13 papers · ranked by Valyu relevance
Herbert Baier, Jörg Schultz
Background Information about genes, transcripts and proteins is spread over a wide variety of databases. Different tools have been developed using these databases to identify biological signals in gene lists from large scale analysis. Mostly, they search for enrichments of specific features. But, these tools do not…
Liudmila S. Mainzer, Brad A. Chapman, Oliver Hofmann, Gloria Rendon + 2 more
As the pace of implementing personalized medicine concepts increases, high-throughput variant calling on hundreds of individual genomes per day is a reality that will likely be faced by sequencing facilities across the country in the near future. While the scientific best practices for human variant calling workflows…
NVIDIA, :, Mittal, Mayank + 208 more
We present Isaac Lab, the natural successor to Isaac Gym, which extends the paradigm of GPU-native robotics simulation into the era of large-scale multi-modal learning. Isaac Lab combines high-fidelity GPU parallel physics, photorealistic rendering, and a modular, composable architecture for designing environments and…
Sicong Gao, Maurice Pagnucco, Tomasz Bednarz, Yang Song
Simulation has become a core infrastructure for robotics research. Unlike previous simulators, NVIDIA Isaac Sim leverages GPU acceleration to enable large-scale parallel training and physics-accurate modeling. Its synthetic data generation pipeline alleviates the scarcity of high-quality training data, supporting…
Caio C. D. Disserol, Mario T. Sato, Yago Alfaro, Hélio A. G. Teive
Sir Isaac Newton is widely regarded as one of the greatest scientific minds in history, with seminal contributions across mathematics, physics-particularly optics-and the formulation of the law of universal gravitation. Less well known, however, is his extraordinary and rarely recognized contribution to the field of…
Zhixiang Chen, Zhuangbin Chen, Ruoxi Jia, Zeqin Liao + 3 more
Robotics simulators serve as a foundational infrastructure for embodied AI, facilitating safe and scalable robotic system development. NVIDIA Isaac Sim has emerged as one of the most popular simulators, distinguished by its GPU-accelerated physics engine and photorealistic rendering, which enable high-fidelity modeling…
M Innes Asher, Alistair W Stewart, Javier Mallol, Stephen Montefort + 3 more
'Christopher KW Lai' 'Nadia Aït-Khaled' 'Joseph Odhiambo' ''] The International Study of Asthma and Allergies in Childhood (ISAAC) Phase One showed large worldwide variations in the prevalence of symptoms of asthma, rhinoconjunctivitis and eczema, up to 10 to 20 fold between countries. Ecological analyses were…
Alex J. Cornish, Daniel Chubb, Anna Frangou, Phuc H. Hoang + 3 more
Estimating the fraction of cancer cells with individual somatic mutations is central to many analyses in cancer genomics, including characterisation of clonal architecture and timing of mutational events. Estimation of these cancer cell fractions (CCFs) is contingent on unbiased assessment of the fraction of reads…
Alex J Cornish, Daniel Chubb, Anna Frangou, Phuc H Hoang + 4 more
To the Editor, The Isaac pipeline described in the Bioinformatics article ‘Isaac: ultra-fast whole-genome secondary analysis on Illumina sequencing platform’ () has been used in cancer sequencing studies (; ) and in the ongoing UK 100 000 Genomes Project (100KGP) (). Whilst Isaac has been benchmarked with respect to…
Qi Yi Ambrose Wong, Dingyu Cen, Jun Jie Lim, Jia Yi Karen Wong + 8 more
Background: Asthma is a chronic respiratory condition affecting 3,340 cases per 100,000 individuals globally. The significant global health burden of asthma necessitates the development and use of valid diagnostic tools for epidemiological purposes. Objective: This study evaluated the diagnostic accuracy of the…
Alejandro Jenkins
After Isaac Newton was knighted by Queen Anne in 1705 he adopted an unusual coat of arms: a pair of human tibiæ crossed on a black background, like a pirate flag without the skull. After some general reflections on Newton's monumental scientific achievements and on his enigmatic life, we investigate the story of his…
Bryan C. Daniels, William S. Ryu, Ilya Nemenman
The roundworm C. elegans exhibits robust escape behavior in response to rapidly rising temperature. The behavior lasts for a few seconds, shows history dependence, involves both sensory and motor systems, and is too complicated to model mechanistically using currently available knowledge. Instead we model the process…
Indhu-Shree Rajan-Babu, Junran Peng, Readman Chiu, Arezoo Mohajeri + 4 more
Short tandem repeat (STR) expansions cause several neurological and neuromuscular disorders. Screening for STR expansions in genome-wide (exome and genome) sequencing data can enable diagnosis, optimal clinical management/treatment, and accurate genetic counselling of patients with repeat expansion disorders. We…