13 papers · ranked by Valyu relevance
Jinxing Wang, Fangmin Chen, Xu Xiao, Xinyao Yang + 1 more
Bayesian phylogenetic analysis is essential for elucidating evolutionary relationships among organisms. Traditional methods often rely on fixed models and manual parameter settings, which can limit accuracy and efficiency. This protocol presents an integrated workflow that leverages GUIDANCE2 for rigorous sequence…
Christina Stoiber, Davide Ceneda, Markus Wagner, Victor Schetinger + 4 more
'Theresia Gschwandtner' 'Marc Streit' 'Silvia Miksch' 'Wolfgang Aigner'] Abstract—A typical problem in Visual Analytics (VA) is that users are highly trained experts in their application domains, but have mostly no experience in using VA systems. Thus, users often have difficulties interpreting and working with visual…
Maheshya Weerasinghe, Aaron Quigley, Klen Čopič Pucihar, Alice Toniolo + 2 more
Experiential learning (ExL) is a well-known learning approach used in education, training, facilitation, coaching and organisational development . ExL refers to the process of learning through experience or "learning by doing". One of the most influential models in ExL is the Kolb's learning model . This model defines…
Arpit Narechania, Alex Endert, Atanu R. Sinha
Analysts Impacts Visual Data Preparation and Analysis Authors: ['Arpit Narechania' 'Alex Endert' 'Atanu R. Sinha'] The progress in generative Artificial Intelligence (AI) has fueled AI-powered tools like co-pilots and assistants to provision better guidance, particularly during data analysis. However, research on…
Alex Odlum, Rosemary James, Audrey Mahieu, Karl Blanchet + 3 more
'Chiara Altare' 'Neha Singh' 'Paul Spiegel'] Background For humanitarian organisations to respond effectively to complex crises, they require access to up-to-date evidence-based guidance. The COVID-19 crisis has highlighted the importance of updating global guidance to context-specific and evolving needs in…
Harsh Kumar, Ilya Musabirov, Mohi Reza, Jiakai Shi + 4 more
'Joseph Jay Williams' 'Anastasia Kuzminykh' 'Michael Liut'] HARSH KUMAR, University of Toronto, Canada ILYA MUSABIROV, University of Toronto, Canada MOHI REZA, University of Toronto, Canada JIAKAI SHI, University of Toronto, Canada XINYUAN WANG, University of Toronto, Canada JOSEPH JAY WILLIAMS, University of Toronto…
Davide Ceneda, Christopher Collins, Mennatallah El‐Assady, Silvia Miksch + 2 more
'Silvia Miksch' 'Christian Tominski' 'Alessio Arleo'] Abstract—Guidance can support users during the exploration and analysis of complex data. Previous research focused on characterizing the theoretical aspects of guidance in visual analytics and implementing guidance in different scenarios. However, the evaluation of…
Hanqi Feng, Peng Qiu, Meng-Chun Zhang, Yiran Tao + 3 more
Recent advances in diffusion models have shown remarkable potential for antibody design, yet existing approaches apply uniform generation strategies that cannot adapt to each antigen’s unique requirements. Inspired by B cell affinity maturation—where antibodies evolve through multi-objective optimization balancing…
Authors not listed
Recent advances in structural biology have led to the publica- tion of a wealth of high resolution x-ray crystallography and cryo-EM macromolecule structures, including many complexes with small molecules of interest for drug design. While it is com- mon to incorporate information from the atomic coordinates of these…
Ben Davies, Joshua Parker
Healthcare practitioners have access to a range of ethical guidance. However, the normative role of this guidance in ethical decision-making is underexplored. This paper considers two ways that healthcare practitioners could approach ethics guidance. We first outline the idea of deference to ethics guidance, showing…
Finbarr C Martin, Terence J Quinn, Sharon E Straus, Sonia Anand + 2 more
'Nathalie van der Velde' 'Rowan H Harwood'] Title: Abstract Globally, more people are living into advanced old age, with age-associated frailty, disability and multimorbidity. Achieving equity for all ages necessitates adapting healthcare systems. Clinical practice guidelines (CPGs) have an important place in adapting…
Heather Ingold, Gabriela B. Gomez, David Stuckler, Anna Vassall + 1 more
In this stage, we uncovered five areas of tension including the composition of the GDG; complexity of GRADE; external validity and context; the use of other types of evidence; and the role of donors. While the establishment of the GRC and the use of GRADE aimed to ensure evidence-based recommendations, interviewees…
Mateo Reveiz, Myungjin Lee, Peter D. Kwong, Tongqing Zhou + 1 more
Glycans bound to glycoproteins mediate immune response, including antibody recognition and immune evasion. Previously, we developed an in silico tool GLYCO (GLYcan COverage) to quantify the glycan shielding of a protein surface, applying it to various studies. However, GLYCO lacks sufficient computational efficiency…