20 papers · ranked by Valyu relevance
Aurelien Pelissier, Maria Stratigopoulou, Naomi Donner, Evangelos Dimitriadis + 4 more
Germinal centers (GCs) are specialized compartments within the secondary lymphoid organs where B cells proliferate, differentiate, and mutate their antibody genes in response to the presence of foreign antigens. They play a central role in generating an effective immune response against infectious pathogens, and…
Megan Woods, Yong-Rui Zou, Anne Davidson
Germinal centers (GCs) are the primary site at which clonal expansion and affinity maturation of B cells occur. B cells encounter antigen and receive T cell help in the GC light zone (LZ) and then migrate to the dark zone where they proliferate and undergo somatic mutation before cycling back to the LZ for further…
Tom S Weber
Adaptation of antibody-mediated immunity occurs in germinal centers (GC). It is where affinity maturation, class switching, memory and plasma cell differentiation synergize to generate specific high affinity antibodies that help both to clear and protect against reinfection of invading pathogens. Within GCs, light and…
Niels J. M. Verstegen, Victor Ubels, Hans V. Westerhoff, S. Marieke van Ham + 1 more
'S. Marieke van Ham' 'Matteo Barberis'] Germinal center (GC) reactions are vital to the correct functioning of the adaptive immune system, through formation of high affinity, class switched antibodies. GCs are transient anatomical structures in secondary lymphoid organs where specific B cells, after recognition of…
Anupam Banerjee, Vishal Sindhava, Raja Vuyyuru, Vibha Jha + 4 more
'Suchita Hodewadekar' 'Tim Manser' 'Michael L. Atchison' 'Yolande Richard'] YY1 has been implicated as a master regulator of germinal center B cell development as YY1 binding sites are frequently present in promoters of germinal center-expressed genes. YY1 is known to be important for other stages of B cell development…
Ralph, Duncan K, Bakis, Athanasios G + 14 more
- 1 Fred Hutchinson Cancer Research Center, Seattle, Washington, USA - 2 Department of Statistics, University of California, Irvine, CA - 3 Department of Genome Sciences, University of Washington, Seattle, WA - 4 Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY - 5 Department of Statistics…
Michael Meyer-Hermann
Selection of B cells in germinal center (GC) reactions is pivotal to the generation of high affinity antibodies and memory B cells. Knowledge about B cell selection is limited to individual interactions and lacks global understanding. Here, seemingly contradictory experiments are unified in a common concept by…
Jong R Kim, Hyung W Lim, Seung G Kang, Peter Hillsamer + 1 more
Background The function of CD57+ CD4+ T cells, constituting a major subset of germinal center T (GC-Th) cells in human lymphoid tissues, has been unclear. There have been contradictory reports regarding the B cell helping function of CD57+ GC-Th cells in production of immunoglobulin (Ig). Furthermore, the cytokine and…
Doaa Waly, Aradana Muthupandian, Chia-Wei Fan, Harrison Anzinger + 1 more
'Brad G. Magor'] DNA mutagenesis during antibody affinity maturation has potentially oncogenic or autoimmune outcomes if not tightly controlled as it is in mammalian germinal centers. Cold blooded vertebrates lack germinal centers, yet have a functional Ig gene mutator enzyme, Aicda. In fish there are clusters of…
Adam J Fike, Sathi Babu Chodisetti, Nathaniel E Wright, Kristen N Bricker + 10 more
Germinal centers (GCs), sites of antibody affinity maturation, are organized into dark (DZ) and light (LZ) zones. Here, we uncovered a B cell intrinsic role for STAT3 in GC DZ and LZ organization. Altered zonal organization of STAT3-deficient GCs dampened GC output of long-lived plasma cells (LL-PCs) but increased…
Fiamma Salerno, Alex J. Whale, Louise S. Matheson, William S. Foster + 6 more
How germinal centre (GC) B cells undergo rapid cell division while maintaining genome stability is poorly understood. Here, we show that the RNA-binding proteins ZFP36L1 and ZFP36L2 act downstream of antigen-sensing and protect GC B cells from replication stress by controlling a cell cycle-related RNA…
Zishuo Yan, Hai Qi, Yueheng Lan
Germinal center (GC) is a particular biological structure produced for affinity maturation in the lymphoid follicle during the T-dependent immune response and is an important component of the humoral immune system. However, the impact of morphological features of the GC on antibody production is not clear. According to…
Stephen Lindsly, Maya R. Gupta, Alnawaz Rehemtulla, Indika Rajapakse
The mammalian adaptive immune system has evolved over millions of years to become an incredibly effective defense against foreign antigens. The adaptive immune system's humoral response creates plasma B cells and memory B cells, each with their own immunological objectives. The affinity maturation process is widely…
Vuk Milišić, Gilles Wainrib
Lymphocyte selection is a fundamental operation of adaptive immunity. In order to produce B-lymphocytes with a desired antigenic profile, a process of mutation-selection occurs in the germinal center, which is part of the lymph nodes. We introduce in this article a simplified mathematical model of this process, taking…
Federica Ferretti, Mehran Kardar
We introduce a novel, multi-scale model for affinity maturation, which aims to capture the intraclonal, inter-clonal and epitope-specific organization of the B cell population in a germinal center. We describe the evolution of the B cell population via a quasispecies dynamics, with species corresponding to unique B…
Henry A. Utset, Jenna J. Guthmiller, Patrick C. Wilson
The generation of high affinity antibodies is a crucial aspect of immunity induced by vaccination or infection. Investigation into the B cells that produce these antibodies grants key insights into the effectiveness of novel immunogens to induce a lasting protective response against endemic or pandemic pathogens, such…
Rachael Keating, Jenny L. Johnson, David C. Brice, Jocelyn G. Labombarde + 3 more
'Jocelyn G. Labombarde' 'Alexander L. Dent' 'Maureen A. McGargill' 'Thomas E. Morrison'] It is estimated that 250,000 to 650,000 individuals worldwide die each year from seasonal influenza A virus (IAV) infections. Current vaccines provide little protection against newly emerging strains. Thus, considerable effort is…
Debraj Ghose, Thomas C. Ferrante, Donald E. Ingber
Unlike most solid-like tissues, immune tissue is protean and reconfigurable—its component cells can patrol vast territories, find rare cellular partners, and dynamically self-organize into functional structures like germinal centers or tertiary lymphoid structures. The ability of immune cells to collectively behave as…
Bakis, Athanasios G., Vora, Ashni A. + 18 more
- 1 Department of Statistics, University of California, Irvine, CA, USA - 2 Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA - 3 Department of Genome Sciences, University of Washington, Seattle, WA, USA - 4 Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle…
Tamás Szabados, Csaba Kerepesi, Tibor Bakács
Our main purpose is to compare classical nonself-centered, two-signal theoretical models of the adaptive immune system with a novel, self-centered, one-signal model developed by our research group. Our model hypothesizes that the immune system of a fetus is capable learning the limited set of self antigens but unable…