24 papers · ranked by Valyu relevance
Naoe Kaneko, Mie Kurata, Toshihiro Yamamoto, Shinnosuke Morikawa + 1 more
'Junya Masumoto'] Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological functions and pathological significances and play an important role in health and disease. In this decade, interleukin-1 family members have been expanding and evidence is accumulating that highlights the importance…
Rebekka Bent, Lorna Moll, Stephan Grabbe, Matthias Bros
Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. This review aims to summarize current knowledge about parameters of regulation of IL-1β expression and…
Elena Voronov, Yaron Carmi, Ron N. Apte
Tumor angiogenesis is one of the hallmarks of tumor progression and is essential for invasiveness and metastasis. Myeloid inflammatory cells, such as immature myeloid precursor cells, also termed myeloid-derived suppressor cells (MDSCs), neutrophils, and monocytes/macrophages, are recruited to the tumor…
Cecilia Garlanda, Irene Di Ceglie, Sebastien Jaillon
Interleukin-1 (IL-1) was the first interleukin identified as a potent proinflammatory and multifunctional molecule involved in innate immune responses against microbes, as well as in conditions of tissue injury associated with infections and sterile conditions. IL-1 is part of a large system, the IL-1 system…
Jinyi Zhao, Zhu Liang, Benedikt M Kessler, Liye Chen
Interleukin-1 beta (IL-1β) is known as an inflammasome-dependent pro-inflammatory cytokine that has been implicated in T-cell-driven autoimmune diseases. In mice, T-cells were reported to instruct myeloid cells to produce IL-1β via an inflammasome-independent mechanism, that engages TNFR and Fas-caspase-8-dependent…
Luqiu Mou, Conggang Zhang
Interleukin-1β (IL-1β) is an essential pro-inflammatory cytokine which functions as a key factor in innate immunity. The precursor protein, pro-IL-1β, has long been regarded as an inactive form in innate immune responses. Here, we unveil the biological function and regulation of pro-IL-1β in activating the NF-κB…
Vishwas Mishra, Anna Crespo-Puig, Callum McCarthy, Tereza Masonou + 9 more
The cytokine interleukin-1β (IL-1β) has pivotal roles in antimicrobial immunity, but also incites inflammatory pathology. Bioactive IL-1β is released following proteolytic maturation of the pro-IL-1β precursor by caspase-1 inflammasomes. UBE2L3/UBCH7, a conserved ubiquitin conjugating enzyme, promotes pro-IL-1β…
Ting-ting Liu, Yan-kun Chen, Muhammad Adil, Mazen Almehmadi + 7 more
'Fahad M. Alshabrmi' 'Mamdouh Allahyani' 'Ahad Amer Alsaiari' 'Pei Liu' 'Muhammad Raheel Khan' 'Qinghua Peng' 'Joel D. A. Tyndall'] IL-1β mediates inflammation and regulates immune responses, cell proliferation, and differentiation. Dysregulation of IL-1β is linked to inflammatory and autoimmune diseases. Elevated…
Matteo Trimarchi, Dorina Lauritano, Gianpaolo Ronconi, Alessandro Caraffa + 6 more
'Alessandro Caraffa' 'Carla E. Gallenga' 'Ilias Frydas' 'Spyros K. Kritas' 'Vittorio Calvisi' 'Pio Conti' 'Christian Morsczeck'] Much evidence suggests autoimmunity in the etiopathogenesis of periodontal disease. In fact, in periodontitis, there is antibody production against collagen, DNA, and IgG, as well as…
Tatiane S. Lima
Since its discovery in the early 1940s, the interleukin-1 (IL-1) cytokine family has been associated primarily with acute and chronic inflammation. The family member IL-1β is produced by different leucocytes, endothelial cells and epithelial cells. This cytokine has been characterized as a key modulator of inflammation…
R.K. Subbarao Malireddi, Ratnakar Bynigeri, Balabhaskararao Kancharana, Bhesh Raj Sharma + 3 more
Interleukin 1α (IL-1α) and IL-1β are the founding members of the IL-1 cytokine family, and these innate immune inflammatory mediators are critically important in health and disease. Early studies on these molecules suggested that their expression was interdependent, with an initial genetic model of IL-1α depletion, the…
Eva Hasel de Carvalho, Eva Bartok, Helen Stölting, Baubak Bajoghli + 1 more
The cytokine Interleukin 1 (IL-1) is an evolutionary innovation of vertebrates. Fish and amphibia have one IL1 gene, while mammals have two copies of IL1, IL1A and IL1B, with distinct expression patterns and differences in their proteolytic activation. Our current understanding of the evolutionary history of IL-1 is…
Yan, Xianyi, Xi Wang, Ying Che + 2 more
- 1 Department of Orthopaedic, The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, 528200 Foshan,Guangdong, China; lyyanxy@scut.edu.cn(X.Y.);zhangtin@pitt.edu (T.Z.) - 2 Department of Trauma Orthopedics, The First Affiliated Hospital of Xinjiang Medical University, 830011 Urumqi…
Emerson Krock, Alexandra Jurczak, Camilla I. Svensson
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by joint inflammation and joint pain. Much of RA treatment is focused on suppressing inflammation, with the idea being that if inflammation is controlled other symptoms, such as pain, will disappear. However, pain is the most common complaint of…
James K. Fields, Kyle Kihn, Gabriel S. Birkedal, Erik H. Klontz + 8 more
Interleukin-1 (IL-1) family cytokines are potent mediators of inflammation, acting to coordinate local and systemic immune responses to a wide range of stimuli. Aberrant signaling by IL-1 family cytokine members, however, is linked to myriad inflammatory syndromes, autoimmune conditions and cancers. As such, blocking…
Alberto Dinarello, Makenna May, Jesus Amo-Aparicio, Tania Azam + 11 more
The IL-1 Family member IL-38 has been characterized primarily as an anti-inflammatory cytokine in human and mouse models of systemic diseases. Here, we examined the role of IL-38 in the murine small intestine (SI). Immunostaining of SI revealed that IL-38 expression partially confines to intestinal stem cells. Cultures…
Andreas Kühnapfel, Katrin Horn, Ulrike Klotz, Michael Kiehntopf + 6 more
'Maciej Rosołowski' 'Markus Loeffler' 'Peter Ahnert' 'Norbert Suttorp' 'Martin Witzenrath' 'Markus Scholz'] Methods: For up to N=389 genotyped participants of the PROGRESS study of hospitalised CAP patients, we performed a genome-wide association study of ten cytokines IL-1β, IL-6, IL-8, IL-10, IL-12, MCP-1 (MCAF)…
She, Xutong
Alzheimer's disease (AD) persists as a paramount challenge in neurological research, characterized by the pathological hallmarks of amyloid-β (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau. This review synthesizes the evolving understanding of AD pathogenesis, moving beyond the linear…
Kristen A. Windoloski, Susanne Janum, Ronan M. G. Berg, Mette S. Olufsen
'Mette S. Olufsen'] 1 Department of Mathematics, North Carolina State University, Raleigh, North Carolina, USA Frederiksberg and Bispebjerg Hospitals, Frederiksberg, Denmark Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Denmark Centre for Physical Activity Research…
Fiona R. Macfarlane, Mark A. J. Chaplain, Raluca Eftimie
Rheumatoid arthritis is a chronic autoimmune disease that is a major public health challenge. The disease is characterised by inflammation of synovial joints and cartilage erosion, which lead to chronic pain, poor life quality and, in some cases, mortality. Understanding the biological mechanisms behind the progression…
Carley V. Cook, Ariel M. Lighty, Brenda J. Smith, Ashlee N. Ford Versypt
Bone remodeling is an essential physiological process in the adult skeleton. Due to the complex nature of this process, many mathematical models of bone remodeling have been developed. Each of these models has unique features, but they have underlying patterns. In this review, the authors highlight the important…
Authors not listed
Plasma proteomics has regained attention in recent years through advancements in mass spectrometry instrumentation and sample preparation, as well as new high-throughput affinity-based technologies. Here, we evaluate the analytical performance of the new Olink Reveal platform, a proximity extension assay (PEA)-based…
Rumiana Tenchov, Janet Sasso, Xinmei Wang, Qiongqiong Angela Zhou
Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Anti-aging research has a long history…
Kristen A. Windoloski, Elisabeth O. Bansgaard, A Dobréva, Johnny T. Ottesen + 1 more
'Johnny T. Ottesen' 'Mette S. Olufsen'] Abstract This study develops a unified model predicting the whole-body response to endotoxin. We simulate dynamics using differential equations examining the response to a lipopolysaccharide (LPS) injection. The model tracks pro- and antiinflammatory cytokines (TNF-, IL-6…