24 papers · ranked by Valyu relevance
Anna-Karina Felder, Sjoerd J.D. Tjalsma, Han J.M.P. Verhagen, Rezin Majied + 8 more
The human genome contains regulatory DNA elements, enhancers, that can activate gene transcription over long chromosomal distances. Here, we show that enhancer distance can be critical for gene silencing. We demonstrate that linear recruitment of the normally distal HBB super-enhancer to developmentally silenced HBG…
Nanyu Wang, Ke Yang, Xuemin Xie, Shenshen Cui + 12 more
The γ- to β-globin switch is intricately regulated during human ontogeny, and this process is manipulated for therapeutic approaches to treat β-hemoglobinopathies by activating γ-globin expression. Several genetic strategies to reactivate HbF have partially reversed the γ- to β-globin switch and ameliorated the…
Ni Zhang, Z. Cao
Existing GFlowNet-based methods for vehicle routing problems (VRPs) typically employ Trajectory Balance (TB) to achieve global optimization but often neglect important aspects of local optimization. While Detailed Balance (DB) addresses local optimization more effectively, it alone falls short in solving VRPs, which…
Nithin Sam Ravi, Beeke Wienert, Stacia K. Wyman, Jonathan Vu + 11 more
Switching hemoglobin synthesis from defective adult beta-globin to fetal gamma-globin is an effective strategy for the treatment of beta-hemoglobinopathies. Fetal hemoglobin expression is down-regulated in the postnatal period due to the interplay of transcription regulators with the HBG promoters. However, in the…
Mandy Boontanrart, Gautier Stehli, Marija Banovic, Markus S. Schröder + 6 more
Fetal development and anemias such as β-hemoglobinopathies trigger rapid production of red blood cells in a process known as stress erythropoiesis. Cellular stress prompts differentiating erythroid precursors to express high levels of fetal γ-globin, which has suggested strategies to treat hemoglobinopathies such as…
Clemens Mingels, Luis Weissenrieder, Konstantinos Zeimpekis, Hasan Sari + 5 more
'Hasan Sari' 'Lorenzo Nardo' 'Federico Caobelli' 'Ian Alberts' 'Axel Rominger' 'Thomas Pyka'] Purpose High blood glucose (hBG) in patients undergoing [18F]FDG PET/CT scans often results in rescheduling the examination, which may lead to clinical delay for the patient and decrease productivity for the department. The…
Helen Goeden
In 2007, the Minnesota Department of Health (MDH) developed new risk assessment methods for deriving human health-based water guidance (HBG) that incorporated the assessment of multiple exposure durations and life stages. The methodology is based on US Environmental Protection Agency recommendations for protecting…
Tobias M. Franks, Sharie J. Haugabook, Elizabeth A. Ottinger, Meghan S. Vermillion + 3 more
Mouse models of sickle cell disease (SCD) that faithfully switch from fetal to adult hemoglobin (Hb) have been important research tools that accelerated advancement towards treatments and cures for SCD. Red blood cells (RBCs) in these animals sickled in vivo, occluded small vessels in many organs and resulted in severe…
Lihua Chen, Chunfeng Cui, Zhiheng Wang, Fuhong Che + 3 more
In order to efficiently extract β-glucan from highland barley (HBG) and study its structural characterization and antioxidant activity, ultrasonic-microwave-assisted extraction (UME) was optimized by the response surface method (RSM). Under the optimal extraction conditions of 25.05 mL/g liquid-solid ratio, 20 min…
Daniel Deluiz, Gaëtan J.-R. Delcroix, Samira R. G. Fraga, Gianluca D’Ippolito + 6 more
'Gianluca D’Ippolito' 'Cristina Grau-Monge' 'Andrea Bonnin-Marquez' 'Teresita Reiner' 'Thaís Amadeu' 'Eduardo M. B. Tinoco' 'Paul Christian Schiller'] Lack of bone volume to place dental implants is frequently a problem in the reconstruction of edentulous patients. Even though autografts are the gold standard for jaw…
Takako Inoue, Yasuhito Tanaka
update Hepatitis B virus and its sexually transmitted infection Authors: ['Takako Inoue' 'Yasuhito Tanaka'] Epidemiology: incidence and prevalence: About 5% of the world’s population has chronic hepatitis B virus (HBV) infection, and nearly 25% of carriers develop chronic hepatitis, cirrhosis, and hepatocellular…
Narges Soozangar, Ehsan Abbaspour, Haleh Mokaber, Zahra Nematollahi + 1 more
A 30-year-old male couple from Ardabil city, Iran, were admitted for premarital screening. An abnormal band in HbS/D regions with high levels of HbF and HbA 2 led us to suspect the possibility of a compound heterozygous state of β-thalassemia in our affected proband. Therefore, beta globin chain sequencing of proband…
Feng Yuan, Wei Wong
A new bioink consisted of single-walled carbon nanotubes (SWCNTs) conjugated with anti-HBsAg antibodies (SWCNT-Ab) was applied for the detection of HBsAg. The electrical conductivity of the printed film was optimized by printing multiple layers of the SWCNT-Ab bioink. The biosensors showed a linear response range from…
Tshifhiwa Magoro, George Gachara, Lufuno Mavhandu, Emmaculate Lum + 3 more
'Helen K. Kimbi' 'Roland N. Ndip' 'Pascal Bessong'] Background HBV and HIV share similar transmission routes. Concurrent infection with the two viruses usually results in more severe and progressive liver disease, and a higher incidence of cirrhosis, liver cancer and mortality. Further, this co-infection may lead to…
Authors not listed
Hexagonal boron nitride (hBN) is a two-dimensional material isoelectric to graphene. It has a hexagonal structure with alternating boron and nitrogen atoms and is electrically insulating, thermally conductive, and chemically inert. However, like graphene, its use as a functional nanofiller requires exfoliation. Here…
J. Coutinho, Diana Gomes, V. J. B. Torres, Tarek O. Abdul Fattah + 2 more
'В. П. Маркевич' 'А. R. Peaker'] The thermodynamics of several reactions involving atomic and molecular hydrogen with group-III acceptors is investigated. The results provide a first-principles-level account of thermally- and carrier-activated processes involving these species. Acceptor-hydrogen pairing is revisited as…
Abdelrahman Hussein, Byungki Kim, Kim Verbeken, Tom Depover
Understanding hydrogen-grain boundary (GB) interactions is critical to the analysis of hydrogen embrittlement in metals. This work presents a mesoscale fully kinetic model to investigate the effect of GB misorientation on hydrogen diffusion and trapping using phase-field based representative volume elements (RVEs). The…
Agnieszka Kuc, Yun An, Petko Petkov, Marcelo Lozada-Hidalgo + 1 more
Recent experiments have demonstrated transport and separation of hydrogen isotopes in layered materials, such as hexagonal boron nitride and molybdenum disulphide. Here, based on first-principles calculations combined with well-tempered metadynamics simulations, we report the chemical interactions and mobility of…
Ankoor Patel, Zahra Dossaji, Kapil Gupta, Katerina Roma + 5 more
'Toni-Marie Chandler' 'Carlos D. Minacapelli' 'Kaitlyn Catalano' 'Robert Gish' 'Vinod Rustgi'] The epidemiology of Hepatitis B virus (HBV) has drastically changed in recent decades due to public health initiatives, including universal infant vaccination programs,urbanization driving global travel, and migration…
Mariam Cherri, Paraskevi S. Stergiou, Zainab Ahmadian, Tatyana L. Povolotsky + 4 more
Infectious wounds occur when harmful microorganisms such as bacteria or viruses invade a wound site. Its problems associated include delayed healing, increased pain, swelling, and the potential for systemic infections. Therefore, developing new wound dressing materials with antibacterial effects is crucial for…
Katrin Ackermann, Siavash Khazaipoul, Joshua Wort, Amélie Sobczak + 3 more
Mammalian histidine-rich glycoprotein (HRG) is a highly versatile and abundant blood plasma glycoprotein with a diverse range of ligands that is involved in regulating many essential biological processes, including coagulation, cell adhesion and angiogenesis. Despite its biomedical importance, structural information on…
J. Coutinho, Diana Gomes, V. J. B. Torres, Tarek O. Abdul Fattah + 2 more
'В. П. Маркевич' 'А. R. Peaker'] We present a theoretical account of some of the most likely hydrogen-related reactions with impurities in n-type and p-type solar-grade silicon. These include reactions with dopants and carbon, which are relevant in the context of life-time degradation of silicon solar cells, most…
Authors not listed
Helicobacter pylori adhesin A (HpaA) is a surface-associated protein critical for the adhesion of H. pylori to gastric epithelial cells, which is strongly associated with an increased risk of gastric cancer. Recent elucidation of the 3D structure of HpaA offers novel opportunities for targeted therapeutic strategies to…
Xiaohan Bie, Jun Song
High strength steels (HSS) are widely used in aerospace industries but they can be susceptible to hydrogen embrittlement (HE), a phenomenon that with the ingress of a small amount of hydrogen, the materials can experience a ductile to brittle transition. Secondary carbide precipitates play a crucial role in reducing HE…