25 papers · ranked by Valyu relevance
Anusha Gauba, Khondaker Miraz Rahman
Multidrug-resistant Gram-negative bacterial infections are exponentially increasing, posing one of the most urgent global healthcare and economic threats. Due to the lack of new therapies, the World Health Organization classified these bacterial species as priority pathogens in 2017, known as ESKAPE pathogens. This…
Authors not listed
The United Nations have committed to end the epidemics of communicable diseases by 2030 (SDG Target 3.3). In contrast with this ambition, the rise of Multi Drug Resistant (MDR) and Pan Drug Resistant (PDR) bacteria poses a threat of a return to the pre-antibiotic era. It is of high priority to find new therapies that…
Yasin Desalegn, Adane Bitew, Amanuel Adane
Background In developing countries, the co-existence of a high burden of infectious diseases caused by Gram-negative bacteria and the rapid increase and spread of multidrug-resistant bacteria have become a serious health threat. Objective Profiling of Gram-negative bacteria and determining the magnitude of their…
Alok Bharadwaj, Amisha Rastogi, Swadha Pandey, Saurabh Gupta + 1 more
'Jagdip Singh Sohal'] In the present scenario, resistance to antibiotics is one of the crucial issues related to public health. Earlier, such resistance to antibiotics was limited to nosocomial infections, but it has now become a common phenomenon. Several factors, like extensive development, overexploitation of…
Jessica K. Choi, Saroj Poudel, Nathan Yee, Jennifer L. Goff + 1 more
The Gram staining method differentiates bacteria based on their cell envelope structure, with the monoderm and diderm cell envelope types traditionally being synonymous with Gram-positive and Gram-negative stain results, respectively. Monoderms have a single phospholipid membrane surrounded by a thick layer of…
Joshi, Pritish, Patra, Niladri
| Chapters | Titles | | | | Page | No. | | --- | --- | --- | --- | --- | --- | --- | | Chapter 1 | Introduction | | | | 01-06 | | | 1.1 | Bacterial | stains | | | 01 | | | 1.2 | Antibiotics | | | | 01-02 | | | 1.3 | ESKAPE | Pathogens | | | 02 | | | 1.4 | Mechanisms | of antimicrobial | | resistance | 03-06 | | | |…
Golbarg Gazerani, Lesley R. Piercey, Syeda Reema, Katie A. Wilson
The World Health Organization has identified multidrug-resistant bacteria as a serious global health threat. Gram-negative bacteria are particularly prone to antibiotic resistance, and their high rate of antibiotic resistance has been suggested to be related to the complex structure of their cell membrane. The outer…
Aliaksandr Zhydzetski, Zuzanna Głowacka-Grzyb, Kinga Chlebicka, Benedykt Władyka
The widespread emergence of multidrug-resistant pathogenic bacteria across various environments, healthcare settings, and food industries, combined with the development of new methods to combat them, highlights the need for more precise, rapid, and cost-effective pathogen detection techniques. This is especially…
Ghazal Rashidi, Elizabeth A. Ostrowski
Professional phagocytes detect, pursue, engulf, and kill bacteria. While all professional phagocytes use chemotaxis to locate bacteria, little is known about whether they can discriminate among them, responding preferentially to some bacteria over others. Here we examine the chemotaxis of the soil amoeba and…
Begüm Koca, Özgür B. Akan
—Concurrent with advancements in molecular communication (MC), bacterial communication is emerging as a key area of interest. Given the frequent use of bacteria in various MC models, it is essential to have a thorough grasp of their intrinsic communication, signaling, and engineering techniques. Although it is crucial…
Abi S Ghifari
Pathogenic Gram-negative bacteria have developed resistance to antibiotics due to their ability in creating an envelope on the outer layer of lipooligosaccharides (LOS). The cationic phosphoethanolamine (PEA) decoration of LOS lipid A is regulated by lipid A–PEA transferase (EptA) which may serve as a prominent target…
M. K. K. Fazlul, Shah Samiur Rashid, Nazmul Mhm, Md. Zaidul Islam Sarker + 2 more
'Md. Zaidul Islam Sarker' 'Baharudin Roesnita' 'Aizi Nor Mazila Ramli'] Antibiotics are the wonder discoveries to combat microbes. For decades, multiple varieties of antibiotics have been used for therapeutic purposes in hospital settings and communities throughout the world. Unfortunately, bacteria have become…
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Developing new classes of antimicrobials that are active against Gram-negative bacteria is vital to combat the rising threat of antimicrobial resistance. “Trojan Horse” strategies, where antibiotics are conjugated to siderophores to enable penetration of the outer membrane of Gram-negative bacteria by hijacking the…
Karthikeyan Kandasamy, Miftakhul Jannatin, Yu-Chie Chen
Escherichia coli O157:H7 and Staphylococcus aureus are common pathogens. Gram-negative bacteria, such as E. coli, contain high concentrations of endogenous peroxidases, whereas Gram-positive bacteria, such as S. aureus, possess abundant endogenous catalases. Colorless 3,5,3′,5′-tetramethyl benzidine (TMB) changes to…
Meishan Wu, Rachael M. Harrower, Ziang Li, Angela C. Brown
The development of novel antimicrobial agents that are effective against Gram-negative bacteria is hindered by the dual membrane cell wall structure of these bacteria. To reach their intracellular targets, most antibiotics must therefore pass through protein channels called porins; however, a common mechanism of…
Amrita Ray Mohapatra, Divya Lakshmanan, Kadirvelu Jeevaratnam
Community-acquired infections are partly attributed to biofilms formed by drug resistant bacteria signifying major health problems. Hence, there is a critical need for the development of new antibiotics with antibacterial activities. In this study, we investigated the biofilm inhibiting characteristics of antibacterial…
Sheshadri S Temkar, Tarun M, Seema Tharannum, Dinesh M S
Nigella sativa is a medicinal plant used for its antimicrobial properties. Thymoquinone (TQ) being the lead component of this plant seeds, exerts antibacterial, antifungal and antioxidant activity. It has also shown promising activity against cancer and inflammation through different modes of action. In recent…
Christopher T. French, Philip Bulterys, Javier Ceja-Navarro, David Deshazer + 1 more
The Burkholderia pseudomallei complex (Bpc) includes B. pseudomallei, B. mallei and B. thailandensis. These species share conserved virulence determinants that facilitate survival in mammalian cells and can spread from cell to cell by a unique mechanism involving fusion of plasma membranes. The activity of a…
Çağatay Işıl, Hatice Ceylan Koydemir, Merve Eryılmaz, Kevin de Haan + 7 more
and deep learning Authors: ['Çağatay Işıl' 'Hatice Ceylan Koydemir' 'Merve Eryılmaz' 'Kevin de Haan' 'Nir Pillar' 'Koray Mentesoglu' 'Aras Firat Unal' 'Yair Rivenson' 'Sukantha Chandrasekaran' 'Omai B. Garner' 'Aydogan Özcan'] Gram staining has been one of the most frequently used staining protocols in microbiology for…
Rahwa Taddese, Clara Belzer, Steven Aalvink, Marien I. de Jonge + 3 more
There are many approaches available to inactivate bacteria, each with a different efficacy, impact on cell integrity, and potential for application in high-throughput. The aim of this study was to compare these approaches and develop a standardized protocol for generation of intact Gram-positive as well as on…
Buthaina Jubeh, Zeinab Breijyeh, Rafik Karaman
The discovery of antibiotics has created a turning point in medical interventions to pathogenic infections, but unfortunately, each discovery was consistently followed by the emergence of resistance. The rise of multidrug-resistant bacteria has generated a great challenge to treat infections caused by bacteria with the…
Krittika Ralhan, Kavita Iyer, Leilani Lotti Diaz, Robert Bird + 1 more
Developing effective antibacterial solutions has become paramount in maintaining global health in this era of increasing bacterial threats and rampant antibiotic resistance. Traditional antibiotics have played a significant role in combating bacterial infections throughout history. However, the emergence of novel…
Authors not listed
Microbial bioelectronic devices using electroactive bacteria provide robust, low-cost, and sustainable solutions for sensing, power generation, and chemical production. While most rely on a limited group of Gram-negative bacteria, Gram-positive species offer devices with additional functionality and broader…
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Background: Antimicrobial peptides (AMPs) of bacterial origin are considered as a promising alternative to traditional antibiotics and a good solution to the problem of antibiotic resistance. Additionally, many of them exhibit other types of biological activity. Therefore, in recent years, the interest of researchers…
Sebastian Jusuf, Pu-Ting Dong, Jie Hui, Erlinda R. Ulloa + 2 more
Streptococcus agalactiae, also known as Group B Streptococcus (GBS), is increasingly recognized as a major cause of soft tissue and invasive diseases in the elderly and diabetic populations. Antibiotics like penicillin are used with great frequency to treat these infections, although antimicrobial resistance is…