27 papers · ranked by Valyu relevance
Aniek F. Markus, Jan A. Kors, Peter R. Rijnbeek
Artificial intelligence (AI) has huge potential to improve the health and well-being of people, but adoption in clinical practice is still limited. Lack of transparency is identified as one of the main barriers to implementation, as clinicians should be confident the AI system can be trusted. Explainable AI has the…
Pantelis Linardatos, Vasilis Papastefanopoulos, Sotiris Kotsiantis
Recent advances in artificial intelligence (AI) have led to its widespread industrial adoption, with machine learning systems demonstrating superhuman performance in a significant number of tasks. However, this surge in performance, has often been achieved through increased model complexity, turning such systems into…
Laura Arbelaez Ossa, Georg Starke, Giorgia Lorenzini, Julia E Vogt + 2 more
'David M Shaw' 'Bernice Simone Elger'] Using artificial intelligence to improve patient care is a cutting-edge methodology, but its implementation in clinical routine has been limited due to significant concerns about understanding its behavior. One major barrier is the explainability dilemma and how much explanation…
Kacper Sokol, Peter Flach
Explainable artificial intelligence and interpretable machine learning are research domains growing in importance. Yet, the underlying concepts remain somewhat elusive and lack generally agreed definitions. While recent inspiration from social sciences has refocused the work on needs and expectations of human…
Sheikh Rabiul Islam, William Eberle, Sheikh Ghafoor
Artificial Intelligence (AI) has become an integral part of domains such as security, finance, healthcare, medicine, and criminal justice. Explaining the decisions of AI systems in human terms is a key challenge—due to the high complexity of the model, as well as the potential implications on human interests, rights…
Michael Merry, Pat Riddle, Jim Warren
Background Wide-ranging concerns exist regarding the use of black-box modelling methods in sensitive contexts such as healthcare. Despite performance gains and hype, uptake of artificial intelligence (AI) is hindered by these concerns. Explainable AI is thought to help alleviate these concerns. However, existing…
Jay Hegdé, Evgeniy Bart
In everyday life, we rely on human experts to make a variety of complex decisions, such as medical diagnoses. These decisions are typically made through some form of weakly guided learning, a form of learning in which decision expertise is gained through labeled examples rather than explicit instructions. Expert…
Matteo Rizzo, Alberto Veneri, Matteo Marcuzzo, Alessandro Zangari + 4 more
Explainable Artificial Intelligence, or XAI, is a vibrant research topic in the artificial intelligence community. It is raising growing interest across methods and domains, especially those involving high-stakes decision-making, such as the biomedical sector. Much has been written about the subject, yet XAI still…
Meike Nauta, Jan Trienes, Shreyasi Pathak, Elisa Nguyen + 5 more
'Michelle Peters' 'Yasmin Schmitt' 'Jörg Schlötterer' 'Maurice van Keulen' 'Christin Seifert'] MEIKE NAUTA, University of Twente, the Netherlands and University of Duisburg-Essen, Germany JAN TRIENES, University of Duisburg-Essen, Germany SHREYASI PATHAK, University of Twente, the Netherlands and University of…
Muhammad Salar Khan, Mehdi Nayebpour, Meng-Hao Li, Hadi El-Amine + 6 more
'Naoru Koizumi' 'James L. Olds' 'Isa Ebtehaj' 'Sayed M. Bateni' 'Babak Mohammadi' 'Stanislav N. Gorb'] European law now requires AI to be explainable in the context of adverse decisions affecting the European Union (EU) citizens. At the same time, we expect increasing instances of AI failure as it operates on imperfect…
Félix Furger, Julien Aligon, Miguel Thomas, Emmanuel Doumard + 3 more
In the last decades, the utility of Machine Learning (ML) in the biomedical domain has been demonstrated repeatedly. Their inherent opacity need augmenting ML with explainability techniques. A common practice in model explainability however, is to focus solely on the explanatory values themselves without accounting for…
D. Petkovic, A. Alavi, D. Cai, J. Yang + 1 more
Machine Learning (ML) is becoming an increasingly critical technology in many areas. However, its complexity and its frequent non-transparency create significant challenges, especially in the biomedical and health areas. One of the critical components in addressing the above challenges is the explainability or…
Valérie Beaudouin, Isabelle Bloch, David Bounie, Stéphan Clémençon + 5 more
'Florence d’Alché–Buc' 'James Eagan' 'Winston Maxwell' 'Pavlo Mozharovskyi' 'Jayneel Parekh'] The recent enthusiasm for artificial intelligence (AI) is due principally to advances in deep learning. Deep learning methods are remarkably accurate, but also opaque, which limits their potential use in safety-critical…
Kotaro Okazaki, Katsumi Inoue
Due to advances in computing power and internet technology, various industrial sectors are adopting IT infrastructure and artificial intelligence (AI) technologies. Recently, data-driven predictions have attracted interest in high-stakes decision-making. Despite this, advanced AI methods are less often used for such…
Haomiao Wang, Julien Aligon, Julien May, Emmanuel Doumard + 6 more
Although the benefits of machine learning (ML) are undeniable in health-care, explainability plays a vital role in improving transparency and understanding the most decisive and persuasive variables for prediction. The challenge is to identify explanations that make sense to the biomedical expert. This work proposes…
Manu Aggarwal, NG Cogan, Vipul Periwal
Deep neural networks (DNNs) are powerful tools for data-driven predictive machine learning, but their complex architecture obscures mechanistic relations that they have learned from data. This information is critical to the scientific method of hypotheses development, experiment design, and model validation, especially…
Emanuele Albini, Antonio Rago, Pietro Baroni, Francesca Toni
The pursuit of trust in and fairness of AI systems in order to enable human-centric goals has been gathering pace of late, often supported by the use of explanations for the outputs of these systems. Several properties of explanations have been highlighted as critical for achieving trustworthy and fair AI systems, but…
Authors not listed
Traditional and non-classical machine learning models for solid-state structure prediction have predominantly relied on compositional features (derived from properties of constituent elements) to predict the existence of structure and its properties. However, the lack of structural information can be a source of…
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Explainability methods in machine learning-driven research are increasingly being used, but it remains challenging to assess their reliability without deeply investigating the specific problem at hand. In this work, we present a Python-based Workflow for Interpretability Scoring using matched molecular Pairs (WISP).…
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In our previous work, we introduced WISP (Workflow for Interpretability Scoring using matched molecular Pairs), which enables users to quantitatively assess the performance of explainability methods for machine learning models. In this work, we focus on more complex tasks, such as yield prediction, pKi values for…
Jacqueline Michelle Metsch, Philip Hempel, Miriam Cindy Maurer, Nicolai Spicher + 1 more
Despite the growing success of deep learning (DL) in multivariate time-series classification, such as 12-lead electrocardiography (ECG), widespread integration into clinical practice has yet to be achieved. The limited transparency of DL hinders clinical adoption, where understanding model decisions is crucial for…
Marco Bertolini, Linlin Zhao, Djork-Arné Clevert, Floriane Montanari
The field of explainable AI applied to molecular property prediction models has often been reduced to deriving atomic contributions. This has impaired the interpretability of such models, as chemists rather think in terms of larger, chemically meaningful structures, which often do not simply reduce to the sum of their…
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Predicting drug-induced toxicity remains a central challenge in computational toxicology, particularly for organ-specific adverse effects that arise from diverse structural, biochemical, and mechanistic origins. Existing deep learning models excel at pattern recognition but often lack mechanistic interpretability…
Charles A. Ellis, Robyn L. Miller, Vince D. Calhoun
The frequency domain of electroencephalography (EEG) data has developed as a particularly important area of EEG analysis. EEG spectra have been analyzed with explainable machine learning and deep learning methods. However, as deep learning has developed, most studies use raw EEG data, which is not well-suited for…
Daniel S. Weld, Gagan Bansal
Since Artificial Intelligence (AI) software uses techniques like deep lookahead search and stochastic optimization of huge neural networks to fit mammoth datasets, it often results in complex behavior that is difficult for people to understand. Yet organizations are deploying AI algorithms in many mission-critical…
Abhinav Sattiraju, Charles A. Ellis, Robyn L. Miller, Vince D. Calhoun
Schizophrenia (SZ) is a neuropsychiatric disorder that affects millions globally. Current diagnosis of SZ is symptom-based, which poses difficulty due to the variability of symptoms across patients. To this end, many recent studies have developed deep learning methods for automated diagnosis of SZ, especially using raw…
Authors not listed
Accurate prediction of melting points for pure molecules remains a significant challenge in predictive chemistry, with implications across various scientific fields, including materials science, drug discovery, and separations chemistry. Traditional methods, such as group contribution (GC) techniques, have shown…