21 papers · ranked by Valyu relevance
Aurelien Pelissier, Maria Stratigopoulou, Naomi Donner, Evangelos Dimitriadis + 4 more
Germinal centers (GCs) are specialized compartments within the secondary lymphoid organs where B cells proliferate, differentiate, and mutate their antibody genes in response to the presence of foreign antigens. They play a central role in generating an effective immune response against infectious pathogens, and…
Elisa Fleischmann, Vera Middelkamp, Theo van den Broek
Interactions between T- and B cells in the germinal center reaction are instrumental for the initiation, maintenance, and downregulation of the human adaptive immune response, leading to the production of antigen-specific antibodies and long-lasting immunological memory. Replicating the human immune system remains…
Ralph, Duncan K, Bakis, Athanasios G + 14 more
- 1 Fred Hutchinson Cancer Research Center, Seattle, Washington, USA - 2 Department of Statistics, University of California, Irvine, CA - 3 Department of Genome Sciences, University of Washington, Seattle, WA - 4 Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY - 5 Department of Statistics…
Derek P. Mu, Christopher D. Scharer, Norbert E. Kaminski, Qiang Zhang
The germinal center response or reaction (GCR) is a hallmark event of adaptive humoral immunity. Unfolding in the B cell follicles of the secondary lymph organs, a GC culminates in the production of high-affinity antibody-secreting plasma cells along with memory B cells. By interacting with follicular dendritic cells…
Doaa Waly, Aradana Muthupandian, Chia-Wei Fan, Harrison Anzinger + 1 more
'Brad G. Magor'] DNA mutagenesis during antibody affinity maturation has potentially oncogenic or autoimmune outcomes if not tightly controlled as it is in mammalian germinal centers. Cold blooded vertebrates lack germinal centers, yet have a functional Ig gene mutator enzyme, Aicda. In fish there are clusters of…
Haripriya Vaidehi Narayanan, Alexander Hoffmann
Antibody-mediated adaptive immunity must provide effective long-term protection with minimal adverse effects, against rapidly mutating pathogens, in a human population with diverse ages, genetics, and immune histories. In order to grasp and leverage the complexities of the antibody response, we advocate for a…
Marta Cakala-Jakimowicz, Paulina Kolodziej-Wojnar, Monika Puzianowska-Kuznicka, Juan Pablo de Rivero Vaccari
'Monika Puzianowska-Kuznicka' 'Juan Pablo de Rivero Vaccari'] Aging affects all tissues and organs. Aging of the immune system results in the severe disruption of its functions, leading to an increased susceptibility to infections, an increase in autoimmune disorders and cancer incidence, and a decreased response to…
Adam J Fike, Sathi Babu Chodisetti, Nathaniel E Wright, Kristen N Bricker + 10 more
Germinal centers (GCs), sites of antibody affinity maturation, are organized into dark (DZ) and light (LZ) zones. Here, we uncovered a B cell intrinsic role for STAT3 in GC DZ and LZ organization. Altered zonal organization of STAT3-deficient GCs dampened GC output of long-lived plasma cells (LL-PCs) but increased…
Fiamma Salerno, Alex J. Whale, Louise S. Matheson, William S. Foster + 6 more
How germinal centre (GC) B cells undergo rapid cell division while maintaining genome stability is poorly understood. Here, we show that the RNA-binding proteins ZFP36L1 and ZFP36L2 act downstream of antigen-sensing and protect GC B cells from replication stress by controlling a cell cycle-related RNA…
Alana Kirn, Kim L. Good‐Jacobson
Memory B cells are essential for long-lasting immunity induced by both encountered pathogens and vaccines. Functional diversity within the memory B cell pool is established through interactions between memory B cells and the environment in which they develop and reside. This review will discuss novel insights into the…
Federica Ferretti, Mehran Kardar
We introduce a novel, multi-scale model for affinity maturation, which aims to capture the intraclonal, inter-clonal and epitope-specific organization of the B cell population in a germinal center. We describe the evolution of the B cell population via a quasispecies dynamics, with species corresponding to unique B…
Cade R. Rahlf, Christopher N. Jondle, Erika R. Johansen, Vera L. Tarakanova + 1 more
Gammaherpesviruses infect >90% of adults and are associated with B cell lymphomas. These viruses drive the expansion and differentiation of germinal center B cells to amplify latent viral reservoir and ensure life-long infection of memory B cells. Additionally, infected germinal center B cells seed viral…
Debraj Ghose, Thomas C. Ferrante, Donald E. Ingber
Unlike most solid-like tissues, immune tissue is protean and reconfigurable—its component cells can patrol vast territories, find rare cellular partners, and dynamically self-organize into functional structures like germinal centers or tertiary lymphoid structures. The ability of immune cells to collectively behave as…
Pankaj Sharma, Xiaolong Zhang, Kevin Ly, Yuxiang Zhang + 13 more
Influenza viruses escape immunity due to rapid antigenic evolution, which requires vaccination strategies that allow for broadly protective antibody responses. Here, we demonstrate that the lipid globotriaosylceramide (Gb3) expressed on germinal center (GC) B cells is essential for the production of high-affinity…
Bakis, Athanasios G., Vora, Ashni A. + 18 more
- 1 Department of Statistics, University of California, Irvine, CA, USA - 2 Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA - 3 Department of Genome Sciences, University of Washington, Seattle, WA, USA - 4 Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle…
Damon L. Schmalzriedt, Erika R. Johansen, Carlie A. Aurubin, Cade R. Rahlf + 4 more
'Cade R. Rahlf' 'Bradey Stuart' 'Daisy Sahoo' 'Vera L. Tarakanova' 'Felicia Goodrum'] Title: ABSTRACT Lipid metabolism has emerged as an important regulator of acute viral infections by affecting viral replication and the host immune response. In contrast, the role of host lipid metabolism during chronic viral…
Bertrand Ottino-Löffler, Gabriel D. Victora
A central feature of vertebrate immune response is affinity maturation, wherein antibodyproducing B cells undergo evolutionary selection in microanatomical structures called germinal centers, which form in secondary lymphoid organs upon antigen exposure. While it has been shown that the median B cell affinity…
Hongda Jiang, Shenshen Wang
The adaptive immune system constantly remodels its lymphocyte repertoire for better protection against future pathogens. Its ability to improve antigen recognition on the fly relies on somatic mutation and selective expansion of B lymphocytes expressing high-affinity antigen receptors. However, this Darwinian process…
Claudia Teufel, Anna-Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner + 12 more
In the past decades, vaccine development has made great strides. Nevertheless, more often than not, vaccine candidates fail in advanced stages of development and clinical trials. A key reason is the poor predictive value of non-clinical in vivo and in vitro models, due to either species-specific differences in the…
Karīna Siliņa, Francesco Ciompi
images: manual and deep learning-based quantification approaches Authors: ['Karīna Siliņa' 'Francesco Ciompi'] QuanAficaAon of lymphoid aggregates including terAary lymphoid structures with germinal centers in histology images of cancer is a promising approach for developing prognosAc and predicAve Assue biomarkers. In…
Saeed Mahdisoltani, Pranav Murugan, Arup K. Chakraborty, Mehran Kardar
'Mehran Kardar'] A persistent public health challenge is finding immunization schemes that are effective in combating highly mutable pathogens such as HIV and influenza viruses. To address this, we analyze a simplified model of affinity maturation, the Darwinian evolutionary process B cells undergo during immunization.…