19 papers · ranked by Valyu relevance
Eun Suk Song, Camila Camacho-Navas, Anwesha Goswami, Anmol Nayak + 6 more
Insulin-degrading enzyme (IDE, insulysin, insulinase) is a peptidase that hydrolyzes a number of bioactive peptides including insulin and the amyloid beta peptide, making it a promising therapeutic target for diabetes and Alzheimer’s disease. Aspects of its physiological role are still controversial, however. In an…
Karol, Daniil, Artser, Elizaveta + 8 more
Collecting data of students solving programming tasks is incredibly valuable for researchers and educators. It allows verifying that the students correctly apply the features and concepts they are taught, or finding students' misconceptions. However, existing data collection tools have limitations, e.g., no control…
Sarawoot Somin, Don Kulasiri, Sandhya Samarasinghe
The insulin-degrading enzyme (IDE) plays a significant role in the degradation of the amyloid beta (Aβ), a peptide found in the brain regions of the patients with early Alzheimer’s disease. Adenosine triphosphate (ATP) allosterically regulates the Aβ-degrading activity of IDE. The present study investigates the…
Elena Lyulina, Anastasiia Birillo, Vladimir Kovalenko, Timofey Bryksin
'Timofey Bryksin'] The process of writing code and use of features in an integrated development environment (IDE) is a fruitful source of data in computing education research. Existing studies use records of students' actions in the IDE, consecutive code snapshots, compilation events, and others, to gain deep insight…
Basha, Manaal, Ribeiro, Aimeê M. + 6 more
—Understanding how developers interact with code generation tools (CGTs) requires detailed, real-time data on programming behavior which is often difficult to collect without disrupting workflow. We present CodeWatcher, a lightweight, unobtrusive client-server system designed to capture fine-grained interaction events…
Grazia Raffaella Tundo, Diego Sbardella, Francesco Oddone, Giuseppe Grasso + 13 more
Carfilzomib is a last generation proteasome inhibitor (PI) with proven clinical efficacy in the treatment of relapsed/refractory multiple myeloma. This drug is considered to be extremely specific in inhibiting the chymotrypsin-like activity of the 20S proteasome, encoded by the β5 subunit, overcoming some bortezomib…
Philipp Eichmann, Carsten Binnig, Tim Kraska, Emanuel Zgraggen
Existing benchmarks for analytical database systems such as TPC-DS and TPC-H are designed for static reporting scenarios. The main metric of these benchmarks is the performance of running individual SQL queries over a synthetic database. In this paper, we argue that such benchmarks are not suitable for evaluating…
Angela Carrera-Rivera, Daniel Reguera-Bakhache, Felix Larrinaga, Ganix Lasa + 1 more
'Ganix Lasa' 'Iñaki Garitano'] This article introduces a dataset of human-machine interactions collected in a controlled and structured manner. The aim of this dataset is to provide insights into user behavior and support the development of adaptive Human-Machine Interfaces (HMIs). The dataset was generated using a…
Coralie Muller, Beatriz Serrano-Solano, Yi Sun, Christian Tischer + 1 more
Many bioimage analysis projects produce quantitative descriptors of regions of interest in images. Associating these descriptors with visual characteristics of the objects they describe is a key step in understanding the data at hand. However, as many bioimage data and their analysis workflows are moving to the cloud…
Hannah Catabia, Caren Smith, José Ordovás
Interactome analysis is an increasingly useful tool for discovering disease pathways. However, protein interaction data is scattered among different sources, and researchers must often sift through several large repositories before beginning a project. Inter-Tools allows users to search databases in the PSI-MITAB…
RT Pillich, J Chen, C Churas, D Fong + 7 more
The investigation of sets of genes using biological pathways is a common task for researchers and is supported by a wide variety of software tools. This type of analysis generates hypotheses about the biological processes active or modulated in a specific experimental context. The NDEx Integrated Query (IQuery) is a…
April Kim, Edyta Malolepsza, Justin Lim, Kasper Lage
Integrating protein-protein interaction experiments and genetic datasets can lead to new insight into the cellular processes implicated in diseases, but this integration is technically challenging. Here, we describe Genoppi, a web application that integrates quantitative interaction proteomics data and results from…
Luiza Wasiewska, Fernando Diaz, Han Shao, Catherine Burgess + 2 more
Shiga toxin-producing E. coli (STEC) is a food-borne pathogen of significant concern due to the severity of the disease it can cause. Herein we report the development of a highly sensitive, label-free, electrochemical DNA-based sensor for detection of stx1 gene using interdigitated gold microelectrodes (IDEs) on fully…
Qi Zhao, Yubin Xie, Peng Nie, Rucheng Diao + 3 more
Differential expression (DE) analysis is a fundamental task in the downstream analysis of the next-generation sequencing (NGS) data. Up to now, a number of R packages have been developed for detecting differentially expressed genes. Although R language has an interaction-oriented programming design, for many biology…
Ingmar Dasseville, Gerda Janssens
IDP is a knowledge base system based on first order logic. It is finding its way to a larger public but is still facing practical challenges. Adoption of new languages requires a newcomer-friendly way for users to interact with it. Both an online presence to try to convince potential users to download the system and…
Carlos Alberto Fernández y Fernández, José Angel Quintanar Morales
Quality assurance is an activity embedded in the entire process of software engineering, covering aspects such as: methods and tools of analysis, design, coding, testing and formal technical reviews, control of software documentation and changes made, and a monitoring procedure to ensure the software development…
Authors not listed
A multiplexed, highly sensitive, and stable electrochemical sensors has been developed for the detection of glucose and lactate in biological fluids, enabling early screening of calf diseases such as Bovine respiratory disease (BRD) and scour. The device incorporates an interdigitated microelectrode (IDE) array…
Ying Zhang, Karsten Klein, Falk Schreiber, Kamran Safi
More diverse data on animal ecology are now available. This “data deluge” presents challenges for both biologists and computer scientists; however, it also creates opportunities to improve analysis and answer more holistic research questions. We aim to increase awareness of the current opportunity for interdisciplinary…
Christina Humer, Rachel Nicholls, Henry Heberle, Moritz Heckmann + 7 more
Chemical reaction optimization (RO) is an iterative process that results in large and high-dimensional datasets. Current tools only allow for limited analysis and understanding of parameter spaces, making it hard for scientists to review or follow changes throughout the process. With the recent emergence of using…