19 papers · ranked by Valyu relevance
Irene Papatheodorou, Pablo Moreno, Jonathan Manning, Alfonso Muñoz-Pomer Fuentes + 21 more
'Alfonso Muñoz-Pomer Fuentes' 'Nancy George' 'Silvie Fexova' 'Nuno A Fonseca' 'Anja Füllgrabe' 'Matthew Green' 'Ni Huang' 'Laura Huerta' 'Haider Iqbal' 'Monica Jianu' 'Suhaib Mohammed' 'Lingyun Zhao' 'Andrew F Jarnuczak' 'Simon Jupp' 'John Marioni' 'Kerstin Meyer' 'Robert Petryszak' 'Cesar Augusto Prada\xa0Medina'…
Robert Petryszak, Maria Keays, Y. Amy Tang, Nuno A. Fonseca + 20 more
'Elisabet Barrera' 'Tony Burdett' 'Anja Füllgrabe' 'Alfonso Muñoz-Pomer Fuentes' 'Simon Jupp' 'Satu Koskinen' 'Oliver Mannion' 'Laura Huerta' 'Karine Megy' 'Catherine Snow' 'Eleanor Williams' 'Mitra Barzine' 'Emma Hastings' 'Hendrik Weisser' 'James Wright' 'Pankaj Jaiswal' 'Wolfgang Huber' 'Jyoti Choudhary' 'Helen E.…
Robert Petryszak, Tony Burdett, Benedetto Fiorelli, Nuno A. Fonseca + 17 more
'Mar Gonzalez-Porta' 'Emma Hastings' 'Wolfgang Huber' 'Simon Jupp' 'Maria Keays' 'Nataliya Kryvych' 'Julie McMurry' 'John C. Marioni' 'James Malone' 'Karine Megy' 'Gabriella Rustici' 'Amy Y. Tang' 'Jan Taubert' 'Eleanor Williams' 'Oliver Mannion' 'Helen E. Parkinson' 'Alvis Brazma'] Expression Atlas…
Pablo Moreno, Silvie Fexova, Nancy George, Jonathan R Manning + 30 more
'Zhichiao Miao' 'Suhaib Mohammed' 'Alfonso Muñoz-Pomer' 'Anja Fullgrabe' 'Yalan Bi' 'Natassja Bush' 'Haider Iqbal' 'Upendra Kumbham' 'Andrey Solovyev' 'Lingyun Zhao' 'Ananth Prakash' 'David García-Seisdedos' 'Deepti\xa0J Kundu' 'Shengbo Wang' 'Mathias Walzer' 'Laura Clarke' 'David Osumi-Sutherland' 'Marcela\xa0Karey…
Pedro Madrigal, Anil S Thanki, Silvie Fexova, Iris D Yu + 44 more
Expression Atlas ([https://www.ebi.ac.uk/gxa/home]()) is EMBL-EBI’s comprehensive knowledgebase for gene and protein expression across tissues, cell types, conditions, and multiple species. Since our last update, Expression Atlas has expanded substantially in both content and functionality, now comprising >4500 studies…
Carlos Castro-González, Miguel A. Luengo-Oroz, Louise Duloquin, Thierry Savy + 9 more
'Thierry Savy' 'Barbara Rizzi' 'Sophie Desnoulez' 'René Doursat' 'Yannick L. Kergosien' 'María J. Ledesma-Carbayo' 'Paul Bourgine' 'Nadine Peyriéras' 'Andrés Santos' 'Xianghong Jasmine Zhou'] A gene expression atlas is an essential resource to quantify and understand the multiscale processes of embryogenesis in time…
Zachary Hemminger, Gaby Tam, Haley De Ocampo, Aihui Wang + 7 more
Genetic variation can alter organ structure and, in turn, function. Comparative statistical analysis of organs across genetic backgrounds requires spatial, single-cell, atlas-scale data in replicates, which current technologies do not provide at scale. We introduce Atlas-scale Transcriptome Localization using Aggregate…
Pascal Grange, Partha P. Mitra
—The three-dimensional data-driven Anatomic Gene Expression Atlas of the adult mouse brain consists of numerized in situ hybridization data for thousands of genes, co-registered to the Allen Reference Atlas. We propose quantitative criteria to rank genes as markers of a brain region, based on the localization of the…
Zachary Hemminger, Gabriela Sanchez-Tam, Haley De Ocampo, Aihui Wang + 7 more
Genetic variation can alter brain structure and, consequently, function. Comparative statistical analysis of mouse brains across genetic backgrounds requires spatial, single-cell, atlas-scale data, in replicates—a challenge for current technologies. We introduce Atlas-scale Transcriptome Localization using Aggregate…
Aurina Arnatkevičiūtė, Ben D. Fulcher, Alex Fornito
The recent availability of comprehensive, brain-wide gene expression atlases such as the Allen Human Brain Atlas (AHBA) has opened new opportunities for understanding how spatial variations on the molecular scale relate to the macroscopic neuroimaging phenotypes. A rapidly growing body of literature is demonstrating…
Pascal Grange, Michael Hawrylycz, Partha Mitra
We review quantitative methods and software developed to analyze genome-scale, brain-wide spatially-mapped gene-expression data. We expose new methods based on the underlying high-dimensional geometry of voxel space and gene space, and on simulations of the distribution of co-expression networks of a given size. We…
Pascal Grange, Jason W. Bohland, Michael Hawrylycz, Partha Mitra
| 1 | Preface | | 5 | | --- | --- | --- | --- | | 2 | | The voxel-based Allen Atlas of the adult mouse brain | 7 | | | 2.1 | Presentation of the dataset | 7 | | | | 2.1.1 Co-registered in situ hybridization data | 7 | | | | 2.1.2 Data matrices and gene filters | 7 | | | 2.2 | From matrices to volumes | 9 | | | | 2.2.1…
Tyler Roberts, Yong Zhong Liang, Gerald C. Cupchik, Jonathan S. Cant + 1 more
Expression recognition relies on the ability to distinguish subtle visual differences across a range of facial expressions. Here, we examine the neural representation of dynamic expressions as reflected by electroencephalography (EEG) data in human adults. We find that a wide range of expressions (i.e., 14 emotional…
Khalid Raza
Microarray is one of the essential technologies used by the biologist to measure genome-wide expression levels of genes in a particular organism under some particular conditions or stimuli. As microarrays technologies have become more prevalent, the challenges of analyzing these data for getting better insight about…
Heidi Kleven, Thomas H. Gillespie, Lyuba Zehl, Timo Dickscheid + 3 more
Brain atlases are important reference resources for accurate anatomical description of neuroscience data. Open access, three-dimensional atlases serve as spatial frameworks for integrating experimental data and defining regions-of-interest in analytic workflows. However, naming conventions, parcellation criteria, area…
Authors not listed
The mechanisms underlying human odor recognition remain largely unclear, making it challenging to predict the scent of a novel molecule based solely on its molecular structure. Unlike taste, which is classified into a limited number of categories, odor perception is highly complex and lacks universally defined labels…
John G. Samuelsson, Jeremy D. Schmahmann, Martin Sereno, Bruce Rosen + 1 more
Scientific interest in the cerebellum has surged in the last few decades with an emerging consensus on a multifaceted functionality and intricate, but not yet fully understood, functional topography over the cerebellar cortex. To further refine this structure-function relationship and quantify its inter-subject…
Azusa Tanaka, Yasuhiro Ishitsuka, Hiroki Ohta, Norihiro Takenouchi + 7 more
'Masanori Nakagawa' 'Ki‐Ryang Koh' 'Chiho Onishi' 'Hiromitsu Tanaka' 'Akihiro Fujimoto' 'Jun‐ichirou Yasunaga' 'Masao Matsuoka'] Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy (HAM) after a long latent period in a fraction of infected individuals. These…
Riley Hickman, Malcolm Sim, Sergio Pablo-García, Ivan Woolhouse + 6 more
Self-driving laboratories (SDLs) are next-generation research and development platforms for closed-loop, autonomous experimentation that combine ideas from artificial intelligence, robotics, and high-performance computing. A critical component of SDLs is the decision-making algorithm used to prioritize experiments to…