23 papers · ranked by Valyu relevance
Marie-Christine Alessi, Nicolas Cenac, Mustapha Si-Tahar, Béatrice Riteau
'Béatrice Riteau'] The Formyl-peptide receptor-2 (FPR2) is a seven transmembrane G protein-coupled receptor, which plays an important role in sensing of bacteria and modulation of immune responses. FPR2 is also used by viruses for their own profit. Annexin A1, one of the multiple ligands of FPR2, is incorporated in the…
Cheng Xue Qin, Lucy V. Norling, Elizabeth A. Vecchio, Eoin P. Brennan + 5 more
'Eoin P. Brennan' 'Lauren T. May' 'Denise Wootten' 'Catherine Godson' 'Mauro Perretti' 'Rebecca H. Ritchie'] We discuss the fascinating pharmacology of formylpeptide receptor 2 (FPR2; often referred to as FPR2/ALX since it binds lipoxin A4). Initially identified as a low-affinity ‘relative’ of FPR1, FPR2 presents…
Xi-Lu Hou, Cheng-Dong Ji, Jun Tang, Yan-Xia Wang + 11 more
'Hai-Qing Li' 'Wei-Wei Liu' 'Jiao-Xue Wang' 'He-Zhong Yan' 'Yan Wang' 'Peng Zhang' 'You-Hong Cui' 'Ji-Ming Wang' 'Xiu-Wu Bian' 'Wei Liu'] Formyl peptide receptor 2 (FPR2), a classical chemoattractant receptor of G-protein-coupled receptors, is reported to be involved in invasion and metastasis of some cancers, but the…
Chanbin Lee, Jinsol Han, Youngmi Jung
Formyl peptide receptors (FPRs), which are seven-membrane G-protein coupled receptors, recognize chemotactic signals to protect hosts from pathogenic infections and mediate inflammatory responses in the body. There are three isoforms of FPRs in humans-FPR1, FPR2, and FPR3-and they bind to N-formyl peptides, except…
Simon Lind, Martina Sundqvist, Rikard Holmdahl, Claes Dahlgren + 2 more
Despite the steadily increased numbers of formyl peptide receptor (FPR) ligands identified over the years, few have been characterized in studies using animal disease models and even less have entered clinical trials in human subjects. A small-molecule compound, Act-389949, was however recently tested in a phase I…
Brian Mun, Peter Obi, Christopher T. Szlenk, Senthil Natesan
Inflammation is essential to the body’s defense against tissue injury and microbial invasion. However, uncontrolled inflammation is highly detrimental and can result in chronic inflammatory diseases such as asthma, cancer, obesity, and diabetes. An increasing body of evidence suggests that specialized pro-resolving…
Christabel Fung-Yih Ho, Nadia Binte Ismail, Joled Kong-Ze Koh, Saravanan Gunaseelan + 4 more
'Saravanan Gunaseelan' 'Yi-Hua Low' 'Yee-Kong Ng' 'John Jia-En Chua' 'Wei-Yi Ong'] Arachidonic acid and docosahexaenoic acid (DHA) released by the action of phospholipases A2 (PLA2) on membrane phospholipids may be metabolized by lipoxygenases to the anti-inflammatory mediators lipoxin A4 (LXA4) and resolvin D1 (RvD1)…
Senthil A. Visaga, Harikesh Kalonia, Vinay Verma, Sandeep Sinha + 10 more
Formyl peptide receptor (FPR) family members have been reported to play important role in the resolution of inflammation. A few FPR2/FPR1 dual agonists are reported in the public domain for their anti-inflammatory properties. None of these molecules, however, have been successful as a therapy yet. Recent reports bring…
Martina Sundqvist, André Holdfeldt, Shane C. Wright, Thor C. Møller + 6 more
Formyl peptide receptor 2 (FPR2), a member of the family of G protein-coupled receptors (GPCRs), mediates neutrophil migration, a response that has been linked to β-arrestin recruitment. β-Arrestin regulates GPCR endocytosis and can also elicit non-canonical receptor signaling. To determine the poorly understood role…
Moa Viklund, Johanna Fredriksson, André Holdfeldt, Simon Lind + 4 more
Highly pathogenic Staphylococcus aureus strains produce phenol-soluble modulins (PSMs), peptides which are formylated N-terminally. Nanomolar concentrations of PSMα2 are recognized by formyl peptide receptor 2 (FPR2), but unlike the prototypic FPR2 agonist WKYMVM, PSMα2 is a biased signaling agonist. A shortened…
Denise Pajonczyk, Merle F. Sternschulte, Oliver Soehnlein, Marcel Bermudez + 2 more
Pattern Recognition Receptors are key in identifying pathogenic or damaged cell-related patterns or molecules. Among these, the closely linked formyl peptide receptors FPR1 and FPR2 are believed to hold pivotal yet differing functions in immune regulation. To address the intriguing question of how these highly related…
Nicole M. Paterson, Hussein Al-Zubieri, Joseph Ragona, Juan Tirado + 2 more
The detection of invasive pathogens is critical for host immune defense. Cell surface receptors play a key role in the recognition of diverse microbe-associated molecules, triggering leukocyte recruitment, phagocytosis, release of antimicrobial factors, and cytokine production. The intense selective forces acting on…
Devon Field, Stuart Warriner, Megan Wright
Fluorescent ligands for G-protein coupled receptors (GPCRs) are valuable tools for studying the expression, pharmacology and modulation of these therapeutically important proteins in living cells. Here we report a photocrosslinking fluorescent chemical probe for Formyl peptide receptor 1 (FPR1), a critical component of…
Yash Bhusare, Yogesh Maan, Ajay Kumar
Repeating FRBs Authors: ['Yash Bhusare' 'Yogesh Maan' 'Ajay Kumar'] The discovery of Persistent Radio Sources (PRSs) associated with three repeating fast radio bursts (FRBs) has provided insight into the local environments of these FRBs. Here, we present deep radio observations of the fields surrounding three highly…
Casey Law, Liam Connor, K.K. Aggarwal
The first Fast Radio Burst (FRB) to be precisely localized was associated with a luminous persistent radio source (PRS). Recently, a second FRB/PRS association was discovered for another repeating source of FRBs. However, it is not clear what makes FRBs or PRS or how they are related. We compile FRB and PRS properties…
Madeline Harper, Uma Nudurupati, Riley Workman, Taras Lakoba + 2 more
Using amylin(20-29) as a model system, we demonstrate that experimental constraints measured by Raman spectroscopy can be used to determine the molecular structure of amyloid fibrils. We employ polarized Raman spectroscopy measurements and the conformationally-sensitive Amide III3 mode to determine the distributions of…
J. D. Brandenburg, Yi-Tsung Chang, Jianjun Dong, Yu He + 19 more
'Huiting Huang' 'T. Q. Huang' 'H. Li' 'M. Nie' 'R. Sharma' 'Xiao Wei Sun' 'P. Tribedy' 'F. Videbæk' 'Gerhard H. Visser' 'G. Wilks' 'P. Wang' 'G. Xie' 'G. Yan' 'Z. Ye' 'L. Yi' 'Yutao Yang' 'S. Zhang' 'Z. Zhang'] The Forward Silicon Tracker (FST) is a pivotal component of the forward upgrade of the Solenoidal Tracker at…
Ziwei Wu, Robert Main, Weiwei Zhu, Bing Zhang + 20 more
We present the interstellar scintillation analysis of fast radio burst (FRB) 20220912A during its extremely active episode in 2022 using data from the Five-hundred-meter Aperture Spherical Radio Telescope (FAST). We detect a scintillation arc in the FRB's secondary spectrum, which describes the power in terms of the…
R. Gili, Jean‐Louis Prieur, Jean‐Pierre Rivet, F. Vakili + 2 more
'L. Koechlin' 'D. Bonneau'] UMS 2202, Université de Nice Sophia Antipolis – CNRS Observatoire de la Côte d'Azur, CS 34229, 06304 Nice Cedex 4, France CNRS – IRAP, 14 avenue E. Belin, 31400 Toulouse, France Université de Toulouse – UPS-OMP – IRAP, Toulouse, France UMR 7293, Université de Nice Sophia Antipolis – CNRS…
Mingyu Ge, Yuan-Pei Yang, F. J. Lu, Shiqi Zhou + 10 more
'Shuang‐Nan Zhang' 'Bing Zhang' 'Liang Zhang' 'Pei Wang' 'Kejia Lee' 'Weiwei Zhu' 'Jian Li' 'X. T. Hou' 'Qiao-Chu Li'] Fast radio bursts (FRBs) are short pulses observed in radio frequencies usually originating from cosmological distances. The discovery of FRB 200428 and its X-ray counterpart from the Galactic magnetar…
Julia Brüggemann, Maria Chekmeneva, Mario Wolter, Christoph Jacob
Two-dimensional infrared (2D-IR) spectroscopy is a powerful experimental method for probing the structure and dynamics of proteins in aqueous solution. So far, most experimental studies focus on the amide I vibrations, for which empirical vibrational exciton models provide a means of interpreting such experiments.…
Authors not listed
A substantial and growing body of research implicates protein‑arginine methyltransferases (PRMTs) in the pathogenesis of a range of human diseases, most prominently cancer. Their role – as oncoproteins or tumor suppressors – depends on both the cellular context and the specific type of malignancy. Starting from…
Richard Mandle
Given the widespread adoption of display technology based on nematic liquid crystals, the discovery of new nematic phases at thermodynamic equilibrium, although extremely rare, generates much excitement. The remarkable discovery polar order and giant ferroelectric polarisation in a nematic fluid is a watershed moment…