25 papers · ranked by Valyu relevance
Yashvardhan Batta, Cody King, Farion Cooper, John Johnson + 4 more
'Natasha Haddad' 'Myriam G. Boueri' 'Ella DeBerry' 'Georges E. Haddad'] With reports of its emergence as far back as the early 1900s, human immunodeficiency virus (HIV) has become one of the deadliest and most difficult viruses to treat in the era of modern medicine. Although not always effective, HIV treatment has…
Meihua Jin, Zhongrong Yang, Jing Li, Xiaoqi Liu + 1 more
Background Highly active antiretroviral therapy (HAART) can effectively reduce the risk of death and opportunistic infections in patients with HIV/AIDS. The aim of this study was to analyse the survival status and its influencing factors in HIV/AIDS after HAART. Methods The data on patients' sociodemographic…
Alexander Muacevic, John R Adler, Ishan Antony, Vishmita Kannichamy + 4 more
'Amit Banerjee' 'Arohi B Gandhi' 'Sharathshiva Valaiyaduppu Subas' 'Pousette Hamid'] HIV has been related to various cardiovascular pathologies in both adults and children. Highly active antiretroviral therapy (HAART) has been effective in subduing viral replication and improving immunity thereby reducing the effects…
Aklilu Endalamaw, Mengistu Mekonen, Demeke Geremew, Fekadu Ambaw + 2 more
The pooled burden of HIV treatment failure and its associated factors in Ethiopian context is required to provide evidence towards renewed ambitious future goal. PubMed, Web of Science, Scopus, Google Scholar, and Ethiopian Universities’ (University of Gondar and Addis Ababa University) online repository library were…
Yayah Emerencia Ngah, Frederick Nchang Cho, Bisong Shauna Etagha, Neh Gladys Fusi + 3 more
The incidence of hepatotoxicity is life-threatening and can result to an end-stage liver disease in long-term patients on combined antiretroviral therapy (cART). Our study sought to evaluate the incidence and predictors of cART-induced hepatotoxicity (CIH) among long term users on cART in a rural District hospital.…
Alexander Muacevic, John R Adler, Saritha Madham, J Visshishta + 3 more
'Haritha Dasagari Vinod' 'Ojass Kumar S' 'Vishnu Priya Cherukuri'] Human immunodeficiency virus (HIV) is a retrovirus that causes an infection affecting immunity-providing white blood cells. The HIV pandemic is far from over and is a major socio-economical burden. As there is no cure yet, prevention of new infections…
Ana Valadão, Paula Pezutto, Viviane A. Oliveira Silva, Barbara Simonson Gonçalves + 11 more
Euphorbia umbellata (E. umbellata) belongs to Euphorbiaceae family popularly known in Brazil as Janauba and contains in its latex a combination of phorbol esters with a strong affinity to different PKC isoforms. In this work we could show the presence of 4 deoxi-phorbol esters able to reactivate HIV latency through…
Shabani Ramadhani Mziray, Happiness H Kumburu, Hellen B Assey, Tolbert B Sonda + 3 more
Drug resistance is a public health concern. Profiles of HIV drug resistance mutations (HIVDRM) and virological failure (VF) are not extensively studied in Tanzania. This study aimed to determine HIVDRM and predictors of VF in HIV-infected individuals failing first-line HIV drugs in Moshi, northern Tanzania. A…
Maria E. Cilento, Eleftherios Michailidis, Tatiana V. Ilina, Eva Nagy + 4 more
4’-ethynyl-2-fluoro-2’-deoxyadenosine (EFdA, MK-8591, islatravir) is a nucleoside reverse transcriptase translocation inhibitor (NRTTI) with exceptional potency against WT and drug-resistant HIV strains. However, HIV resistance to EFdA is not well characterized. We therefore developed resistance to EFdA by serial…
Alexander Muacevic, John R Adler, Achyut Wadkar, Akash More
Human immunodeficiency virus (HIV) is a virus that affects the immune system and attacks immune cells called CD4 while also raising the risk and severity of other infections and diseases. Despite the fact that HIV can infect persons of any age, the majority of infected people are those of reproductive age between 15…
João P. S. Maurício de Carvalho
HIV is known for causing the destruction of the immune system by affecting different types of cells, while SARS-CoV-2 is an extremely contagious virus that leads to the development of COVID-19. In this study, we propose a mathematical model to investigate the interaction between HIV and SARS-CoV-2 under highly active…
Shu Yang, Judith J. Lok
Coarse structural nested mean models provide a useful tool to estimate treatment effects from longitudinal observational data with time-dependent confounders. However there is no existing guidance to specify the treatment effect model, and model misspecification can lead to biased estimators, preventing valid…
Elijah Paintsil
Twenty-nine years into the HIV epidemic, several advances have been made; however, there remain several challenges particularly with pediatric HIV in resource-limited countries. The obstacles facing pediatric antiretroviral therapy (ART) delivery in resource-limited countries are multifaceted: lack of health care…
Jayodita C. Sanghvi, Don Mai, Adam P. Arkin, David V. Schaffer
Multiple mechanisms in the HIV lifecycle play a role in its ability to evade therapy and become a chronic, difficult-to-treat infection. Within its major cellular target, the activated T cell, many steps occur between viral entry and viral burst, including reverse transcription of viral RNA, integration of the viral…
Mélanie Prague, Daniel Commenges, J. M. Gran, Bruno Ledergerber + 3 more
'Jim Young' 'Hansjakob Furrer' 'Rodolphe Thiébaut'] Summary: Highly active antiretroviral therapy (HAART) has proved efficient in increasing CD4 counts in many randomized clinical trials. Because randomized trials have some limitations (e.g., short duration, highly selected subjects), it is interesting to assess it…
Gexin Liu, Chunlin Zhang, Lei Shi, Zhenglin Zhu
There are individuals naturally resistant to HIV. To identify anti-HIV genes and regulatory networks that enable the native ability to resist HIV, we reanalyzed the transcriptome of HIV resistant and susceptible individuals based on previous efforts, and performed regulatory network prediction using HIV-infection…
Naeem Abdul Ghafoor, Ömür Baysal, Barış Ethem Süzek, Ragıp Soner Silme
The HIV epidemic has claimed more than 32.7 million live since its emergence in 1981, while many ART and HAART therapies are available and provide relief and control for patients, most of these therapeutics come with long-term side effects, resistance, socio-economical barriers, and other obstacles. In this study…
Steven E Lipshultz, Tracie L Miller, James D Wilkinson, Gwendolyn B Scott + 3 more
(HIV) infection is a primary cause of acquired heart disease, particularly of accelerated atherosclerosis, symptomatic heart failure, and pulmonary arterial hypertension . Cardiac complications often occur in the later stages of HIV infection with prolonged viral infection and are therefore becoming more relevant as…
Stephen Pankavich
One way in which the human immunodeficiency virus (HIV-1) replicates within a host is by infecting activated CD4+ T-cells, which then produce additional copies of the virus. Even with the introduction of antiretroviral drug therapy, which has been very successful over the past decade, a large obstacle to the complete…
Reuben Granich, Ying-Ru Lo, Amitabh B Suthar, Marco Vitoria + 11 more
'Rachel Baggaley' 'Carla Makhlouf Obermeyer' 'Craig McClure' 'Yves Souteyrand' 'Jos Perriens' 'James G Kahn' 'Rod Bennett' 'Caoimhe Smyth' 'Brian Williams' 'Julio Montaner' 'Gottfried Hirnschall'] After 30 years we are still struggling to address a devastating HIV pandemic in which over 25 million people have died. In…
Brian Williams, Renier van Rooyen, Martin Nieuwoudt
In most countries CD4+ cell counts are still used for deciding when to start HIV-positive people on anti-retroviral therapy. However, various CD4+ thresholds, 200, 350 or 500/μL, are chosen arbitrarily and for historical reasons. Here we consider the optimal CD4+ threshold at which asymptomatic HIV-positive people…
Mustafa Arif, Gaurav Sharma
HIV (human immunodeficiency virus) is a virus that attacks the immune system, which serves as the body’s defense mechanism. If untreated, HIV can lead to AIDS (acquired immunodeficiency syndrome), which raises risk for a host of problems, especially infections and cancers. According to data from 2022, there are 39…
Authors not listed
Neglected tropical diseases caused by trypanosomatid parasites such as Leishmania, Trypanosoma brucei and Trypanosoma cruzi present a major public healthcare issue due in part to emerging resistance. Exploring multiple targeting ligands, conjugates composed of analogs from the ribosomal inhibitor anisomycin and…
Brian Williams
The development of potent drugs for the control of viraemia in people living with HIV means that infected people may live a normal, healthy life and offers the prospect of eliminating HIV transmission in the short term and HIV infection in the long term. Other interventions, including the use of condoms, pre-exposure…
Sinem Koseoglu, Cansu Yenici, Sena Celikbas, Serra Aygun + 3 more
HIV-1 Tat (transactivator of transcription) protein is the main arsenal of HIV, playing numerous roles during viral infection. This protein is inherently disordered, lacking any secondary structures. This plasticity allows HIV-1 Tat to engage in interaction with multiple proteins and biological molecules, resulting in…