11 papers · ranked by Valyu relevance
Dominik Kopczynski, Wout Bittremieux, David Bouyssié, Viktoria Dorfer + 6 more
'Viktoria Dorfer' 'Marie Locard-Paulet' 'Bart Van Puyvelde' 'Veit Schwämmle' 'Alessio Soggiu' 'Sander Willems' 'Julian Uszkoreit'] The 2019 European Bioinformatics Community (EuBIC) Winter School was held from January 15th to January 18th 2019 in Zakopane, Poland. This year’s meeting was the third of its kind and…
Tomoya Sakuma, Yuki Otani, Hideyuki Shimizu
Mapping the intricate network of E3 ubiquitin ligase-substrate interactions (ESIs), essential for cellular regulation and implicated in numerous diseases including cancer, remains a central challenge limiting mechanistic understanding. Existing experimental and computational methods suffer from limitations in…
Feng Wang, Qing He, Wenhu Zhan, Ziqi Yu + 4 more
The human UBR5 (also known as EDD) is a single polypeptide chain HECT-type E3 ubiquitin ligase essential for embryonic development in mammals. Although widely expressed, UBR5 is markedly amplified and overexpressed in breast, ovarian, prostate, gastric and pancreatic cancers. Dysregulated UBR5 functions like an…
Matthew Gardner, Celeste Bowden, Shoaib Manzoor, Gyles Cozier + 14 more
Synthetic cannabinoids (SCs) are novel psychoactive substances (NPS) that are highly potent and associated with a range of severe toxicities. SC use, which is common in UK prisons and homeless communities, typically involves combustion of SC-soaked herb or paper material. Recently, e-cigarettes (or vapes) have emerged…
Fanchao Liao, Jaap Vleugel, Gustav Bösehans, Dilum Dissanayake + 4 more
'Neil Thorpe' 'MC Bell' 'Bart van Arem' 'Gonçalo Homem de Almeida Correia'] Electric mobility hubs (eHUBS) are locations where multiple shared electric modes including electric cars and e-bikes are available. To assess their potential to reduce private car use, it is important to investigate to what extent people would…
Silvano Gallus, Alessandra Lugo, Chiara Stival, Sonia Cerrai + 12 more
'Luke Clancy' 'Filippos T. Filippidis' 'Giuseppe Gorini' 'Maria José Lopez' 'Ángel López-Nicolás' 'Sabrina Molinaro' 'Anna Odone' 'Joan B. Soriano' 'Olena Tigova' 'Piet A. van den Brandt' 'Constantine I. Vardavas' 'Esteve Fernandez' ''] Background Limited data on electronic cigarette prevalence, patterns, and settings…
Gunther Eysenbach, Ron Borland, Darla Kendzor, Jennifer L Pearson + 9 more
Background Assessing the frequency and intensity of e-cigarette use presents special challenges beyond those posed by cigarette use. Accurate measurement of e-cigarette consumption, puff duration, and the stability of these measures over time will be informative for estimating the behavioral and health effects of…
U. Breunig, Roberto Baldacci, Richard F. Hartl, Thibaut Vidal
Two-echelon distribution systems are attractive from an economical standpoint and help to keep large vehicles out of densely populated city centers. Large trucks can be used to deliver goods to intermediate facilities in accessible locations, whereas smaller vehicles allow to reach the final customers. Due to their…
Anthony A. Laverty, Constantine I. Vardavas, Filippos T. Filippidis
Data were analysed from the 2014 Special Eurobarometer for Tobacco survey. We estimated self-rated importance of various factors in the choice of both tobacco and electronic cigarettes (e-cigarettes) among tobacco smokers who had ever used an e-cigarette. Among ever users of tobacco and e-cigarettes (N = 2430), taste…
Zuzana Hodáková, Irina Grishkovskaya, Hanna L. Brunner, Derek L. Bolhuis + 5 more
UBR5 is a nuclear E3 ligase that ubiquitinates a vast range of substrates for proteasomal degradation. This HECT E3 ligase has recently been identified as an important regulator of oncogenes, e.g., MYC, but little is known about its structure or mechanisms of substrate engagement and ubiquitination. Here, we present…
Judita Kinkorova, Ondrej Topolcan
The European Institute of Innovation and Technology (EIT) was based in 2008 in Budapest as a body of the European Union and its mission is “to Increase European sustainable growth and competitiveness by reinforcing the innovation capacity of the EU”. The aim is to enhance Europe’s ability to innovate, which translates…