has been duly found that the prone of having breast cancer is more in females…
Noor Nakhaei, Chrysostomos Marasinou, Akinyinka Omigbodun, Nina Capiro + 3 more
Towards Improved Characterization of Suspicious Microcalcifications Authors: ['Noor Nakhaei' 'Chrysostomos Marasinou' 'Akinyinka Omigbodun' 'Nina Capiro' 'Bo Li' 'Anne Hoyt' 'William Hsu'] Accurate characterization of suspicious microcalcifications is critical to determine whether these calcifications are associated…
Akash Modi, Sumit Kumar Jha, Purnendu Mishra, Rajiv Kumar + 3 more
Cancer Image Segmentation Authors: ['Akash Modi' 'Sumit Kumar Jha' 'Purnendu Mishra' 'Rajiv Kumar' 'Kiran Aatre' 'Gursewak Singh' 'Shubham Mathur'] Digital pathology and microscopy image analysis are widely employed in the segmentation of digitally scanned IHC slides, primarily to identify cancer and pinpoint regions…
Leslie Solorzano, Stephanie Robertson, Johan Hartman, Mattias Rantalainen
Accurate detection of invasive breast cancer (IC) can provide decision support to pathologists as well as improve downstream computational analyses, where detection of IC is a first step. Tissue containing IC is characterized by the presence of specific morphological features, which can be learned by convolutional…
Pooja V. Gaikwad, Nazifa Rahman, Pratyusha Ghosh, Dianna Ng + 1 more
Breast cancer is a substantial source of morbidity and mortality worldwide. It is particularly more difficult to treat at later stages, and treatment regimens depend heavily on both staging and the molecular subtype of the tumor. However, both detection and molecular analyses rely on standard imaging and histological…
Rumiana Tenchov, Aparna Sapra, Janet Sasso, Krittika Ralhan + 3 more
Cancer is one of the leading causes of death worldwide. Early cancer detection is critical because it can significantly improve treatment outcome thus saving lives, reducing suffering, and lessening psychological and economic burdens. Cancer biomarkers provide varied information about cancer, from early detection of…
Daniel P. Salem, Laura T. Bortolin, Dan Gusenleitner, Jonian Grosha + 17 more
Detection of cancer early, when it is most treatable, remains a significant challenge due to the lack of diagnostic methods sufficiently sensitive to detect nascent tumors. Early-stage tumors are small relative to their tissue of origin, heterogeneous, and infrequently manifest in clinical symptoms. Detection of their…