19 papers · ranked by Valyu relevance
Naoe Kaneko, Mie Kurata, Toshihiro Yamamoto, Shinnosuke Morikawa + 1 more
'Junya Masumoto'] Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological functions and pathological significances and play an important role in health and disease. In this decade, interleukin-1 family members have been expanding and evidence is accumulating that highlights the importance…
Rebekka Bent, Lorna Moll, Stephan Grabbe, Matthias Bros
Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. This review aims to summarize current knowledge about parameters of regulation of IL-1β expression and…
Giulio Cavalli, Charles A. Dinarello
Interleukin-1 (IL-1) is the prototypical inflammatory cytokine: two distinct ligands (IL-1α and IL-1β) bind the IL-1 type 1 receptor (IL-1R1) and induce a myriad of secondary inflammatory mediators, including prostaglandins, cytokines, and chemokines. IL-1α is constitutively present in endothelial and epithelial cells…
L. A. Borthwick
The IL-1 cytokine family comprises 11 members (7 ligands with agonist activity, 3 receptor antagonists and 1 anti-inflammatory cytokine) and is recognised as a key mediator of inflammation and fibrosis in multiple tissues including the lung. IL-1 targeted therapies have been successfully employed to treat a range of…
Elena Voronov, Yaron Carmi, Ron N. Apte
Tumor angiogenesis is one of the hallmarks of tumor progression and is essential for invasiveness and metastasis. Myeloid inflammatory cells, such as immature myeloid precursor cells, also termed myeloid-derived suppressor cells (MDSCs), neutrophils, and monocytes/macrophages, are recruited to the tumor…
Cecilia Garlanda, Irene Di Ceglie, Sebastien Jaillon
Interleukin-1 (IL-1) was the first interleukin identified as a potent proinflammatory and multifunctional molecule involved in innate immune responses against microbes, as well as in conditions of tissue injury associated with infections and sterile conditions. IL-1 is part of a large system, the IL-1 system…
Diana Boraschi
Interleukin-1 is a cytokine with potent inflammatory and immune-amplifying effects, mainly produced by macrophages during defensive reactions. In mammals, IL-1 is a superfamily of eleven structurally similar proteins, all involved in inflammation or its control, which mainly act through binding to specific receptors on…
Sven E. Niklander, Craig Murdoch, Keith D. Hunter
Decades ago, the study of cancer biology was mainly focused on the tumor itself, paying little attention to the tumor microenvironment (TME). Currently, it is well recognized that the TME plays a vital role in cancer development and progression, with emerging treatment strategies focusing on different components of the…
Ting-ting Liu, Yan-kun Chen, Muhammad Adil, Mazen Almehmadi + 7 more
'Fahad M. Alshabrmi' 'Mamdouh Allahyani' 'Ahad Amer Alsaiari' 'Pei Liu' 'Muhammad Raheel Khan' 'Qinghua Peng' 'Joel D. A. Tyndall'] IL-1β mediates inflammation and regulates immune responses, cell proliferation, and differentiation. Dysregulation of IL-1β is linked to inflammatory and autoimmune diseases. Elevated…
Gabriele Fenini, Emmanuel Contassot, Lars E. French
In 2002, intracellular protein complexes known as the inflammasomes were discovered and were shown to have a crucial role in the sensing of intracellular pathogen- and danger-associated molecular patterns (PAMPs and DAMPs). Activation of the inflammasomes results in the processing and subsequent secretion of the…
Jessica Millar, Elias Nasser, Gorav Ailawadi, Morgan Salmon
Abdominal Aortic Aneurysms (AAA) remain a clinically devastating disease with no effective medical treatment therapy. AAAs are characterized by immune cell infiltration, smooth muscle cell apoptosis, and extracellular matrix degradation. Interleukin-1 (IL-1) has been shown to play role in AAA associated inflammation…
Matteo Trimarchi, Dorina Lauritano, Gianpaolo Ronconi, Alessandro Caraffa + 6 more
'Alessandro Caraffa' 'Carla E. Gallenga' 'Ilias Frydas' 'Spyros K. Kritas' 'Vittorio Calvisi' 'Pio Conti' 'Christian Morsczeck'] Much evidence suggests autoimmunity in the etiopathogenesis of periodontal disease. In fact, in periodontitis, there is antibody production against collagen, DNA, and IgG, as well as…
Tatiane S. Lima
Since its discovery in the early 1940s, the interleukin-1 (IL-1) cytokine family has been associated primarily with acute and chronic inflammation. The family member IL-1β is produced by different leucocytes, endothelial cells and epithelial cells. This cytokine has been characterized as a key modulator of inflammation…
Hae-Ri Lee, Young-Jin Jeong, Joong-Woon Lee, JooYeon Jhun + 6 more
'Hyun Sik Na' 'Keun-Hyung Cho' 'Seok Jung Kim' 'Mi-La Cho' 'Tae-Hwe Heo' 'Hassan Zmerly'] Interleukin-1β (IL-1β) is one of the most potent pro-inflammatory cytokines implicated in a wide range of autoinflammatory, autoimmune, infectious, and degenerative diseases. Therefore, many researchers have focused on developing…
Sonia Carta, Rosa Lavieri, Anna Rubartelli
Intercellular communications control fundamental biological processes required for the survival of multicellular organisms. Secretory proteins are among the most important messengers in this network of information. Proteins destined to the extracellular environment contain a signal sequence with the necessary…
Authors not listed
炎症与感染会促进癌症的发生和发展。临床资料和流行病学研究显示，慢性感染与炎症和癌症之间存在较强的相关性。例如，长期酗酒会引发肝脏和胰脏的炎症，进而导致这些器官癌症的发生机率增加；长期吸烟和接触石棉、硅石都会导致肺部的感染，进而使发生肺癌的可能性增加。最新的基于人类肿瘤和鼠类肿瘤模型的研究结果表明，肿瘤微环境中的炎症反应是肿瘤发生与发展中的一个重要环节。将炎症与癌症联系起来的一个重要因素是活化的机体免疫细胞和癌细胞产生的细胞因子，它们可以促进肿瘤的生长和发展。巨噬细胞产生的白细胞介素-1β（interleukin-1β, IL -1β）可以引起炎症反应，还引起促炎基因的表达，如环氧化物酶-2（cyclooxygenase type…
Tom Macleod, Anna Berekmeri, Charlie Bridgewood, Martin Stacey + 2 more
'Dennis McGonagle' 'Miriam Wittmann'] The skin barrier would not function without IL-1 family members, but their physiological role in the immunological aspects of skin barrier function are often overlooked. This review summarises the role of IL-1 family cytokines (IL-1α, IL-1β, IL-1Ra, IL-18, IL-33, IL-36α, IL-36β…
Francesca Oliviero, Paolo Sfriso, Leonardo Punzi, Jean-Michel Dayer
Interleukin 1 (IL-1) is a crucial mediator of the inflammatory response, playing an important part in the body's natural responses and the development of acute pathological conditions leading to chronic inflammation and tissue destruction. In the last decades, specific IL-1-targeting therapies have produced beneficial…
Michael J. D. Daniels, David Brough, Gian-Pietro Di Sansebastiano, Antonio Gaballo
'Antonio Gaballo'] In the conventional pathway of protein secretion, leader sequence-containing proteins leave the cell following processing through the endoplasmic reticulum (ER) and Golgi body. However, leaderless proteins also enter the extracellular space through mechanisms collectively known as unconventional…