17 papers · ranked by Valyu relevance
Dea Gogishvili, Madison I. J. Honey, Inge M. W. Verberk, Lisa Vermunt + 3 more
'Lisa Vermunt' 'Elly M. Hol' 'Charlotte E. Teunissen' 'Sanne Abeln'] Title: Abstract Glial fibrillary acidic protein (GFAP) is a well-established biomarker of reactive astrogliosis in the central nervous system because of its elevated levels following brain injury and various neurological disorders. The advent of…
Charlie T. Beales, Matthias Eibauer, Yolanda de Pablo, Simon B. Hansen + 4 more
GFAP filaments are core elements of the cytoskeleton in astrocytes, shaping cellular processes and influencing central nervous system function and pathology. How these filaments are built at the molecular level has remained unclear. Using cryo-electron microscopy and cryo-electron tomography, we show that GFAP…
Natalia Yunusova, Dmitry Svarovsky, Polina Panfilova, Anastasia Ryabova + 6 more
This review demonstrates that the diagnostic and prognostic significance of glial fibrillary acidic protein (GFAP) is not limited to its use as a marker of astrocytic damage but should also be considered in the context of the diversity of GFAP isoforms, their heterogeneous tissue-specific expression and their…
Emma J. van Bodegraven, Jacqueline A. Sluijs, A. Katherine Tan, Pierre A.J.T. Robe + 1 more
The glial fibrillary acidic protein (GFAP) is a type III intermediate filament (IF) protein that is highly expressed in astrocytes, neural stem cells, and in gliomas. Gliomas are a heterogeneous group of primary brain tumors that arise from glia cells or neural stem cells and rely on accurate diagnosis for prognosis…
Xiaoxiao Zheng, Jingyao Yang, Yiwei Hou, Xinye Shi + 1 more
Glial fibrillary acidic protein (GFAP), an intracellular type III intermediate filament protein, provides structural support and maintains the mechanical integrity of astrocytes. It is predominantly found in the astrocytes which are the most abundant subtypes of glial cells in the brain and spinal cord. As a marker…
Johann Zwirner, Julia Lier, Heike Franke, Niels Hammer + 4 more
'Jakob Matschke' 'Florian Trautz' 'Rexon Tse' 'Benjamin Ondruschka'] Glial fibrillary acidic protein (GFAP) is a well-established astrocytic biomarker for the diagnosis, monitoring and outcome prediction of traumatic brain injury (TBI). Few studies stated an accumulation of neuronal GFAP that was observed in various…
Sarah E. Boyd, Betina Nair, Sze Woei Ng, Jonathan M. Keith + 2 more
Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein specific to central nervous system (CNS) astrocytes. It has been the subject of intense interest due to its association with neurodegenerative diseases, and because of growing evidence that IF proteins not only modulate cellular structure…
Ina-Beate Wanner, Julia Halford, Jonathan Lopez, Sean Shen + 11 more
Glial fibrillary acidic protein (GFAP) is an important clinical biomarker of traumatic brain injury (TBI), yet understanding the nature, timing, and impact of its degraded and modified products is needed for clinical utility. We report distinct GFAP breakdown products (BDPs) and post-translational modifications (PTMs)…
Ni-Hsuan Lin, Wan-Syuan Jian, Natasha Snider, Ming-Der Perng
Here, we describe pathological events potentially involved in the disease pathogenesis of Alexander disease (AxD). This is a primary genetic disorder of astrocyte caused by dominant gain-of-function mutations in the gene coding for an intermediate filament protein glial fibrillary acidic protein (GFAP). Pathologically…
Aravinthan, Shamaley, Hu, Bin
This article was produced via WisdomWave AI Virtual Lab, an OpenDH research and training platform of human-AI collaborations (www.OpenDH.ca). The original study design, ideas and data collection and analysis architecture were from authors. Multiple foundational LLM models (OpenAI, Gemini, Grok and Kimi) were used…
Ina-Beate Wanner, Julia Halford, Jonathan Lopez, Sean Shen + 11 more
Monitoring patients with traumatic brain injury (TBI) is essential for mitigating secondary complications. TBI disrupts proteostasis, leading to increased protein degradation and proteinopathy, which heighten the risk of neurodegeneration and underscore the need for early detection via noninvasive biomarkers. Glial…
Marco Antônio De Bastiani, Bruna Bellaver, Wagner S. Brum, Debora G. Souza + 12 more
In Alzheimer’s disease clinical research, glial fibrillary acidic protein (GFAP) released into the cerebrospinal fluid and blood is widely measured and perceived as a biomarker of reactive astrogliosis. However, it was demonstrated that GFAP levels differ in individuals presenting with amyloid-β (Aβ) or tau pathology.…
Dimiter Prodanov, Jean Delbeke
The paper considers a model of anomalous diffusion occurring in the glial scar around a chronic implant in two simple geometries – a separable rectilinear electrode and a cylindrical electrode, which are solvable exactly. We describe a hypothetical extended source of diffusing species and study its concentration…
Mattia Bramini, Martina Chiacchiaretta, Andrea Armirotti, Anna Rocchi + 7 more
'Anna Rocchi' 'Deepali D. Kale' 'Cristina Martín' 'Ester Vázquez' 'Tiziano Bandiera' 'Stefano Ferroni' 'Fabrizia Cesca' 'Fabio Benfenati'] † Center for Synaptic Neuroscience and Technology and Graphene Labs, Istituto Italiano di Tecnologia, 16132 Genova, Italy; ÞIRCCS Ospedale Policlinico San Martino, 16132 Genova…
Martina Chiacchiaretta, Mattia Bramini, Anna Rocchi, Andrea Armirotti + 6 more
'Andrea Armirotti' 'Emanuele� Giordano' 'Ester Vázquez' 'Tiziano Bandiera' 'Stefano Ferroni' 'Fabrizia Cesca' 'Fabio Benfenati'] † Center for Synaptic Neuroscience and Technology and Graphene Labs, Istituto Italiano di Tecnologia, 16163 Genova, Italy; # Drug Discovery and Development and Graphene Labs, Istituto…
Authors not listed
Fibroblast Growth Factor 2 (FGF2) is a potent mitogen secreted from mammalian cells through an unconventional secretory pathway. This process is mediated by direct translocation of FGF2 across the plasma membrane into the extracellular space. It requires several components that are asymmetrically distributed between…
wenzhong liu, hualan li
Infection with the Zika virus results in severe neurological disease in adults or congenital Zika syndrome in newborns. We employed the domain search strategy to study the Zika virus glycoprotein E in this work. The results revealed that immature E contains a NGF domain…