13 papers · ranked by Valyu relevance
John-Sebastian Mueller, Fabio Cesar Tescarollo, Hai Sun
Epilepsy can be interpreted as altered brain rhythms from overexcitation or insufficient inhibition. Chemogenetic tools have revolutionized neuroscience research because they allow “on demand” excitation or inhibition of neurons with high cellular specificity. Designer Receptors Exclusively Activated by Designer Drugs…
Paul D. Whissell, Sarasa Tohyama, Loren J. Martin
A central goal in understanding brain function is to link specific cell populations to behavioral outputs. In recent years, the selective targeting of specific neural circuits has been made possible with the development of new experimental approaches, including chemogenetics. This technique allows for the control of…
Qi Zhang, Ruiqi Wang, Liang Zhang, Mengqi Li + 12 more
'Xiaoyang Lu' 'Yixuan Tian' 'Yunping Lin' 'Taian Liu' 'Yefei Chen' 'Yuantao Li' 'Jun Cao' 'Qiang Wu' 'Jinhui Wang' 'Zhonghua Lu' 'Zexuan Hong'] Designer receptors exclusively activated by designer drugs (DREADDs) play important roles in neuroscience research and show great promise for future clinical interventions in…
Todd B. Nentwig, J. Daniel Obray, Dylan T. Vaughan, L. Judson Chandler
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) have become a premier neuroscience research tool in the past decade for their utility in providing reversible manipulations of cellular activity following experimenter-controlled delivery of a DREADD-specific ligand. However, the commonly used DREADD…
Raphaël Goutaudier, Véronique Coizet, Carole Carcenac, Sebastien Carnicella
'Sebastien Carnicella'] Title: Visual Abstract
Raphaël Goutaudier, Véronique Coizet, Carole Carcenac, Sebastien Carnicella
Although Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) represent a technical revolution in integrative neuroscience, the first ligands used were not as selective as expected. Compound 21 (C21) was recently proposed as an alternative, but in vivo characterization of its properties is not…
Yuji Nagai, Naohisa Miyakawa, Hiroyuki Takuwa, Yukiko Hori + 26 more
The chemogenetic technology, Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), affords reversible and remote control of cellular signaling, neuronal activity and behavior. Although the combination of muscarinic-based DREADDs with clozapine-N-oxide (CNO) has been widely used, the sluggish kinetics…
Raphaël Goutaudier, Véronique Coizet, Carole Carcenac, Sebastien Carnicella + 1 more
'Sebastien Carnicella' 'Gilberto Fisone'] Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) represent a technical revolution in integrative neuroscience. However, the first used ligands exhibited dose-dependent selectivity for their molecular target, leading to potential unspecific effects. Compound…
Kate A Lawson, Christina M Ruiz, Stephen V Mahler
Designer receptors exclusively activated by designer drugs (DREADDs) are a tool for “remote control” of defined neuronal populations during behavior. These receptors are inert unless bound by an experimenter-administered designer drug, most commonly clozapine-n-oxide (CNO). However, questions have emerged about the…
Ethan S. Benevides, Prajwal P. Thakre, Sabhya Rana, Michael D. Sunshine + 3 more
Impaired respiratory motor output contributes to morbidity and mortality in many neurodegenerative diseases and neurologic injuries. We investigated if expressing designer receptors exclusively activated by designer drugs (DREADDs) in the mid-cervical spinal cord could effectively stimulate phrenic motor output to…
Evgenia Kartsaki, Gerrit Hilgen, Evelyne Sernagor, Bruno Cessac
We consider a model of basic inner retinal connectivity where bipolar and amacrine cells interconnect, and both cell types project onto ganglion cells, modulating their response output to the brain visual areas. We derive an analytical formula for the spatio-temporal response of retinal ganglion cells to stimuli taking…
Eric Garr, Andrew R. Delamater
Animals engage in intricate action sequences that are constructed during instrumental learning. There is broad consensus that the basal ganglia play a crucial role in the formation and fluid performance of action sequences. To investigate the role of the basal ganglia direct and indirect pathways in action sequencing…
Bridget R. Alber, Aman Gill, Jhansi Dyavanpalli, David Mendelowitz + 1 more
Background Current therapeutic strategies for acute myocardial infarction rely on reperfusion and pharmacological management, which are typically administered hours after an event. Activation of the cardiac cholinergic efferents superior to the heart soon after a coronary occlusion has shown promise as a potential…