17 papers · ranked by Valyu relevance
Cathrin B. Canto, Floris G. Wouterlood, Menno P. Witter
The entorhinal cortex is commonly perceived as a major input and output structure of the hippocampal formation, entertaining the role of the nodal point of cortico-hippocampal circuits. Superficial layers receive convergent cortical information, which is relayed to structures in the hippocampus, and hippocampal output…
Menno P. Witter, Thanh P. Doan, Bente Jacobsen, Eirik S. Nilssen + 1 more
'Shinya Ohara'] The entorhinal cortex (EC) is the major input and output structure of the hippocampal formation, forming the nodal point in cortico-hippocampal circuits. Different division schemes including two or many more subdivisions have been proposed, but here we will argue that subdividing EC into two components…
Heidrun Schultz, Tobias Sommer, Jan Peters
Connectivity studies in animals form the basis for a representational view of medial temporal lobe (MTL) subregions. In this view, distinct subfields of the entorhinal cortex (EC) relay object-related and spatial information from the perirhinal and parahippocampal cortices (PRC, PHC) to the hippocampus (HC). Relatively…
Sergio Plaza-Alonso, Nicolás Cano-Astorga, Javier DeFelipe, Lidia Alonso-Nanclares
The entorhinal cortex (EC) plays a pivotal role in memory function and spatial navigation, connecting the hippocampus with the neocortex. The EC integrates a wide range of cortical and subcortical inputs, but its synaptic organization in the human brain is largely unknown. We used volume electron microscopy to perform…
M Domínguez-Álvaro, M Montero-Crespo, L Blazquez-Llorca, J DeFelipe + 1 more
The entorhinal cortex (EC) is a brain region that has been shown to be essential for memory functions and spatial navigation. However, detailed 3D synaptic morphology analysis and identification of postsynaptic targets at the ultrastructural level have not been performed before in the human EC. In the present study, we…
Ingrid Framås Syversen, Menno P. Witter, Asgeir Kobro-Flatmoen, Pål Erik Goa + 2 more
The medial (MEC) and lateral entorhinal cortex (LEC), widely studied in rodents, are well defined and characterized. In humans, however, the exact locations of their homologues remain uncertain. Previous functional magnetic resonance imaging (fMRI) studies have subdivided the human EC into posterior-medial (pmEC) and…
Ricardo Insausti, Marta Córcoles-Parada, Mar Maria Ubero, Adriana Rodado + 2 more
'Adriana Rodado' 'Ana Maria Insausti' 'Mónica Muñoz-López'] The Gyrus ambiens is a gross anatomical prominence in the medial temporal lobe (MTL), associated closely with Brodmann area 34 (BA34). It is formed largely by the medial intermediate subfield of the entorhinal cortex (EC) [Brodmann area 28 (BA28)]. Although…
Shogo Soma, Shinya Ohara, Satoshi Nonomura, Junichi Yoshida + 5 more
The entorhinal cortex (EC) is the main interface between the hippocampus and the neocortex. The EC plays a critical role in learning and memory. We investigated the neuronal representation of behavioral events during operant learning in the hippocampal-entorhinal circuit of head-fixed rats. Both CA1 and lateral…
Ingrid Framås Syversen, Daniel Reznik, Menno P. Witter, Asgeir Kobro-Flatmoen + 2 more
In the entorhinal cortex (EC), attempts have been made to identify the human homologue regions of the medial (MEC) and lateral (LEC) subdivision using either functional magnetic resonance imaging (fMRI) or diffusion tensor imaging (DTI). However, there are still discrepancies between entorhinal subdivisions depending…
Xenia Grande, Magdalena Sauvage, Andreas Becke, Emrah Düzel + 1 more
Cortical processing streams for item and contextual information come together in the entorhinal-hippocampal circuitry. Various evidence suggest that information-specific pathways organize the cortical – entorhinal interaction and the circuitry’s inner communication along the transversal axis. Here, we leveraged…
Jochen Kerdels, Gabriele Peters
About a decade ago grid cells were discovered in the medial entorhinal cortex of rat. Their peculiar firing patterns, which correlate with periodic locations in the environment, led to early hypothesis that grid cells may provide some form of metric for space. Subsequent research has since uncovered a wealth of new…
Akira Taniguchi, Ayako Fukawa, Hiroshi Yamakawa
In building artificial intelligence (AI) agents, referring to how brains function in real environments can accelerate development by reducing the design space. In this study, we propose a probabilistic generative model (PGM) for navigation in uncertain environments by integrating the neuroscientific knowledge of…
Hossein Haghir, Anika Kuckertz, Ling Zhao, Javad Hami + 1 more
'Nicola Palomero-Gallagher'] Neurotransmitters and their receptors are key molecules in information transfer between neurons, thus enabling inter-areal communication. Therefore, multimodal atlases integrating the brain’s cyto- and receptor architecture constitute crucial tools to understand the relationship between its…
Jiawei Zhang
In this paper, we will provide an introduction to the brain structure and function. Brain is an astonishing living organ inside our heads, weighing about 1.5kg, consisting of billions of tiny cells. The brain enables us to sense the world around us (to touch, to smell, to see and to hear, etc.), to think and to respond…
Sudhakar Mishra, Uma Shanker Tiwary
The focus of the efforts for defining and modelling emotion is broadly shifting from classical definite marker theory to statistically context situated conceptual theory. However, the role of context processing and its interaction with the affect is still not comprehensively explored and modelled. With the help of…
Taiping Zeng, Xiaoli Li, Bailu Si
—Fourier-like summation of several grid cell modules with different spatial frequencies in the medial entorhinal cortex (MEC) has long been proposed to form the contours of place firing fields. Recent experiments largely, but not completely, support this theory. Place fields are obviously expanded by inactivation of…
Bo Yu, Jiangning Wei, Minzhen Hu, Zejie Han + 3 more
'Jun Liu'] Abstract—Artificial General Intelligence (AGI), widely regarded as the fundamental goal of artificial intelligence, represents the realization of cognitive capabilities that enable the handling of general tasks with human-like proficiency. Researchers in brain-inspired AI seek inspiration from the…