20 papers · ranked by Valyu relevance
Yashvardhan Batta, Cody King, Farion Cooper, John Johnson + 4 more
'Natasha Haddad' 'Myriam G. Boueri' 'Ella DeBerry' 'Georges E. Haddad'] With reports of its emergence as far back as the early 1900s, human immunodeficiency virus (HIV) has become one of the deadliest and most difficult viruses to treat in the era of modern medicine. Although not always effective, HIV treatment has…
Meihua Jin, Zhongrong Yang, Jing Li, Xiaoqi Liu + 1 more
Background Highly active antiretroviral therapy (HAART) can effectively reduce the risk of death and opportunistic infections in patients with HIV/AIDS. The aim of this study was to analyse the survival status and its influencing factors in HIV/AIDS after HAART. Methods The data on patients' sociodemographic…
Siqiniseko S. Ndlovu, Terisha Ghazi, Anil A. Chuturgoon, Philippe Gallay
'Philippe Gallay'] Highly active antiretroviral therapy (HAART) comprises a combination of two or three antiretroviral (ARV) drugs that are administered together in a single tablet. These drugs target different steps within the human immunodeficiency virus (HIV) life cycle, providing either a synergistic or additive…
Sodiq Kolawole Lawal, Samuel Oluwaseun Olojede, Ayobami Dare, Oluwaseun Samuel Faborode + 4 more
The inception of highly active antiretroviral therapy (HAART) has changed the management of human immunodeficiency virus (HIV) positive patients, with an improvement in life expectancy. However, neurological complications associated with high dosage and chronic administration of HAART have not been fully addressed.…
Alexander Muacevic, John R Adler, Saritha Madham, J Visshishta + 3 more
'Haritha Dasagari Vinod' 'Ojass Kumar S' 'Vishnu Priya Cherukuri'] Human immunodeficiency virus (HIV) is a retrovirus that causes an infection affecting immunity-providing white blood cells. The HIV pandemic is far from over and is a major socio-economical burden. As there is no cure yet, prevention of new infections…
Desiana Radithia, Ajiravudh Subarnbhesaj, Nurina-Febriyanti Ayuningtyas, Reiska-Kumala Bakti + 5 more
'Nurina-Febriyanti Ayuningtyas' 'Reiska-Kumala Bakti' 'Fatma-Yasmin Mahdani' 'Aulya-Setyo Pratiwi' 'Naqiya Ayunnisa' 'Salsabila-Fitriana Putri' 'Selviana-Rizky Pramitha'] Background Human Immunodeficiency Virus (HIV) infects patients via CD4+ cells which are later be destroyed subsequently causing the deteriotation of…
Alexander Muacevic, John R Adler, Achyut Wadkar, Akash More
Human immunodeficiency virus (HIV) is a virus that affects the immune system and attacks immune cells called CD4 while also raising the risk and severity of other infections and diseases. Despite the fact that HIV can infect persons of any age, the majority of infected people are those of reproductive age between 15…
João P. S. Maurício de Carvalho
HIV is known for causing the destruction of the immune system by affecting different types of cells, while SARS-CoV-2 is an extremely contagious virus that leads to the development of COVID-19. In this study, we propose a mathematical model to investigate the interaction between HIV and SARS-CoV-2 under highly active…
Maria E. Cilento, Xin Wen, Aaron B. Reeve, Obiaara Ukah + 11 more
Tenofovir disoproxil fumarate (TDF) and islatravir (ISL, 4’-ethynyl-2-fluoro-2’-deoxyadensine, or MK-8591) are highly potent nucleoside reverse transcriptase inhibitors. Resistance to TDF and ISL is conferred by K65R and M184V, respectively. Furthermore, K65R and M184V increase sensitivity to ISL and TDF, respectively.…
Madhusudan Rajendran, Maureen C. Ferran, Leora Mouli, Eric Everingham + 2 more
The HIV-1 protease is one of several common key targets of combination drug therapies for human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS). During the progression of the disease, some individual patients acquire -drug resistance due to mutational hotspots on the viral proteins…
A. Perna, M.A. Carleo, S. Mascolo, A. Guida + 10 more
Integrase strand transfer inhibitors (INSTI) are a recently available class of antiretroviral therapy (ART) medications with a good tolerability profile and a high genetic barrier to HIV drug resistance. However, several studies report more significant weight gain among persons receiving INSTI-based ART regimens for…
Janet Sasso, Barbara Ambrose, Rumiana Tenchov, Ruchira Datta + 3 more
In the last decade, there has been a shift in research, clinical development, and commercial activity to exploit the many roles of RNA in physiology for use in medicine. With the rapid success in the development of lipid-RNA nanoparticles for mRNA vaccines against COVID-19 and with several approved RNA-based drugs, RNA…
Yuki Tatekoshi, Chunlei Chen, Jason Shapiro, Hsiang-Chun Chang + 7 more
Heart failure with preserved ejection fraction (HFpEF) is commonly found in persons living with HIV (PLWH) even when antiretroviral therapy (ART) suppresses HIV viremia. However, studying this condition has been challenging because an appropriate animal model is not available. In this paper, we studied calcium…
Mustafa Arif, Gaurav Sharma
HIV (human immunodeficiency virus) is a virus that attacks the immune system, which serves as the body’s defense mechanism. If untreated, HIV can lead to AIDS (acquired immunodeficiency syndrome), which raises risk for a host of problems, especially infections and cancers. According to data from 2022, there are 39…
Mesfin Asfaw Taye
In our earlier work, we modeled the stochastic initiation of HIV rebound by treating latent-cell reactivation as a Poisson-driven process during antiretroviral-therapy (ART) washout, immune modulation, and therapeutic perturbation~\cite{Taye2025CM}. That framework characterized activation survival, cumulative hazards…
Authors not listed
Neglected tropical diseases caused by trypanosomatid parasites such as Leishmania, Trypanosoma brucei and Trypanosoma cruzi present a major public healthcare issue due in part to emerging resistance. Exploring multiple targeting ligands, conjugates composed of analogs from the ribosomal inhibitor anisomycin and…
Mesfin Taye
Due to the persistence of latently infected CD4+ T cells, achieving a functional cure for HIV-1 remains a significant challenge since the viruses are able to evade immune clearance, which in turn enables post-treatment viral rebound. Because traditional deterministic models assume a constant reactivation rate, they…
Hector F. Pelaez-Prestel, Juan Mozas-Gutierrez, Esther M. Lafuente, Pedro A. Reche
Human Immunodeficiency Virus (HIV) is a retrovirus that attacks the immune system, causing acquired immunodeficiency syndrome (AIDS). Early diagnosis and treatment of HIV infected individuals are considered key to reduce HIV transmission and developing AIDS. Therefore, HIV diagnostics play an important role in the…
Colin H. LaMont, Jakub Otwinowski, Kanika Vanshylla, Henning Gruell + 2 more
'Florian Klein' 'Armita Nourmohammad'] Broadly neutralizing antibodies (bNAbs) are promising targets for vaccination and therapy against HIV. Passive infusions of bNAbs have shown promise in clinical trials as a potential alternative for anti-retroviral therapy. A key challenge for the potential clinical application of…
Sinem Koseoglu, Cansu Yenici, Sena Celikbas, Serra Aygun + 3 more
HIV-1 Tat (transactivator of transcription) protein is the main arsenal of HIV, playing numerous roles during viral infection. This protein is inherently disordered, lacking any secondary structures. This plasticity allows HIV-1 Tat to engage in interaction with multiple proteins and biological molecules, resulting in…