18 papers · ranked by Valyu relevance
Mehdi Pirooznia, Ping Gong, Xin Guan, Laura S Inouye + 3 more
'Edward J Perkins' 'Youping Deng'] Background Eisenia fetida, commonly known as red wiggler or compost worm, belongs to the Lumbricidae family of the Annelida phylum. Little is known about its genome sequence although it has been extensively used as a test organism in terrestrial ecotoxicology. In order to understand…
Hongxin Wang, Jigen Peng, Shigang Yue
Small target motion detection is critical for insects to search for and track mates or prey which always appear as small dim speckles in the visual field. A class of specific neurons, called small target motion detectors (STMDs), has been characterized by exquisite sensitivity for small target motion. Understanding and…
Jaleela S. Hashem, Wael Ismail, Yin-Ru Chiang, Adnan A. Bekhit
Steroid estrogens, including the naturally occurring hormones estrone (E1), estradiol (E2), and estriol (E3), as well as the synthetic estrogen ethinylestradiol (EE2), play essential physiological roles in the regulation of the reproductive systems and development of secondary sex characteristics in humans and animals.…
Tsun-Hsien Hsiao, Yi-Lung Chen, Menghsiao Meng, Meng-Rong Chuang + 4 more
Steroidal estrogens are often accumulated in urban estuarine sediments worldwide at microgram per gram levels. These aromatic steroids have been classified as endocrine disruptors with an EC50 at sub-nanomolar concentrations and classified as Group 1 carcinogens by the World Health Organization. Microbial degradation…
Anna Helena Mazurek, Łukasz Szeleszczuk, Thomas Simonson, Dariusz Maciej Pisklak
'Dariusz Maciej Pisklak'] In this review, applications of various molecular modelling methods in the study of estrogens and xenoestrogens are summarized. Selected biomolecules that are the most commonly chosen as molecular modelling objects in this field are presented. In most of the reviewed works, ligand docking…
Parth Malik, Tapan Kumar Mukherjee, Andrea Manni
Title: Simple Summary Estrogens are naturally occurring steroid hormones produced by the human body serving multiple physiological roles, including the development of primary and secondary sexual organs. However, the human body can also be exposed to various environmental estrogens or estrogen-like compounds, such as…
Tsun-Hsien Hsiao, Tzong-Huei Lee, Meng-Rong Chuang, Po-Hsiang Wang + 5 more
Steroidal estrogens (C_18_) are contaminants receiving increasing attention due to their endocrine-disrupting activities at sub-nanomolar concentrations. Although estrogens can be eliminated through photodegradation, microbial function is critical for removing estrogens from ecosystems devoid of sunlight exposure…
Eunjung Lee, Jianning Luo, Yu-Chen Su, Juan Pablo Lewinger + 5 more
'Fredrick R Schumacher' 'David Van Den Berg' 'Anna H Wu' 'Leslie Bernstein' 'Giske Ursin'] Introduction Mammographic density (MD) is a strong biomarker of breast cancer risk. MD increases after women start estrogen plus progestin therapy (EPT) and decreases after women quit EPT. A large interindividual variation in…
M. Biong, M. Suderman, VD. Haakensen, B. Kulle + 8 more
We have utilized a candidate gene approach in an attempt to clarify the involvement of the estradiol pathway, through the use of SNPs, in MD. Claims about associations of estradiol with MD have been conflicting with some reporting no associations and others reporting slight associations . Here we provide evidence for…
Vamshikrishna Reddy Sammeta, John D. Norris, Sandeep Artham, Chad D. Torrice + 5 more
Despite continued interest in development of nonsteroidal estrogens and antiestrogens, there are only a few chemotypes of estrogen receptor ligands. Using targeted screening in a ligand sensing assay we identified a phenolic thieno[2,3-d]pyrimidine with affinity for estrogen receptor α. An efficient three-step…
Pooja Raval, Hannah Rae, Rodrigo R. R. Duarte, Iain A. Watson + 9 more
Estrogens, specifically 17β-estradiol (estradiol), can modulate synaptic function by regulating the expression and localisation of synaptic proteins. However, the mechanisms underlying estradiol’s regulation of synaptic protein expression, and whether if they occur in a sex specific manner, is not well understood. In…
Vamshi Sammeta, Brian Anderson, John Norris, Chad Torrice + 7 more
Synthetic, structural, and computational approaches were used to solve the puzzle as to how a phenolic nonsteroidal estrogen 1 with only a single H-bond to its receptor was more potent than an isomer 2 which formed an intricate network of H-bonds. Synthesis of a series of substituted phenols revealed that pKa was not a…
Xia Xu, Timothy D Veenstra
Background Endogenous estrogens and estrogen metabolites play an important role in the pathogenesis and development of human breast, endometrial, and ovarian cancers. Increasing evidence also supports their involvement in the development of certain lung, colon and prostate cancers. Methods In this study we systemically…
Xinge Yu, Murat Yaman, Queena Y. Zhao, Sylvia M. Emly + 9 more
Venous thrombosis is a well-known complication of estrogen exposure, with nearly every woman at risk across her lifetime through contraception, pregnancy, or hormone therapy. Although estrogens alter expression of coagulation factors, the mechanisms that mediate estrogen-induced thrombosis are poorly understood…
Che-Yi Liao, Gian-Gabriel Garcia, Kamran Paynabar, Zheng Dong + 2 more
'Yao Xie' 'Mohammad S. Jalali'] Problem definition: Efforts to mitigate the U.S. opioid crisis have been complicated by everchanging trends in opioid overdose deaths (OODs) across communities and drug types. Public health surveillance efforts are challenged with variability among these factors, making prediction of…
Shunya Yagi, Stephanie E. Lieblich, Liisa A.M. Galea
Adult neurogenesis in the dentate gyrus plays an important role for pattern separation, the process of separating similar inputs and forming distinct neural representations. Estradiol modulates neurogenesis and hippocampus function, but to date no examination of estradiol’s effects on pattern separation have been…
Asma Deeb, Hussain AlSaffar, Rasha Tarif Hamza, Abdelhadi Habeb
Inducing puberty in hypogonadal patients enables achieving normal final adult height, healthy bone mass accrual and improves fertility potential. Reliable availability and access to medicines remain a challenge around the world, particularly in low income countries. We aim to study the availability/access to…
Navid Ibtehaj Nizam, Sharmin R. Ara, Md Kamrul Hasan
—Quantitative ultrasound (QUS) based parameters like the effective scatterer diameter (ESD) and mean scatterer spacing (MSS) are gaining attention recently as non-invasive biomarkers for soft tissue characterization. In this work, we propose a multiple QUS parameter based technique that employs ESD and MSS, for binary…