30 papers · ranked by Valyu relevance
Elena Bencurova, Aman Akash, Renwick C.J. Dobson, Thomas Dandekar
Natural DNA storage allows cellular differentiation, evolution, the growth of our children and controls all our ecosystems. Here, we discuss the fundamental aspects of DNA storage and recent advances in this field, with special emphasis on natural processes and solutions that can be exploited. We point out new ways of…
Alexandre Maes, Jeanne Le Peillet, Achille Julienne, Clémence Blachon + 6 more
DNA data storage is an emerging technology that has the potential to replace bulky, fragile and energy-intensive current digital data storage media. Here, we report a storage strategy called DNA Drive, that organizes data on long double stranded replicative DNA molecules. The DNA Drive has unlimited storage capacity…
Tomasz Buko, Nella Tuczko, Takao Ishikawa, Marco Mesiti
The demand for data storage is growing at an unprecedented rate, and current methods are not sufficient to accommodate such rapid growth due to their cost, space requirements, and energy consumption. Therefore, there is a need for a new, long-lasting data storage medium with high capacity, high data density, and high…
Xiaoluo Huang, Junting Cui, Wei Qiang, Jianwen Ye + 4 more
'Xinying Xie' 'Yuanzhen Li' 'Junbiao Dai'] Title: Abstract Deoxyribonucleic acid (DNA) has been suggested as a very promising medium for data storage in recent years. Although numerous studies have advocated for DNA data storage, its practical application remains obscure and there is a lack of a user-oriented platform.…
Xiaoluo Huang, Yu Wang, Jiaxin Xu, Ziang Nie + 5 more
DNA data storage offers a viable strategy to address the impending data explosion. Early attempts to harness DNA as a storage medium have encountered scalability limitations, largely due to the complexity of codec algorithms, the generation of biochemically harmful sequences and lack of a robust architecture. We…
Yifei Zhang, Lijia Jia, Xiaoxia Wang, Yue Shi + 10 more
The development of traditional silicon-based microelectronic storage media has increasingly lagged behind the rapidly growing demands of contemporary data storage. DNA storage, with its ultra-high information density and long-term preservation advantages, has rapidly become a research hotspot for next-generation…
Kevin N. Lin, Albert J. Keung, James M. Tuck
Technological leaps are often driven by key innovations that transform the underlying architectures of systems. Current DNA storage systems largely rely on polymerase chain reaction, which broadly informs how information is encoded, databases are organized, and files are accessed. Here we show that a hybrid ‘toehold’…
Jiun-You Liu
DNA digital data storage is an emerging technology with the potential to keep up with increasing demands in space, energy, and materials used for information storage. To make DNA storage systems more practical and cost-effective, it is crucial to determine how the physical and chemical properties of DNA affect its…
Pavani Yashodha De Silva, Gamage Upeksha Ganegoda
With the exponential growth in the capacity of information generated and the emerging need for data to be stored for prolonged period of time, there emerges a need for a storage medium with high capacity, high storage density, and possibility to withstand extreme environmental conditions. DNA emerges as the prospective…
Yixun Wei, Bingzhe Li, David Hung-Chang Du
—Deoxyribonucleic Acid (DNA), with its high density and long durability, is a promising storage medium for long-term archival storage and has attracted much attention. Several studies have verified the feasibility of using DNA for archival storage with a small amount of data. However, the achievable storage capacity of…
Arnav Solanki, Zak Griffin, Purab Ranjan Sutradhar, Karisha Pradhan + 4 more
'Caiden Merritt' 'Amlan Ganguly' 'Marc Riedel' 'Suhaib Ahmed'] DNA has been discussed as a potential medium for data storage. Potentially it could be denser, could consume less energy, and could be more durable than conventional storage media such as hard drives, solid-state storage, and optical media. However…
Yeongjae Choi, Hyung Jong Bae, Amos C. Lee, Hansol Choi + 9 more
DNA-based data storage has attracted attention because of its higher physical density of the data and longer retention time than those of conventional digital data storage^1–7^. However, previous DNA-based data storage lacked index features and the data quality of storage after a single access is not preserved…
Xiaoyuan Xu, Wen Wang, Zhi Ping
DNA-based data storage has emerged as a groundbreaking solution to the growing demand for efficient, high-density, and long-term data storage. It is attracting many researchers’ attention, who are implementing functions such as random access, searching, and data operations apart from the existing capabilities…
Gemma Mendonsa, Sriram Chari, Mengdi Bao, Brett Herdendorf + 1 more
Oligonucleotides or gene fragments can be ligated in a specified order to create longer DNA assemblies. We present a method where DNA symbols, or oligos designed to encode information for data storage, are joined to linker sequences at either end. These linkers dictate the assembly order of the symbols; the order of…
Linda C. Meiser, Bichlien H. Nguyen, Yuan-Jyue Chen, Jeff Nivala + 3 more
'Karin Strauss' 'Luis Ceze' 'Robert N. Grass'] Synthetic DNA is a growing alternative to electronic-based technologies in fields such as data storage, product tagging, or signal processing. Its value lies in its characteristic attributes, namely Watson-Crick base pairing, array synthesis, sequencing, toehold…
Dvir Ben Shabat, Adar Hadad, Avital Boruchovsky, Eitan Yaakobi + 1 more
systems Authors: Dvir Ben Shabat, Adar Hadad, Avital Boruchovsky, Eitan Yaakobi, Can Alkan DNA storage is an emerging technology that promises to revolutionize the way we store and preserve digital data (, , ). By encoding data as synthetic DNA, it becomes possible to store vast amounts of information in a very compact…
Rushant Sabnis, Han Zhang, Bingzhe Li, Arum Han + 2 more
DNA-based data storage offers unprecedented storage density and durability compared to traditional media, but it faces challenges in long access latency and limited encoding efficiency. Current DNA storage methods achieve only 8% of the theoretical maximum storage density (TMSD) due to biological constraints and error…
Bingzhe Li, Li Ou, David H. C. Du
Deoxyribonucleic Acid (DNA) as a storage medium with high density and long-term preservation properties can satisfy the requirement of archival storage for rapidly increased digital volume. The read and write processes of DNA storage are error-prone. Images widely used in social media have the properties of fault…
G. Nallappa Bhavithran, R. Selvakumar
The biggest challenge when using DNA as a storage medium is maintaining its stability. The relative occurrence of Guanine (G) and Cytosine (C) is essential for the longevity of DNA. In addition to that, reverse complementary base pairs should not be present in the code. These challenges are overcome by a proper choice…
Shalin Shah, Dixita Limbachiya, Manish K. Gupta
—The term Big Data is usually used to describe huge amount of data that is generated by humans from digital media such as cameras, internet, phones, sensors etc. By building advanced analytics on the top of big data, one can predict many things about the user such as behavior, interest etc. However before one can use…
Yixun Wei, Bingzhe Li, David Hung-Chang Du
DNA storage is a promising archival data storage solution to today's big data problem. A DNA storage system encodes and stores digital data with synthetic DNA sequences and decodes DNA sequences back to digital data via sequencing. For efficient target data retrieving, existing Polymerase Chain Reaction (PCR) based DNA…
Melpomeni Dimopoulou, Marc Antonini, Pascal Barbry, Raja Appuswamy
—Living in the age of the digital media explosion, the amount of data that is being stored increases dramatically. However, even if existing storage systems suggest efficiency in capacity, they are lacking in durability. Hard disks, flash, tape or even optical storage have limited lifespan in the range of 5 to 20…
Hadas Abraham, Barak Gahtan, Adir Kobovich, Orian Leitersdorf + 2 more
'Alex Bronstein' 'Eitan Yaakobi'] The emerging field of DNA storage employs strands of DNA bases (A/T/C/G) as a storage medium for digital information to enable massive density and durability. The DNA storage pipeline includes: (1) encoding the raw data into sequences of DNA bases; (2) synthesizing the sequences as DNA…
HANIYEH ABDOLLAHZADEH, Tonya Peeples, Mohammad Shahcheraghi
DNA-based nanomaterials have shown great potential in numerous applications, thanks to their unique properties including DNA's various molecular interactions, programmability, and versatility with biological modules. Meanwhile, the DNA origami platforms have shown promise in the creation of drug carriers. This…
Authors not listed
Encoding information in molecular arrangements on DNA origami nanostructures (DONs) provides the basis for novel concepts in molecular data storage and computing. To preserve their integrity over long timescales, the information-carrying DONs are often stored in a frozen state. Here, we investigate the effect of…
Authors not listed
Assembly of DNA origami nanostructures inside giant unilamellar vesicles (GUVs) is demonstrated by supplying approximately 200 unique staple strands from the external environment. Optimization of the lipid composition (DOPC : POPG : Cholesterol = 3:1:6) enables GUVs to withstand annealing for over 12 hours. Scaffold…
Authors not listed
Large-scale de novo nucleic acid synthesis is a powerful tool enabling researchers to better understand and engineer biological systems. Fields ranging from genomics to nucleic acid therapeutics to synthetic biology make use of high-throughput experimental approaches requiring access to large pools or libraries of DNA…
Jürgen Behr, Timm Michel, Maya Giridhar, Santra Santhosh + 11 more
Large- to ultra-large-scale synthesis of nucleic acids is becoming an increasingly important tool for understanding and manipulating biological systems, as well as for developing new technologies based on engineered biological materials, including DNA-based nanofabrication, aptamers and writing digital data at the…
Ryan A. Brady, Nicholas J. Brooks, Vito Foderà, Pietro Cicuta + 1 more
The reliable preparation of functional, ordered, nanostructured frameworks would be a game changer for many emerging technologies, from energy storage to nanomedicine. Underpinned by the excellent molecular recognition of nucleic acids, along with their facile synthesis and breadth of available functionalizations, DNA…
Ehigbai Oikeh, Jesse Ziebarth, Daniel Kirchhoff, Yongmei Wang + 1 more
In nature, DNA exists primarily in a highly compacted form. The compaction of DNA in vivo is mediated by cationic proteins; histone in somatic nuclei and protamines in sperm chromatin. The extreme, near-crystalline packaging of DNA by protamines in spermatozoa is thought essential for both efficient genetic delivery as…