16 papers · ranked by Valyu relevance
Il Bin Kim, Seon-Cheol Park, Estela Castilla Ortega
Depression is characterized by impairments in adult neurogenesis. Reduced hippocampal function, which is suggestive of neurogenesis impairments, is associated with depression-related phenotypes. As adult neurogenesis operates in an activity-dependent manner, disruption of hippocampal neurogenesis in depression may be a…
Jason O. Toy
Since their Nobel Prize winning discovery in 2005, grid cells have been studied extensively by neuroscientists. Their multi-scale periodic firing rates tiling the environment as the animal moves around has been shown as critical for path integration. Multiple experiments have shown that grid cells also fire for other…
Xenia Grande, Magdalena Sauvage, Andreas Becke, Emrah Düzel + 1 more
Cortical processing streams for item and contextual information come together in the entorhinal-hippocampal circuitry. Various evidence suggest that information-specific pathways organize the cortical – entorhinal interaction and the circuitry’s inner communication along the transversal axis. Here, we leveraged…
Shogo Soma, Shinya Ohara, Satoshi Nonomura, Junichi Yoshida + 5 more
The entorhinal cortex (EC) is the main interface between the hippocampus and the neocortex. The EC plays a critical role in learning and memory. We investigated the neuronal representation of behavioral events during operant learning in the hippocampal-entorhinal circuit of head-fixed rats. Both CA1 and lateral…
Sergio Plaza-Alonso, Nicolás Cano-Astorga, Javier DeFelipe, Lidia Alonso-Nanclares
The entorhinal cortex (EC) plays a pivotal role in memory function and spatial navigation, connecting the hippocampus with the neocortex. The EC integrates a wide range of cortical and subcortical inputs, but its synaptic organization in the human brain is largely unknown. We used volume electron microscopy to perform…
Ming‐Li Li, Shi‐Hao Wu, Bo Song, Jing Yang + 5 more
'Yun‐Chao Wang' 'Jing‐Hua Yang' 'Yuming Xu'] Title: Abstract The entorhinal cortex is of great importance in cognition and memory, its dysfunction causes a variety of neurological diseases, particularly Alzheimer's disease (AD). Yet so far, research on entorhinal cortex is still limited. Here, we provided the first…
Jean-Marie Graïc, Annamaria Grandis, Simona Sacchini, Claudio Tagliavia + 3 more
'Claudio Tagliavia' 'Giulia Salamanca' 'Bruno Cozzi' 'Cristiano Bombardi'] Introduction The entorhinal cortex has been shown to be involved in high-level cognitive functions in terrestrial mammals. It can be divided into two main areas: the lateral entorhinal area (LEA) and the medial entorhinal area (MEA).…
Ingrid Framås Syversen, Daniel Reznik, Menno P. Witter, Asgeir Kobro-Flatmoen + 2 more
In the entorhinal cortex (EC), attempts have been made to identify the human homologue regions of the medial (MEC) and lateral (LEC) subdivision using either functional magnetic resonance imaging (fMRI) or diffusion tensor imaging (DTI). However, there are still discrepancies between entorhinal subdivisions depending…
Elizabeth A.M.A. Allison, Joe W. Moore, Paul A. Dudchenko, Emma R. Wood
A fundamental property of place cells in the hippocampus is the anchoring of their firing fields to salient landmarks within the environment. However, it is unclear how such information reaches the hippocampus. In the current experiment, we tested the hypothesis that the stimulus control exerted by distal visual…
Shogo Soma, Shinya Ohara, Satoshi Nonomura, Naofumi Suematsu + 5 more
'Junichi Yoshida' 'Eva Pastalkova' 'Yutaka Sakai' 'Ken-Ichiro Tsutsui' 'Yoshikazu Isomura'] The hippocampus and entorhinal cortex are deeply involved in learning and memory. However, little is known how ongoing events are processed in the hippocampal-entorhinal circuit. By recording from head-fixed rats during…
Isabella C. Wagner, Luise P. Graichen, Boryana Todorova, Andre Lüttig + 3 more
'Andre Lüttig' 'David B. Omer' 'Matthias Stangl' 'Claus Lamm'] Navigating through crowded, dynamically changing environments requires the ability to keep track of other individuals. Grid cells in the entorhinal cortex are a central component of self-related navigation but whether they also track others’ movement is…
Jonathan J. Horsley, Yujiang Wang, Callum Simpson, Vyte Janiukstyte + 5 more
'Karoline Leiberg' 'Beth Little' 'Jane de Tisi' 'John S. Duncan' 'Peter N. Taylor'] Status epilepticus (SE) carries risks of morbidity and mortality. Experimental studies have implicated the entorhinal cortex in prolonged seizures; however, studies in large human cohorts are limited. We hypothesised that individuals…
Akira Taniguchi, Ayako Fukawa, Hiroshi Yamakawa
In building artificial intelligence (AI) agents, referring to how brains function in real environments can accelerate development by reducing the design space. In this study, we propose a probabilistic generative model (PGM) for navigation in uncertain environments by integrating the neuroscientific knowledge of…
Á. Martínez Novo, Francisco Lobon, Héctor García de Marina, Samuel Romero + 1 more
'Samuel Romero' 'Francisco Barranco'] With the fast and unstoppable evolution of robotics and artificial intelligence, effective autonomous navigation in real-world scenarios has become one of the most pressing challenges in the literature. However, demanding requirements, such as real-time operation, energy and…
Hossein Haghir, Anika Kuckertz, Ling Zhao, Javad Hami + 1 more
'Nicola Palomero-Gallagher'] Neurotransmitters and their receptors are key molecules in information transfer between neurons, thus enabling inter-areal communication. Therefore, multimodal atlases integrating the brain’s cyto- and receptor architecture constitute crucial tools to understand the relationship between its…
Paul Stoewer, Achim Schilling, Andreas Maier, Patrick Krauß
Cognitive maps are a proposed concept on how the brain efficiently organizes memories and retrieves context out of them. The entorhinal-hippocampal complex is heavily involved in episodic and relational memory processing, as well as spatial navigation and is thought to built cognitive maps via place and grid cells. To…