14 papers · ranked by Valyu relevance
LO Mendonca, L Malle, FX Donavan, SC Chandrasekharappa + 5 more
'GA Montealegre' 'D Chapelle' 'D Suri' 'R Goldbach-Mansky' 'AA de Jesus'] Introduction Deficiency of interleukin-1-receptor antagonist (DIRA) is a rare autoinflammatory disease clinically characterized by early-onset generalized pustulosis, multifocal osteomyelitis and elevation of acute-phase reactants. DIRA is caused…
Abanoub Ghobrial, Kerstin Eder
In this paper, we give an overview of a recently developed method for dynamic domain adaptation, named DIRA, which relies on a few samples in addition to a regularisation approach, named elastic weight consolidation, to achieve state-of-the-art (SOTA) domain adaptation results. DIRA has been previously shown to perform…
Abanoub Ghobrial, Xuan Zheng, Darryl Hond, Hamid Asgari + 1 more
'Kerstin Eder'] Abstract. Autonomous systems (AS) often use Deep Neural Network (DNN) classifiers to allow them to operate in complex, high-dimensional, non-linear, and dynamically changing environments. Due to the complexity of these environments, DNN classifiers may output misclassifications during operation when…
A Berdeli, B Sözeri, B Gerceker Türk, A Oz + 1 more
Introduction Deficiency of the interleukin-1 receptor antagonist (DIRA)(OMIM 612852) is a recently described rare autoinflammatory and autosomal recessive disease, caused by loss of function mutations in interleukin-1-receptor antagonist gene (IL1RN) leading to the unopposed activation of the IL-1 pathway. The human…
Adrian Redder, Arunselvan Ramaswamy, Daniel E. Quevedo
This work considers the problem of control and resource allocation in networked systems. To this end, we present DIRA a Deep reinforcement learning based Iterative Resource Allocation algorithm, which is scalable and control-aware. Our algorithm is tailored towards large-scale problems where control and scheduling need…
Maria Magnusson, Michael Sandborg, Åsa Carlsson Tedgren, Alexandr Malusek
Accurate computed tomography (CT) numbers derived from dual-energy CT (DECT) have numerous applications, including optimising the precision of radiation treatment planning. The dual-energy iterative reconstruction algorithm (DIRA) utilizes material decomposition in the iterative loop to generate monoenergetic images…
Fatemeh Haghighi, Mohammad Reza Hosseinzadeh Taher, Michael B. Gotway, Jianming Liang
'Jianming Liang'] Discriminative learning, restorative learning, and adversarial learning have proven beneficial for self-supervised learning schemes in computer vision and medical imaging. Existing efforts, however, omit their synergistic effects on each other in a ternary setup, which, we envision, can significantly…
Yandie Li, Meiping Yu, Meiping Lu
Background Systemic autoinflammatory diseases (SAIDs) are hyperinflammatory and immune-dysregulation conditions that present in childhood. This kind of disease is a rare disease with early-onset, severe condition and difficult diagnosis, which seriously affects the growth and development of children. Most children need…
Elena Urbaneja, Nuria Bonet, Manuel Solis-Moruno, Anna Mensa-Vilaro + 8 more
'Iñaki Ortiz de Landazuri' 'Marc Tormo' 'Rocio Lara' 'Susana Plaza' 'Virginia Fabregat' 'Jordi Yagüe' 'Ferran Casals' 'Juan I. Arostegui'] Undiagnosed monogenic diseases represent a challenging group of human conditions highly suspicious to have a genetic origin, but without conclusive evidences about it. We identified…
Kathryn Pillai, Joshua Pillai, Jun Ling, Ferdinando Nicoletti
Background. Deficiency of interleukin-1 receptor antagonist (DIRA) is a rare life-threatening autosomal recessive autoinflammatory disease with symptoms including but not limited to osteomyelitis, periostitis, and systemic inflammation. DIRA is developed from the loss-of-function biallelic mutations of the IL1RN gene…
Taojun Wang, Saeed Ahmad, Raissa Santos de Lima Rosa, Briawna Binion + 17 more
While overlooked during the Human Microbiome Project, characterizing the urinary microbiota in health and disease is a new frontier in microbiome science. Recent studies have associated differential abundance of bacterial taxa including Propionimicrobium lymphophilum and Actinobaculum/Actinotignum spp. with prostate…
Inoshita, Keito
Driver distraction behavior recognition using in-vehicle cameras demands real-time inference on edge devices. However, lightweight models often fail to capture fine-grained behavioral cues, resulting in reduced performance on unseen drivers or under varying conditions. ROI-based methods also increase computational…
Stéphanie Marsin, Sylvain Jeannin, Sonia Baconnais, Hélène Walbott + 8 more
The loading of the bacterial replicative helicase is an essential step for genome replication and depends on the assistance of accessory proteins. Several of these proteins have been identified across the bacterial phyla. DciA is the most common loading protein in bacteria, yet the one whose mechanism is the least…
Rui Zhang, Somaieh Ahmadian, Jolanda Piepers, Florian Bock + 2 more
Notch receptor activation requires γ-secretase-mediated release of Notch intracellular domain 1(NICD1) to regulate gene transcription. Here, we identify the proton-driven Solute carrier 11A2 (Slc11A2) or divalent metal transport protein Dmt1 as an inhibitor of Notch signaling via regulating iron homeostasis and…