30 papers · ranked by Valyu relevance
Alexandre Maes, Jeanne Le Peillet, Achille Julienne, Clémence Blachon + 6 more
DNA data storage is an emerging technology that has the potential to replace bulky, fragile and energy-intensive current digital data storage media. Here, we report a storage strategy called DNA Drive, that organizes data on long double stranded replicative DNA molecules. The DNA Drive has unlimited storage capacity…
Xiaoluo Huang, Junting Cui, Wei Qiang, Jianwen Ye + 4 more
'Xinying Xie' 'Yuanzhen Li' 'Junbiao Dai'] Title: Abstract Deoxyribonucleic acid (DNA) has been suggested as a very promising medium for data storage in recent years. Although numerous studies have advocated for DNA data storage, its practical application remains obscure and there is a lack of a user-oriented platform.…
Xiaoluo Huang, Yu Wang, Jiaxin Xu, Ziang Nie + 5 more
DNA data storage offers a viable strategy to address the impending data explosion. Early attempts to harness DNA as a storage medium have encountered scalability limitations, largely due to the complexity of codec algorithms, the generation of biochemically harmful sequences and lack of a robust architecture. We…
Pavani Yashodha De Silva, Gamage Upeksha Ganegoda
With the exponential growth in the capacity of information generated and the emerging need for data to be stored for prolonged period of time, there emerges a need for a storage medium with high capacity, high storage density, and possibility to withstand extreme environmental conditions. DNA emerges as the prospective…
Tomasz Buko, Nella Tuczko, Takao Ishikawa, Marco Mesiti
The demand for data storage is growing at an unprecedented rate, and current methods are not sufficient to accommodate such rapid growth due to their cost, space requirements, and energy consumption. Therefore, there is a need for a new, long-lasting data storage medium with high capacity, high data density, and high…
Elena Bencurova, Aman Akash, Renwick C.J. Dobson, Thomas Dandekar
Natural DNA storage allows cellular differentiation, evolution, the growth of our children and controls all our ecosystems. Here, we discuss the fundamental aspects of DNA storage and recent advances in this field, with special emphasis on natural processes and solutions that can be exploited. We point out new ways of…
Peter Michael Schwarz, Bernd Freisleben
Fountain codes, originally developed for reliable multicasting in communication networks, are effectively applied in various data transmission and storage systems. Their recent use in DNA data storage systems has unique challenges, since the DNA storage channel deviates from the traditional Gaussian white noise erasure…
Likun Jiang, Ziyun Zou, Xinru Ruan, Xinyi Zhang + 3 more
DNA molecules, as natural information carriers, have several benefits over conventional digital storage mediums, including high information density and long-term durability. It is expected to be a promising candidate for information storage. However, despite significant research in this field, the pace of development…
Kaleb Z. Abram, Zulema Udaondo
Schematic overview of DNA data storage.
Jiun-You Liu
DNA digital data storage is an emerging technology with the potential to keep up with increasing demands in space, energy, and materials used for information storage. To make DNA storage systems more practical and cost-effective, it is crucial to determine how the physical and chemical properties of DNA affect its…
Yifei Zhang, Lijia Jia, Xiaoxia Wang, Yue Shi + 10 more
The development of traditional silicon-based microelectronic storage media has increasingly lagged behind the rapidly growing demands of contemporary data storage. DNA storage, with its ultra-high information density and long-term preservation advantages, has rapidly become a research hotspot for next-generation…
Linda C. Meiser, Bichlien H. Nguyen, Yuan-Jyue Chen, Jeff Nivala + 3 more
'Karin Strauss' 'Luis Ceze' 'Robert N. Grass'] Synthetic DNA is a growing alternative to electronic-based technologies in fields such as data storage, product tagging, or signal processing. Its value lies in its characteristic attributes, namely Watson-Crick base pairing, array synthesis, sequencing, toehold…
Gemma Mendonsa, Sriram Chari, Mengdi Bao, Brett Herdendorf + 1 more
Oligonucleotides or gene fragments can be ligated in a specified order to create longer DNA assemblies. We present a method where DNA symbols, or oligos designed to encode information for data storage, are joined to linker sequences at either end. These linkers dictate the assembly order of the symbols; the order of…
Rushant Sabnis, Han Zhang, Bingzhe Li, Arum Han + 2 more
DNA-based data storage offers unprecedented storage density and durability compared to traditional media, but it faces challenges in long access latency and limited encoding efficiency. Current DNA storage methods achieve only 8% of the theoretical maximum storage density (TMSD) due to biological constraints and error…
Mst. Fahmida Sultana Naznin
DNA storage is a nonvolatile memory technology for storing data as synthetic DNA strings which offers unprecedented storage density and durability. Yet, the application of DNA as a practical digital information storage medium remains an enigma, since this is extremely expensive and it takes a substantial amount of time…
S. M. Hossein Tabatabaei Yazdi, Han Mao Kiah, Eva Ruiz Garcia, Jian Ma + 2 more
'Jian Ma' 'Huimin Zhao' 'Olgica Milenković'] Abstract—We provide an overview of current approaches to DNA-based storage system design and accompanying synthesis, sequencing and editing methods. We also introduce and analyze a suite of new constrained coding schemes for both archival and random access DNA storage…
Yixun Wei, Bingzhe Li, David Hung-Chang Du
—Deoxyribonucleic Acid (DNA), with its high density and long durability, is a promising storage medium for long-term archival storage and has attracted much attention. Several studies have verified the feasibility of using DNA for archival storage with a small amount of data. However, the achievable storage capacity of…
Min Li, Jiashu Wu, Junbiao Dai, Qingshan Jiang + 3 more
'Xiaoluo Huang' 'Yang Wang'] Current research on DNA storage usually focuses on the improvement of storage density by developing efective encoding and decoding schemes while lacking the consideration on the uncertainty in ultra-long-term data storage and retention. Consequently, the current DNA storage systems are…
Shalin Shah, Dixita Limbachiya, Manish K. Gupta
—The term Big Data is usually used to describe huge amount of data that is generated by humans from digital media such as cameras, internet, phones, sensors etc. By building advanced analytics on the top of big data, one can predict many things about the user such as behavior, interest etc. However before one can use…
Eugenio Marinelli, Yiqing Yan, Virginie Magnone, Pascal Barbry + 1 more
'Raja Appuswamy'] Abstract—The surge in demand for cost-effective, durable long-term archival media, coupled with density limitations of contemporary magnetic media, has resulted in synthetic DNA emerging as a promising new alternative. Despite its benefits, storing data on DNA poses several challenges as the…
Melpomeni Dimopoulou, Marc Antonini, Pascal Barbry, Raja Appuswamy
—Living in the age of the digital media explosion, the amount of data that is being stored increases dramatically. However, even if existing storage systems suggest efficiency in capacity, they are lacking in durability. Hard disks, flash, tape or even optical storage have limited lifespan in the range of 5 to 20…
HANIYEH ABDOLLAHZADEH, Tonya Peeples, Mohammad Shahcheraghi
DNA-based nanomaterials have shown great potential in numerous applications, thanks to their unique properties including DNA's various molecular interactions, programmability, and versatility with biological modules. Meanwhile, the DNA origami platforms have shown promise in the creation of drug carriers. This…
Yixun Wei, Bingzhe Li, David Hung-Chang Du
DNA storage is a promising archival data storage solution to today's big data problem. A DNA storage system encodes and stores digital data with synthetic DNA sequences and decodes DNA sequences back to digital data via sequencing. For efficient target data retrieving, existing Polymerase Chain Reaction (PCR) based DNA…
Luping Xiang, Qiang Liu, Sirong Chen, Kang Yan + 2 more
'Kun Yang'] Abstract—Exponential increase of data has motivated advances of data storage technologies. As a promising storage media, DeoxyriboNucleic Acid (DNA) storage provides a much higher data density and superior durability, compared with state-of-theart media. In this paper, we provide a tutorial on DNA storage…
Authors not listed
Encoding information in molecular arrangements on DNA origami nanostructures (DONs) provides the basis for novel concepts in molecular data storage and computing. To preserve their integrity over long timescales, the information-carrying DONs are often stored in a frozen state. Here, we investigate the effect of…
Authors not listed
Assembly of DNA origami nanostructures inside giant unilamellar vesicles (GUVs) is demonstrated by supplying approximately 200 unique staple strands from the external environment. Optimization of the lipid composition (DOPC : POPG : Cholesterol = 3:1:6) enables GUVs to withstand annealing for over 12 hours. Scaffold…
Authors not listed
Large-scale de novo nucleic acid synthesis is a powerful tool enabling researchers to better understand and engineer biological systems. Fields ranging from genomics to nucleic acid therapeutics to synthetic biology make use of high-throughput experimental approaches requiring access to large pools or libraries of DNA…
Jürgen Behr, Timm Michel, Maya Giridhar, Santra Santhosh + 11 more
Large- to ultra-large-scale synthesis of nucleic acids is becoming an increasingly important tool for understanding and manipulating biological systems, as well as for developing new technologies based on engineered biological materials, including DNA-based nanofabrication, aptamers and writing digital data at the…
Tanay Debnath, G. Andres Cisneros
Incorporation of artificial 3rd base pairs (Unnatural base pairs, UBPs) has emerged as a fundamental technique in pursuit of expanding the genetic alphabet. 2,6-dimethyl-2H-isoquiniline-1-thione: D5SIC (DS) and 2-methoxy-3-methylnaphthalene: DNAM (DN), a potential unnatural base pair (UBP) developed by Romesberg and…
Alex Lee, Joshua Rackers, William Bricker
One of the fundamental limitations of accurately modeling biomolecules like DNA is the inability to perform quantum chemistry calculations on large molecular structures. We present a machine learning model based on an equivariant Euclidean Neural Network framework to obtain quantum-accurate electron densities for…