19 papers · ranked by Valyu relevance
Yue Guan, Leiting Dong, Satya N. Atluri
"Flexoelectricity" refers to a phenomenon which involves a coupling of the mechanical strain gradient and electric polarization. In this study, a meshless Fragile Points Method (FPM), is presented for analyzing flexoelectric effects in dielectric solids. Local, simple, polynomial and discontinuous trial and test…
Leiting Dong, Tian Yang, Kailei Wang, Satya N. Atluri
In this paper, a new method, named the Fragile Points Method (FPM), is developed for computer modeling in engineering and sciences. In the FPM, simple, local, polynomial, discontinuous and Point-based trial and test functions are proposed based on randomly scattered points in the problem domain. The local discontinuous…
Kailei Wang, Baoying Shen, Mingjing Li, Leiting Dong + 1 more
'Satya N. Atluri'] Notched components are commonly used in engineering structures, where stress concentration may easily lead to crack initiation and development. The main goal of this work is to develop a simple numerical method to predict the strength and crack-growth-path of U-notched specimens made of brittle…
Yue Guan, Satya N. Atluri
Three kinds of Fragile Points Methods based on Petrov-Galerkin weak-forms (PG-FPMs) are proposed for analyzing heat conduction problems in nonhomogeneous anisotropic media. This is a follow-up of the previous study on the original FPM based on a symmetric Galerkin weak-form. The trial function is piecewisecontinuous…
Viktor Könye, Ihor Nimyi, Oleg Janson, Jeroen van den Brink + 2 more
Some topological phases of matter are called fragile. They do not generically host protected gapless boundary states and they can be trivialized by adding additional valence bands. Here we show that fragile topology nevertheless has robust signatures: it yields bulk Dirac cones in two-dimensional materials with…
Lifeng Lin, Haitao Chu, Paul Aurelian Gagniuc
With the growing concerns about research reproducibility and replicability, the assessment of scientific results’ fragility (or robustness) has been of increasing interest. The fragility index was proposed to quantify the robustness of statistical significance of clinical studies with binary outcomes. It is defined as…
Adam Li, Chester Huynh, Zachary Fitzgerald, Iahn Cajigas + 15 more
Over 15 million epilepsy patients worldwide do not respond to drugs. Successful surgical treatment requires complete removal, or disconnection of the seizure onset zone (SOZ), brain region(s) where seizures originate. Unfortunately, surgical success rates vary between 30%-70% because no clinically validated biological…
Angela Re, Davide Cora, Alda Maria Puliti, Michele Caselle + 1 more
'Isabella Sbrana'] Background Common fragile sites (cfs) are specific regions in the human genome that are particularly prone to genomic instability under conditions of replicative stress. Several investigations support the view that common fragile sites play a role in carcinogenesis. We discuss a genome-wide approach…
Piotr Ordon, Ludwik Komorowski
. The theoretic foundations of the novel method for the comprehensive studies on the mechanism of the evolution of the electronic structure in a chemical reaction have been presented. Our method provides quantification for both the sequence of bond forming and breaking and the degree of bond (order) modifications along…
Cassandra L. Smith, Andrew Bolton, Giang Nguyen
Increasing evidence links genomic and epigenomic instability, including multiple fragile sites regions to neuropsychiatric diseases including schizophrenia and autism. Cancer is the only other disease associated with multiple fragile site regions, and genome and epigenomic instability is a characteristic of cancer.…
Rajesh Kumar, Gandharva Nagpal, Vinod Kumar, Salman Sadullah Usmani + 2 more
Genomic instability is the hallmark of cancer and several other pathologies, such as mental retardation; preferentially occur at specific loci in genome known as chromosomal fragile sites. HumCFS (http://webs.iiitd.edu.in/raghava/humcfs/) is a manually curated database provides comprehensive information on 118…
Jeffrey West, Bina Desai, Maximilian Strobl, Jill Gallaher + 3 more
A population of cells within a tumor can be described as antifragile (the opposite of fragile) if they derive a benefit from fluctuations or perturbations in environmental conditions induced by treatment. We hypothesized that treatment fluctuations may either promote (antifragile tumor) or inhibit (fragile tumor) the…
Satyaprakash Nayak, Saniya Salim, Deyan Luan, Michael Zai + 2 more
'Jeffrey D. Varner' 'Gustavo Stolovitzky'] Robustness, a long-recognized property of living systems, allows function in the face of uncertainty while fragility, i.e., extreme sensitivity, can potentially lead to catastrophic failure following seemingly innocuous perturbations. Carlson and Doyle hypothesized that…
Bogdan Lipuš, Borut Žalik
Most 3D point cloud watermarking techniques apply Principal Component Analysis (PCA) to protect the watermark against affine transformation attacks. Unfortunately, they fail in the case of cropping and random point removal attacks. In this work, an alternative approach is proposed that solves these issues efficiently.…
Luke Pierik, Patricia McDonald, Alexander R. A. Anderson, Jeffrey West
Drug dose response curves are ubiquitous in cancer biology, but these curves are often used to measure differential response in first-order effects: the effectiveness of increasing the cumulative dose delivered. In contrast, second-order effects (the variance of drug dose) are often ignored. Knowledge of second-order…
Kris Sankaran, Shuzhen Zhang, Chenab, Marina Meilă
Nonlinear dimensionality reduction methods like UMAP and t-SNE can help to organize high-dimensional genomics data into manageable low-dimensional representations, like cell types or differentiation trajectories. Such reductions can be powerful, but inevitably introduce distortion. A growing body of work has…
Mohammed S Khalil
Background Fingerprint recognition systems essentially require core-point detection prior to fingerprint matching. The core-point is used as a reference point to align the fingerprint with a template database. When processing a larger fingerprint database, it is necessary to consider the core-point during feature…
Joshua Meyers, Nathan Brown
De novo molecular design is effective for optimizing compounds with desirable properties in drug discovery. In the realm of chemoinformatics, population-based evolutionary approaches have been known for over a decade including those that use retrosynthetically inspired fragment-based workflows to to balance the…
Eric Hermes, Khachik Sargsyan, Habib Najm, Judit Zádor
We present a new algorithm for the optimization of molecular structures to saddle points on the potential energy surface using a redundant internal coordinate system. This algorithm automates the procedure of defining the internal coordinate system, including the handling of linear bending angles, e.g. through the…