15 papers · ranked by Valyu relevance
Florian Wagner
The minimum hypergeometric test (mHG) is a powerful nonparametric hypothesis test to detect enrichment in ranked binary lists. Here, I provide a detailed review of its definition, as well as the algorithms used in its implementation, which enable the efficient computation of an exact pvalue. I then introduce a…
Claudia P. Cabrera, Pau Navarro, Jennifer E. Huffman, Alan F. Wright + 7 more
'Caroline Hayward' 'Harry Campbell' 'James F. Wilson' 'Igor Rudan' 'Nicholas D. Hastie' 'Veronique Vitart' 'Chris S. Haley'] Genome-wide association studies (GWAS) aim to detect single nucleotide polymorphisms (SNP) associated with trait variation. However, due to the large number of tests, standard analysis techniques…
Dmitriy G. Seleznev, Alexander A. Prokin, Ekaterina M. Kurina
A methodology for identifying pairs of mutually associated and mutually incompatible species pairs based on qualitative ecological data in the ‘species-samples’ format is described. Statistical criteria for assessing the direction and strength of species associations using discrete hypergeometric and binomial…
Vasileios Stathias, Chiara Pastori, Tess Z. Griffin, Ricardo Komotar + 4 more
'Jennifer Clarke' 'Ming Zhang' 'Nagi G. Ayad' 'Xia Li'] Patient specific therapy is emerging as an important possibility for many cancer patients. However, to identify such therapies it is essential to determine the genomic and transcriptional alterations present in one tumor relative to control samples. This presents…
Rui Fan, Qinghua Cui
Gene functional enrichment analysis represents one of the most popular bioinformatics methods for annotating the pathways and function categories of a given gene list. Current algorithms for enrichment computation such as Fisher’s exact test and hypergeometric test totally depend on the category count numbers of the…
Shuhei Mano
A distribution whose normalization constant is an A-hypergeometric polynomial is called an A-hypergeometric distribution. Such a distribution is in turn a generalization of the generalized hypergeometric distribution on the contingency tables with fixed marginal sums. In this paper, we will see that an A-hypergeometric…
Alexandre Wendling, Clovis Galiez
The analysis of binary outcomes and features, such as the effect of vaccination on health, often rely on 2 × 2 contingency tables. However, confounding factors such as age or gender call for stratified analysis, by creating sub-tables, which is common in bioscience, epidemiological, and social research, as well as in…
Hannes Schenk, Yasemin Caf, Ludwig Knabl, Christoph Mayerhofer + 1 more
'Wolfgang Rauch'] Demand for mass surveillance during peak times of the SARS-CoV-2 pandemic caused high workload for clinical laboratories. Efficient and cost conserving testing designs by means of group testing can substantially reduce resources during possible future emergency situations. The novel hypercube…
Héctor Francisco Coronel-Brizio, Alejandro Raúl Hernández-Montoya, Manuel Enrique Rodríguez-Achach, Horacio Tapia-McClung + 2 more
'Manuel Enrique Rodríguez-Achach' 'Horacio Tapia-McClung' 'Juan Evangelista Trinidad-Segovia' 'Ahmed M. Gemeay'] This paper introduces two new goodness-of-fit tests for the geometric distribution based on discrete adaptations of the Watson W2 and Anderson-Darling A2 statistics, where the probability of success is…
Rasmus Erlemann, Bo Henry Lindqvist
In this paper, we address the problem of testing goodness-of-fit for discrete distributions, where we focus on the geometric distribution. We define new likelihoodbased goodness-of-fit tests using the beta-geometric distribution and the type I discrete Weibull distribution as alternative distributions. The tests are…
Md Rejuan Haque, Laura Kubatko
Combination tests are used to combine P-values from individual studies to test a global null hypothesis. These types of tests can also be applied to combine P-values from testing separate null hypotheses within the same study in cases for which the procedure for testing a global null hypothesis is unavailable. One such…
Bruno Ebner, Norbert Henze, Simos G. Meintanis
> Abstract: We propose a general and relatively simple method for the construction of goodness-of-fit tests on the sphere and the hypersphere. The method is based on the characterization of probability distributions via their characteristic function, and it leads to test criteria that are convenient regarding…
Tiefeng Jiang, Tuan D. Pham
We propose a new probabilistic characterization of the uniform distribution on hyperspheres in terms of its inner product, extending the ideas of [12, [13]] in a data-driven manner. Using this characterization, we define a new distance that quantifies the deviation of an arbitrary distribution from uniformity. As an…
Mehmet Aziz Yirik, Maria Sorokina, Christoph Steinbeck
The generation of constitutional isomer chemical spaces has been a subject of cheminformatics since the early 1960s, with applications in structure elucidation and elsewhere. In order to perform such a generation efficiently, exhaustively and isomorphism-free, the structure generator needs to ensure the building of…
Niklas Hohmann
In this paper, a test for hypotheses on population dynamics is presented alongside an implementation of said test for R. The test is based on the assumption that the sample, consisting of points on a time axis, is a realization of a Poisson point process (PPP). There are no restrictions on the shapes of the rate…