20 papers · ranked by Valyu relevance
Christopher R. Merritt, Giang T. Ong, Sarah Church, Kristi Barker + 15 more
We have developed Digital Spatial Profiling (DSP), a non-destructive method for high-plex spatial profiling of proteins and RNA, using oligonucleotide detection technologies with unlimited multiplexing capability. The key breakthroughs underlying DSP are threefold: (1) multiplexed readout of proteins/RNA using…
Sanjna Nilesh Nerurkar, Denise Goh, Chun Chau Lawrence Cheung, Pei Qi Yvonne Nga + 2 more
'Pei Qi Yvonne Nga' 'Jeffrey Chun Tatt Lim' 'Joe Poh Sheng Yeong'] Simple Summary In recent years, immunotherapy has emerged as a pillar in the fight against cancer. However, the heterogeneity within the tumor microenvironment poses challenges to the efficacy of immunotherapy treatment strategies and may contribute to…
Helga Bergholtz, Jodi M. Carter, Alessandra Cesano, Maggie Chon U Cheang + 30 more
'Maggie Chon U Cheang' 'Sarah E. Church' 'Prajan Divakar' 'Christopher A. Fuhrman' 'Shom Goel' 'Jingjing Gong' 'Jennifer L. Guerriero' 'Margaret L. Hoang' 'E. Shelley Hwang' 'Hellen Kuasne' 'Jinho Lee' 'Yan Liang' 'Elizabeth A. Mittendorf' 'Jessica Perez' 'Aleix Prat' 'Lajos Pusztai' 'Jason W. Reeves' 'Yasser…
Stephanie M. Zimmerman, Robin Fropf, Bridget R. Kulasekara, Maddy Griswold + 19 more
Emerging spatial profiling technology has enabled high-plex molecular profiling in biological tissues, preserving the spatial and morphological context of gene or protein expression. Here we describe expanded chemistry for the Digital Spatial Profiling platform to quantify whole transcriptomes in human and mouse…
Duncan Yi-Te Wang, Tuan Zea Tan, Ya-Ting Tai, Jieru Ye + 3 more
Intrinsic intra-tumor heterogeneity (ITH) has been linked to worse patient outcomes. The development of spatial profiling technology has enabled the deciphering of ITH with multiple analysis readouts. Advanced ovarian clear cell carcinoma (OCCC), known to harbor ITH, is chemoresistant, poor prognostic, and possesses…
Angela R. Omilian, Haiyang Sheng, Chi‐Chen Hong, Elisa V. Bandera + 3 more
'Thaer Khoury' 'Christine B. Ambrosone' 'Song Yao'] The NanoString GeoMx digital spatial profiling is a new multiplexed platform that quantifies the abundance of tumor- and immune-related proteins in a spatially resolved manner. We performed DSP for the simultaneous assessment of 52 analytes within spatially resolved…
Kenny Roberts, Alexander Aivazidis, Vitalii Kleshchevnikov, Tong Li + 5 more
Spatial genomic technologies can map gene expression in tissues, but provide limited potential for transcriptome-wide discovery approaches and application to fixed tissue samples. Here, we introduce the GeoMX Whole Transcriptome Atlas (WTA), a new technology for transcriptome-wide spatial profiling of tissues with…
Deniz Bakkalci, Georgina Al-Badri, Wei Yang, Andy Nam + 5 more
Bioengineering facets of the tumour microenvironment (TME) are essential in 3D tissue models to accurately recapitulate tumour progression. Stromal cells are key components of the TME and their incorporation into 3D biomimetic bioengineered tumour-stroma models is essential to be able to mimic the TME. By engineering…
Joshua J. Levy, Carly A. Bobak, Mustafa Nasir-Moin, Eren M. Veziroglu + 6 more
Spatially resolved characterization of the transcriptome and proteome promises to provide further clarity on cancer pathogenesis and etiology, which may inform future clinical practice through classifier development for clinical outcomes. However, batch effects may potentially obscure the ability of machine learning…
Xin Chen, Mingliang Hou, Tao Tang, Achhardeep Kaur + 1 more
—With the arrival of the big data era, mobility profiling has become a viable method of utilizing enormous amounts of mobility data to create an intelligent transportation system. Mobility profiling can extract potential patterns in urban traffic from mobility data and is critical for a variety of traffic-related…
Qiwei Li, Minzhe Zhang, Yang Xie, Guanghua Xiao
The location, timing, and abundance of gene expression (both mRNA and proteins) within a tissue define the molecular mechanisms of cell functions. Recent technology breakthroughs in spatial molecular profiling, including imaging-based technologies and sequencing-based technologies, have enabled the comprehensive…
Almar Tillekens, Nhien‐An Le‐Khac, Thanh-Thoa Pham-Thi
—Today a lot of digital evidences for crime investigation includes a geospatial component. This data comes from various sources such as smartphones, tablets, navigation systems, digital camera with global positioning system (GPS), etc. The geospatial data plays a crucial role in crime investigation such as helping to…
Rohan Iyer, Regina Rex, Kevin P. McPherson, Darshan Gandhi + 3 more
'Aryan Mahindra' 'Abhishek Singh' 'Ramesh Raskar'] Abstract: There is a growing need for spatial privacy considerations in the many geo-spatial technologies that have been created as solutions for COVID-19-related issues. Although effective geo-spatial technologies have already been rolled out, most have significantly…
Eleanor M Setton, Perry W Hystad, C Peter Keller
Background Many epidemiological studies examining the relationships between adverse health outcomes and exposure to air pollutants use ambient air pollution measurements as a proxy for personal exposure levels. When pollution levels vary at neighbourhood levels, using ambient pollution data from sparsely located fixed…
Marcin Kulawiak, Dominik Krajnik, Marta Czaplicka, Agnieszka Dawidowicz
'Agnieszka Dawidowicz'] Spatial orientation is the effectiveness with which one is able to assess the mutual location of objects relative to a point of reference or a system of coordinates. Traditionally, this ability has been evaluated through field navigation tests, which do not take into account the prevailing…
Holger Engleitner, Ashwani Jha, Marta Suarez Pinilla, Amy Nelson + 5 more
'Daniel Herron' 'Geraint Rees' 'Karl Friston' 'Martin Rossor' 'Parashkev Nachev'] Title: Summary The characteristics and determinants of health and disease are often organized in space, reflecting our spatially extended nature. Understanding the influence of such factors requires models capable of capturing spatial…
M. Laxmaiah, A. Govardhan
Metadata represents the information about data to be stored in Data Warehouses. It is a mandatory element of Data Warehouse to build an efficient Data Warehouse. Metadata helps in data integration, lineage, data quality and populating transformed data into data warehouse. Spatial data warehouses are based on spatial…
Sarah Chambliss, Carlos Pinon, Kyle Messier, Brian LaFranchi + 5 more
Disparity in air pollution exposure arises from variation at multiple spatial scales: along urbanto-rural gradients, between individual cities within a metropolitan region, within individual neighborhoods, and between city blocks. Here, we improve on existing capabilities to systematically compare urban variation at…
Nan Jia, Arthur Daignault Bouchard, Tianyang Deng, Leon Torres de Oliveira + 2 more
In this paper, we present a generalizable method for the fabrication of disposable spectrofluidic devices for solution characterization by attenuated total reflectance (ATR) Fourier transform infrared (FTIR) spectroscopy. A major design feature is the integration of an ATR element into the device rather than the…
Authors not listed
Designing efficient photoreactors remains challenging due to the complex interplay of light transport phenomena, shaped by reflection, scattering and absorption processes. Here, we introduce a workflow that integrates ray-tracing digital twins with multi-objective Bayesian optimization to autonomously design…