16 papers · ranked by Valyu relevance
Salman Niazi, Mahmoud Ismail, Seif Haridi, Jim Dowling
Recent improvements in both the performance and scalability of shared-nothing, transactional, in-memory NewSQL databases have reopened the research question of whether distributed metadata for hierarchical file systems can be managed using commodity databases. In this paper, we introduce HopsFS, a next generation…
Corina-Aurelia Zugravu, Roxana-Elena Bohiltea, Teodor Salmen, Elena Pogurschi + 3 more
'Elena Pogurschi' 'Marina Ruxandra Otelea' 'Joanna Oracz' 'Dorota Żyżelewicz'] Hop plant (Humulus lupulus L.) has been used by humans for ages, presumably first as a herbal remedy, then in the manufacturing of different products, from which beer is the most largely consumed. Female hops cones have different useful…
Bartłomiej Piasecki, Anna Biernasiuk, Agnieszka Ludwiczuk, Daniela De Vita + 1 more
'Daniela De Vita' 'Marianna Carbone'] This study examined the chemical composition and anti-coccal properties of essential oils and methanolic extracts of six different Humulus lupulus L. varieties from Poland: Iunga, Marynka, Sybilla, Magnum, Tradition and Chinook. The activity of an α-acid-enriched fraction of…
Aastha Sindhwani, Subhash B. Arya, Harmeet Kaur, Divya Jagga + 3 more
'Amit Tuli' 'Mahak Sharma' 'Isabelle Coppens'] Salmonella enterica serovar typhimurium extensively remodels the host late endocytic compartments to establish its vacuolar niche within the host cells conducive for its replication, also known as the Salmonella-containing vacuole (SCV). By maintaining a prolonged…
Marcin Rozalski, Bartlomiej Micota, Beata Sadowska, Anna Stochmal + 3 more
'Dariusz Jedrejek' 'Marzena Wieckowska-Szakiel' 'Barbara Rozalska'] New antimicrobial properties of products derived from Humulus lupulus L. such as antiadherent and antibiofilm activities were evaluated. The growth of gram-positive but not gram-negative bacteria was inhibited to different extents by these compounds.…
Stanley Makumire, Tawanda Zininga, Juha Vahokoski, Inari Kursula + 1 more
Plasmodium falciparum causes the most lethal form of malaria. The cooperation of heat shock protein (Hsp) 70 and 90 is important for folding of a select number of cellular proteins that are crucial for cyto-protection and development of the parasites. Hsp70 and Hsp90 are brought into a functional complex that allows…
Kaushik Bhattacharya, Lorenz Weidenauer, Tania Morán Luengo, Pablo C. Echeverría + 7 more
Hop/Stip1/Sti1 is thought to be essential as a co-chaperone to facilitate substrate transfer between the Hsp70 and Hsp90 molecular chaperones. Despite this proposed key function for protein folding and maturation, it is not essential in a number of eukaryotes and bacteria lack an ortholog. We set out to identify and to…
Nilanjan Gayen, Sahana Mitra, Somesh Roy, Atin K. Mandal
The stability and activity of CRAF kinase are stringently regulated by heat shock protein 90 (Hsp90). Hsp90-mediated client folding and maturation is governed by its co-chaperones, but their functionality in chaperoning CRAF/Raf1 kinase to accomplish signaling under physiological conditions remains poorly understood.…
Dmitry Shvarev, Jannis Schoppe, Caroline König, Angela Perz + 9 more
Lysosomes are of central importance in cellular recycling, nutrient signaling ^1,2^ and endocytosis, and are tightly connected to autophagy ^3^ and the invasion of pathogenic bacteria and viruses ^1,4^. Lysosomal fusion events are fundamental to cell survival and require HOPS, a conserved heterohexameric tethering…
Silvia Di Lodovico, Luigi Menghini, Claudio Ferrante, Erica Recchia + 4 more
Bacteria belonging to Staphylococcus genus, in particular methicillin-resistant Staphylococcus aureus and multidrug-resistant Staphylococcus epidermidis, together with Cutibacterium acnes are the main strains involved in skin disease. The increase in multidrug-resistant bacteria has revived attention on natural…
Authors not listed
Biomass from crop residues is an abundant feedstock for biorefining through both chemical or biological processes. After breaking down intact biomass through physical or chemical means, the resulting pretreatment product contains a wide variety of small molecules that can be funneled into engineered microbes that…
Diego Bonatto
Diego Bonatto Centro de Biotecnologia da UFRGS - Lab. 212 Departamento de Biologia Molecular e Biotecnologia Universidade Federal do Rio Grande do Sul – UFRGS Avenida Bento Gonçalves 9500 - Prédio 43431 Caixa Postal 15005 Porto Alegre – Rio Grande do Sul BRAZIL 91509-900 Phone: (+55 51) 3308-9410 E-mail…
Zala Kolenc, Tomaž Langerholc, Gregor Hostnik, Miha Ocvirk + 8 more
'Sara Štumpf' 'Maša Pintarič' 'Iztok Jože Košir' 'Andreja Čerenak' 'Alenka Garmut' 'Urban Bren' 'Laura Grațiela Vicaș' 'Mariana Eugenia Mureșan'] The antimicrobial activity of hop extracts obtained from different hop genotypes were investigated against Staphylococcus aureus and Lactobacillus acidophilus. In this study…
Toshiki Kijima, Thomas L. Prince, Megan L. Tigue, Kendrick H. Yim + 9 more
Heat shock factor 1 (HSF1) initiates a broad transcriptional response to proteotoxic stress while also mediating a cancer-specific transcriptional program. HSF1 is thought to be regulated by molecular chaperones, including Heat Shock Protein 90 (HSP90). HSP90 is proposed to sequester HSF1 in unstressed cells, but…
Authors not listed
Sulfonimidamides have emerged as attractive chemical motifs in drug discovery and as sulfonamide bioisosteres that can offer improved pharmacokinetic and physiochemical properties. Here we report a mild SuFEx reaction of sulfonimidoyl fluorides using HOBt as a nucleophilic catalyst that is applicable to automated array…
Alberto N. Escalante-B., Laurenz Wiskott
Slow feature analysis (SFA) is an unsupervised-learning algorithm that extracts slowly varying features from a multi-dimensional time series. A supervised extension to SFA for classification and regression is graph-based SFA (GSFA). GSFA is based on the preservation of similarities, which are specified by a graph…