25 papers · ranked by Valyu relevance
Pavani Yashodha De Silva, Gamage Upeksha Ganegoda
With the exponential growth in the capacity of information generated and the emerging need for data to be stored for prolonged period of time, there emerges a need for a storage medium with high capacity, high storage density, and possibility to withstand extreme environmental conditions. DNA emerges as the prospective…
Jangwon Kim, Jin H. Bae, Michael Baym, David Yu Zhang
The potential of DNA as an information storage medium is rapidly growing due to advances in DNA synthesis and sequencing. However, the chemical stability of DNA challenges the complete erasure of information encoded in DNA sequences. Here, we encode information in a DNA information solution, a mixture of true message-…
Azat Akhmetov, Andrew D. Ellington, Edward M. Marcotte
Encoding arbitrary digital information in DNA has attracted attention as a potential avenue for large scale and long term data storage. However, in order to enable DNA data storage technologies there needs to be improvements in data storage fidelity (tolerance to mutation), the facility of writing and reading the data…
Dixita Limbachiya, Manish K. Gupta
Digital data explosion drives a demand for robust and reliable data storage medium. Development of better digital storage device to accumulate Zetta bytes (1 ZB = 1021 bytes ) of data that will be generated in near future is a big challenge. Looking at limitations of present day digital storage devices, it will soon be…
Hoang Hiep Nguyen, Jeho Park, Seon Joo Park, Chang-Soo Lee + 4 more
'Seungwoo Hwang' 'Yong-Beom Shin' 'Tai Hwan Ha' 'Moonil Kim'] Validation of long-term DNA stability and integrity are essential for the use of DNA in data storage applications. Because of this, we evaluated the plasmid-based DNA data storage in a manner that preserves DNA stability and integrity. A document consisting…
Xu Yang, Langwen Lai, Xiaoli Qiang, Ming Deng + 3 more
DNA, as the storage medium in organisms, can address the shortcomings of existing electromagnetic storage media, such as low information density, high maintenance power consumption, and short storage time. Current research on DNA storage mainly focuses on designing corresponding encoders to convert binary data into DNA…
Penghao Wang, Ziniu Mu, Lijun Sun, Shuqing Si + 1 more
DNA is a natural storage medium with the advantages of high storage density and long service life compared with traditional media. DNA storage can meet the current storage requirements for massive data. Owing to the limitations of the DNA storage technology, the data need to be converted into short DNA sequences for…
Likun Jiang, Ziyun Zou, Xinru Ruan, Xinyi Zhang + 3 more
DNA molecules, as natural information carriers, have several benefits over conventional digital storage mediums, including high information density and long-term durability. It is expected to be a promising candidate for information storage. However, despite significant research in this field, the pace of development…
J. Davis, A. Bisson-Filho, D. Kadyrov, T. M. De Kort + 4 more
Shortage of raw materials needed to manufacture components for silicon-based digital memory storage has led to a search for alternatives, including systems for storing texts, images, movies and other forms of information in DNA. Use of DNA as a medium for storage of 3-D information has also been investigated. However…
Zhi Ping, Shihong Chen, Xiaoluo Huang, Sha Joe Zhu + 10 more
DNA has been reported as a promising medium of data storage for its remarkable durability and space-efficient storage capacity. Here, we propose a robust DNA-based data storage method based on a new codec algorithm, namely ‘Yin-Yang’. Using this strategy, we successfully stored different formats of files in one…
Thomas Heinis, Roman Sokolovskii, Jamie J. Alnasir
Key to DNA storage is encoding the information to a sequence of nucleotides before it can be synthesised for storage. Definition of such an encoding or mapping must adhere to multiple design restrictions. First, not all possible sequences of nucleotides can be synthesised. Homopolymers, e.g., sequences of the same…
David Haughton, Félix Balado
Background In recent times, the application of deoxyribonucleic acid (DNA) has diversified with the emergence of fields such as DNA computing and DNA data embedding. DNA data embedding, also known as DNA watermarking or DNA steganography, aims to develop robust algorithms for encoding non-genetic information in DNA.…
Bingzhe Li, Li Ou, David H. C. Du
With the rapid increase of available digital data, we are searching for a storage media with high density and capability of long-term preservation. Deoxyribonucleic Acid (DNA) storage is identified as such a promising candidate, especially for archival storage systems. However, the encoding density (i.e., how many…
Lu Yunfei, Zhang Xuncai
In this paper, we propose a DNA storage encoding scheme based on a 64-element coding table combined with forward error correction. The method encodes the data into DNA sequences by LZW compression of the original text, adding error correction codes and scrambling codes. In the encoding process, the effects of GC…
Paridhi Latawa, Nuh Aydın
| 1 | Abstract | | 2 | | --- | --- | --- | --- | | 2 | | Introduction | 2 | | 3 | | Convolutional Codes | 3 | | | 3.1 | Encoding of Binary Convolutional Codes | 3 | | | 3.2 | Decoding Convolutional Codes | 11 | | | 3.3 | Truncated Viterbi Decoding | 13 | | 4 | | DNA Codes | 17 | | | 4.1 | Constraints for the…
Mandrita Mondal, Kumar S. Ray
In modern age, the increasing complexity of computation and communication technology is leading us towards the necessity of new paradigm. As a result, unconventional approach like DNA coding theory is gaining considerable attention. The storage capacity, information processing and transmission properties of DNA…
Dixita Limbachiya, Bansari Rao, Manish K. Gupta
The idea of computing with DNA was given by Tom Head in 1987, however in 1994 in a seminal paper, the actual successful experiment for DNA computing was performed by Adleman. The heart of the DNA computing is the DNA hybridization, however, it is also the source of errors. Thus the success of the DNA computing depends…
Nathaniel Roquet, Swapnil P Bhatia, Sarah A Flickinger, Sean Mihm + 3 more
Persistent data storage is the basis of all modern information systems. The long-term value and volume of data are growing at an accelerating rate and pushing extant storage systems to their limits. DNA offers exciting potential as a storage medium, but no practical scheme has been proposed to date that can scale…
HANIYEH ABDOLLAHZADEH, Tonya Peeples, Mohammad Shahcheraghi
DNA-based nanomaterials have shown great potential in numerous applications, thanks to their unique properties including DNA's various molecular interactions, programmability, and versatility with biological modules. Meanwhile, the DNA origami platforms have shown promise in the creation of drug carriers. This…
Authors not listed
Assembly of DNA origami nanostructures inside giant unilamellar vesicles (GUVs) is demonstrated by supplying approximately 200 unique staple strands from the external environment. Optimization of the lipid composition (DOPC : POPG : Cholesterol = 3:1:6) enables GUVs to withstand annealing for over 12 hours. Scaffold…
Authors not listed
Encoding information in molecular arrangements on DNA origami nanostructures (DONs) provides the basis for novel concepts in molecular data storage and computing. To preserve their integrity over long timescales, the information-carrying DONs are often stored in a frozen state. Here, we investigate the effect of…
Cindy Ng, Anirban Samanta, Ole Aalund Mandrup, Emily Tsang + 3 more
The folding of double-stranded DNA around histones is a central mechanism in eukaryotic cells for compacting the genetic information into chromosomes. Very few artificial methods are available for controlling the shape of dsDNA at any level, whereas several artificial methods have been developed to efficiently organize…
Miloje Rakočević
In some previous works (2018a,b; 2019, 2021a,b, 2022) we presented a new type of mirror symmetry, expressed in the set of protein amino acids; such a symmetry, that it simultaneously represents the semiotic essence of the genetic code. In this paper we provide new evidences that the genetic code represents the unity of…
Tanay Debnath, G. Andres Cisneros
Incorporation of artificial 3rd base pairs (Unnatural base pairs, UBPs) has emerged as a fundamental technique in pursuit of expanding the genetic alphabet. 2,6-dimethyl-2H-isoquiniline-1-thione: D5SIC (DS) and 2-methoxy-3-methylnaphthalene: DNAM (DN), a potential unnatural base pair (UBP) developed by Romesberg and…
Sarah Westarp, Felix Kaspar, Peter Neubauer, Anke Kurreck
Nucleoside phosphorylases have progressed from an enzymatic curiosity to a viable synthetic tool. However, despite the recent advances in nucleoside phosphorylase-catalyzed nucleoside synthesis, the widespread application of these enzymes in industrial processes is still lacking. We attribute this gap to three key…