20 papers · ranked by Valyu relevance
Cara S. Kosack, Leslie Shanks, Greet Beelaert, Tumwesigye Benson + 6 more
'Aboubacar Savane' 'Anne Ng’ang’a' 'Bita Andre' 'Jean-Paul BN Zahinda' 'Katrien Fransen' 'Anne-Laure Page'] Title: Abstract Introduction: We evaluated the diagnostic accuracy of HIV testing algorithms at six programmes in five sub-Saharan African countries. Methods: In this prospective multisite diagnostic evaluation…
Hetal K. Patel, Yen T. Duong, Sehin Birhanu, Melissa Metz + 12 more
Population-based HIV Impact Assessment surveys were conducted in 14 countries to measure HIV prevalence, incidence, and viral load suppression in children aged 0-14 years and adults aged ≥15 years. We examined the performance of rapid HIV testing algorithms in multiple countries. Survey participants received an HIV…
NKOANE, Tapologo, QUTIESHAT, Abubaker
The limitation of this study is the small sample size of papers dealing with the subject; similar studies may need to be conducted in future as more literature becomes available. Additionally, there was less data available from sub-Saharan Africa as most of the reviewed articles were from more developed countries with…
Pontiano Kaleebu, Paul Kato Kitandwe, Tom Lutalo, Aminah Kigozi + 7 more
'Christine Watera' 'Mary Bridget Nanteza' 'Peter Hughes' 'Joshua Musinguzi' 'Alex Opio' 'Robert Downing' 'Edward Katongole Mbidde'] Introduction The World Health Organization recommends that countries conduct two phase evaluations of HIV rapid tests (RTs) in order to come up with the best algorithms. In this report, we…
Jörg Schüpbach, Leslie R Bisset, Stephan Regenass, Philippe Bürgisser + 10 more
'Philippe Bürgisser' 'Meri Gorgievski' 'Ingrid Steffen' 'Corinne Andreutti' 'Gladys Martinetti' 'Cyril Shah' 'Sabine Yerly' 'Thomas Klimkait' 'Martin Gebhardt' 'Franziska Schöni-Affolter' 'Martin Rickenbach'] Background Serologic testing algorithms for recent HIV seroconversion (STARHS) provide important information…
Ian E. Fellows, Wolfgang Hladik, Jeffrey W. Eaton, Andrew C. Voetsch + 2 more
'Bharat Parekh' 'Ray W. Shiraishi'] Estimating HIV-1 incidence using biomarker assays in cross-sectional surveys is important for understanding the HIV pandemic. However, the utility of these estimates has been limited by uncertainty about what input parameters to use for False Recency Rate (FRR) and Mean Duration of…
Makiko Kondo, Koji Sudo, Takako Sano, Takuya Kawahata + 9 more
Accurate diagnosis of earlier HIV infection is essential for treatment and prevention. Currently, confirmation tests of HIV infection in Japan are performed using Western blot (WB), but WB has several limitations including low sensitivity and cross-reactivity between HIV-1 and HIV-2 antibodies. To address these…
Éric Brier, Megi Dervishi, Rémi Géraud, David Naccache + 1 more
'Ofer Yifrach-Stav'] In this paper we discuss testing strategies that provably approach bestpossible strategy — optimal in the sense that no other strategy can give exact results with fewer tests. Our algorithms guarantee that they provide a complete and exact result for every individual, without exceeding 1/0.99 times…
Akseli Kangaslahti, Davin Choo, Lingkai Kong, Milind Tambe + 2 more
HIV is a retrovirus that attacks the human immune system and can lead to death without proper treatment. In collaboration with the WHO and Wits University, we study how to improve the efficiency of HIV testing with the goal of eventual deployment, directly supporting progress toward UN Sustainable Development Goal 3.3…
Kelly A. Curtis, Donna L. Rudolph, Yi Pan, Kevin Delaney + 12 more
Given the challenges and costs associated with implementing HIV-1 incidence assay testing, there is great interest in evaluating the use of commercial HIV diagnostic tests for determining recent HIV infection. A diagnostic test with the capability of providing reliable data for the determination of recent HIV infection…
Elizabeth A. Phillips, Taylor J. Moehling, Karin F.K. Ejendal, Orlando S. Hoilett + 7 more
Early Human Immunodeficiency Virus (HIV) testing is critical to preventing transmission and providing treatment to HIV-positive individuals, yet an estimated 30% of HIV-positive individuals do not know their status because of barriers to early diagnosis. Readily accessible, highly sensitive, and rapid diagnostic tests…
Jasper C Ho, Garway T Ng, Mathias Renaud, Art FY Poon
Genotypic resistance interpretation systems for the prediction and interpretation of HIV-1 antiretroviral resistance are an important part of the clinical management of HIV-1 infection. Current interpretation systems are generally hosted on remote webservers that enable clinical laboratories to generate resistance…
Eduard Grebe, Alex Welte, Jake Hall, Sheila M. Keating + 9 more
Custom staging assays, including the Sedia HIV-1 Limiting Antigen Avidity EIA (LAg) and avidity modifications of the Ortho VITROS anti-HIV-1+2 and Abbott ARCHITECT HIV Ag/Ab Combo assays, are used to identify ‘recent’ infections in clinical settings and for cross-sectional HIV incidence estimation. However, the high…
Noor Mohammad, Anastasiia Steksova, Yuyang Tang, Leyao Huang + 7 more
Human Immunodeficiency Virus-1 (HIV) remains a major global public health challenge, having led to over 42.3 million deaths since its discovery in the early 1980s. Despite progress in prevention and treatment, around 60% of people with HIV (PWH) remain undiagnosed in resource-limited regions, disproportionately…
Tieu-Long Phan, Hoang-Son Lai Le, Gia-Bao Truong, The-Chuong Trinh + 4 more
HIV-1 (Human immunodeficiency virus-1) has been causing severe pandemics by attacking the immune system of its host. Left untreated, it can lead to AIDS (acquired immunodeficiency syndrome), where death is inevitable due to opportunistic diseases. Therefore, discovering new antiviral drugs against HIV-1 is crucial.…
Matthew Aldridge, David Ellis
When testing for a disease such as COVID-19, the standard method is individual testing: we take a sample from each individual and test these samples separately. An alternative is pooled testing (or 'group testing'), where samples are mixed together in different pools, and those pooled samples are tested. When the…
Mustafa Arif, Gaurav Sharma
HIV (human immunodeficiency virus) is a virus that attacks the immune system, which serves as the body’s defense mechanism. If untreated, HIV can lead to AIDS (acquired immunodeficiency syndrome), which raises risk for a host of problems, especially infections and cancers. According to data from 2022, there are 39…
Émilien Joly, Bastien Mallein
The original problem of group testing consists in the identification of defective items in a collection, by applying tests on groups of items that detect the presence of at least one defective item in the group. The aim is then to identify all defective items of the collection with as few tests as possible. This…
Sanghyuk Ko
Different types of diagnostics methods were introduced to the public due to the recent global pandemic. From the real-time reverse transcript polymerase chain reaction (RT-qPCR) to antigen lateral flow assay (LFA), these tests allow relatively accurate and rapid diagnosis of the infection with SARS-CoV-2 virus. Because…
Marc Beunardeau, Éric Brier, Noémie Cartier, Aisling Connolly + 4 more
'Nathanaël Courant' 'Rémi Géraud' 'David Naccache' 'Ofer Yifrach-Stav'] Governments have taken several measures to work around this shortage: the FDA has become more liberal on the approval of COVID-19 tests in the US. In the UK emergency measures allowed to increase the daily number of locally produced test kits to…