14 papers · ranked by Valyu relevance
Igor C. Fontana, Débora G. Souza, Diogo O. Souza, Antony Gee + 2 more
Chemistry Perspective on Excitatory Amino Acid Transporter 2 Dysfunction in Neurodegenerative Diseases Authors: ['Igor C. Fontana' 'Débora G. Souza' 'Diogo O. Souza' 'Antony Gee' 'Eduardo R. Zimmer' 'Salvatore Bongarzone'] The excitatory amino acid transporter 2 (EAAT2) plays a key role in the clearance and recycling…
Akanksha Bhatnagar, Visha Parmar, Nicholas Barbieri, Frank Bearoff + 2 more
'Felice Elefant' 'Sandhya Kortagere'] Introduction Glutamate excitotoxicity is causal in striatal neurodegeneration underlying motor dysfunction and cognitive deficits in Huntington’s disease (HD). Excitatory amino acid transporter 2 (EAAT2), the predominant glutamate transporter accounting for >90% of glutamate…
Takafumi Kato, Tsukasa Kusakizako, Chunhuan Jin, LiLi Quan + 7 more
Glutamate is a pivotal excitatory neurotransmitter in mammalian brains, but excessive glutamate causes numerous neural disorders. Almost all extracellular glutamate is retrieved by the glial transporter, Excitatory Amino Acid Transporter 2 (EAAT2), belonging to the SLC1A family. However, in some cancers, EAAT2…
Bettina M I Mertens, Daniel Kortzak, Arne Franzen, Christoph Fahlke
Excitatory amino acid transporters (EAATs) are prototypic dual function proteins that function as coupled glutamate/Na^+^/H^+^/K^+^ transporters and as anion-selective channels. Both transport functions are intimately intertwined at the structural level: secondary active glutamate transport is based on elevator-like…
Stefan Hirschberg, Anton Dvorzhak, Seyed M. A. Rasooli-Nejad, Svilen Angelov + 6 more
Deficiency of the astrocytic excitatory amino acid transporter type 2 (EAAT2) and, consequently, inefficient glutamate clearance at corticostriatal synapses may contribute to the depression of self-initiated movements in Huntington’s disease (HD). Here we report that the removal of the last 68 amino-acids in the…
Arjen J. Boender, Raffaella Tonini
Modulation of striatal circuits is necessary for behavioral flexibility and confers the ability to adapt to environmental changes. Striatal astrocytes contribute to circuit neuromodulation by controlling the activity of ambient neurotransmitters. In particular, extracellular glutamate levels are tightly controlled by…
Martin Piskacek, Marek Havelka, Martina Rezacova, Andrea Knight + 1 more
'Sumitra Deb'] The family of the Nine amino acid Transactivation Domain, 9aaTAD family, comprises currently over 40 members. The 9aaTAD domains are universally recognized by the transcriptional machinery from yeast to man. We had identified the 9aaTAD domains in the p53, Msn2, Pdr1 and B42 activators by our prediction…
Yasuaki Tokodai, Mark Matyas, Azumi Ishigamori, Erin O’Connor + 13 more
Dysregulation of the histone methyltransferase Polycomb repressive complex 2 (PRC2) results in aberrant silencing of tumor suppressors and activation of oncogenes. Targeting PRC2 with compounds holds significant potential for both basic research and therapeutic applications. Here, we leveraged extensive structural…
Tamal Raha, S. W. Grace Cheng, Michael R Green, Jim Kadonaga
The human immunodeficiency virus type I (HIV-1) transactivator protein Tat is an unusual transcriptional activator that is thought to act solely by promoting RNA polymerase II processivity. Here we study the mechanism of Tat action by analyzing transcription complex (TC) assembly in vivo using chromatin…
Martin Piskacek, Marek Havelka, Kristina Jendruchova, Andrea Knight + 1 more
The Sp1 transcription factor has been defined as glutamine-rich activator. The Nine amino acid TransActivation Domains (9aaTAD) have been identified in numerous transcription activators. Here, we identified the conserved 9aaTAD motif in the Sp1 and in all nine members of SP family with broad natural 9aaTAD variations.…
Authors not listed
Activation of rac-Me2Si(η5-Ind)2ZrMe2 (SBIZrMe2) and sheet models for MAO, (MeAlO)6(Me3Al)4 (6,4), (MeAlO)7(Me3Al)5 (7,5), and (MeAlO)26(Me3Al)9 (26,9) has been studied by DFT. These activators can reversibly form an outer-sphere ion-pair (OSIP) [SBIZrMe2AlMe2] [(MeAlO)n(Me3Al)mMe] 3 ([n,m]− = [7,4]−and [26,8]−) or a…
Ammar Tareen, Ned S. Wingreen, Ranjan Mukhopadhyay
Are "turn-on" and "turn-off" functions in protein-protein interaction networks exact opposites of each other? To answer this question, we implement a minimal model for the evolution of functional protein-interaction networks using a sequence-based mutational algorithm, and apply the model to study neutral drift in…
Martin Piskacek, Marek Havelka, Martina Rezacova, Andrea Knight + 1 more
'Roberto Mantovani'] The Gal4 protein is a well-known prototypic acidic activator that has multiple activation domains. We have previously identified a new activation domain called the nine amino acid transactivation domain (9aaTAD) in Gal4 protein. The family of the 9aaTAD activators currently comprises over 40…
Vamshi Sammeta, Brian Anderson, John Norris, Chad Torrice + 7 more
Synthetic, structural, and computational approaches were used to solve the puzzle as to how a phenolic nonsteroidal estrogen 1 with only a single H-bond to its receptor was more potent than an isomer 2 which formed an intricate network of H-bonds. Synthesis of a series of substituted phenols revealed that pKa was not a…