21 papers · ranked by Valyu relevance
Gregory J. Baker, Sucheendra K. Palaniappan, Jodene K. Moore, Stephanie H. Davis + 2 more
Investigational and computational methods for the systematic exploration of global immune response are needed to gain a more integrated comprehension of disease and to explore the mechanisms of immunotherapy. Here were describe a modular and extensible framework for the acquisition, analysis, and visual display of…
Andreas Roller, Iakov I Davydov, Petra C Schwalie, Martha L Serrano-Serrano + 8 more
The immune status of a patient’s tumor microenvironment (TME) may guide therapeutic interventions with cancer immunotherapy and help identify potential resistance mechanisms. Currently, patients’ immune status is mostly classified based on CD8+ tumor-infiltrating lymphocytes. An unmet need exists for comparable and…
Zhenyu Yang, Jixin Li, Fengzhao Liu, Xiaohan Xiu + 7 more
'Zhigang Sun' 'Xinyu Zhu' 'Mengzhu Chen' 'Xihao Chen' 'Haohong Zheng' 'Dandan Guo'] The aim of this study was to elucidate the causal relationship between immunophenotypes and heart failure (HF) using bidirectional Mendelian randomization (MR) analysis. Summary-level data for HF and immunophenotypes were obtained from…
Shinji Izuka, Toshihiko Komai, Takahiro Itamiya, Mineto Ota + 7 more
'Saeko Yamada' 'Yasuo Nagafuchi' 'Hirofumi Shoda' 'Kosuke Matsuki' 'Kazuhiko Yamamoto' 'Tomohisa Okamura' 'Keishi Fujio'] Title: Abstract Objective To elucidate crucial immune cell subsets and associated immunological pathways by stratifying patients with immune-mediated diseases (IMDs) using immunophenotyping and…
Aline Knab, Caroline Giardina, Shane T. Grey, Ewa M. Goldys + 1 more
'Jared M. Campbell'] Title: ABSTRACT Immunophenotyping provides valuable prognostic and diagnostic information, but is technically complex and expensive. The assessment of autofluorescence is label-free and provides complex information on cell identity. However, research on its application to immunophenotyping has been…
DM Woods, AS Laino, A Winters, J Alexandre + 4 more
The reshaping of the immune landscape by nivolumab (NIVO) and ipilimumab (IPI) and its relation to patient outcomes is not well-described. We used high-parameter flow cytometry and a novel computational platform, CytoBrute, to define immunophenotypes of up to 15 markers to assess peripheral blood samples from…
Lucie Abeler-Dörner, Adam G. Laing, Anna Lorenc, Dmitry S. Ushakov + 54 more
By developing a high-density murine immunophenotyping platform compatible with high-throughput genetic screening, we have established profound contributions of genetics and structure to immune variation. Specifically, high-throughput phenotyping of 530 knockout mouse lines identified 140 monogenic “hits” (>25%), most…
Masato Ogishi, Rui Yang, Conor Gruber, Simon Pelham + 11 more
We describe the integration of multi-batch cytometry datasets (iMUBAC), a flexible, robust, and scalable computational framework for unsupervised cell-type identification across multiple batches of high-dimensional cytometry datasets. After overlaying cells from healthy controls across multiple batches, iMUBAC learns…
Yue Wang, Yusi Shen, Lina Tan, Liangbo Hu + 2 more
Background Emerging evidence indicates a significant link between various immune cell types and the development of heart valve disorders. Mitral valve prolapse (MVP) is a common condition that can lead to heart failure, arrhythmias, and even sudden death. Currently, the role of immune cells in MVP is not well…
Jingting Liu, Yawei Zhou, Yijun Dong, Wendi Wang + 2 more
'Jianying Pei'] Background Studies using observational epidemiology have indicated that inflammation and immunological dysregulation are important contributors to placental and renal failure, which ultimately results in maternal hypertension. The potential causal relationships between the immunophenotypes and…
Ariful Azad, Bartek Rajwa, Alex Pothen
Motivation: We investigate whether a template-based classification pipeline could be used to identify immunophenotypes in (and thereby classify) a heterogeneous disease with many subtypes. The disease we consider here is Acute Myeloid Leukemia, which is heterogeneous at the morphologic, cytogenetic and molecular…
Dmitry V. Tabakov, Anna A. Maznina, Ekaterina A. Astakhova, Anastasia E. Egorova + 12 more
'Anastasia E. Egorova' 'Elena N. Zakharova' 'Olga V. Glushkova' 'Ekaterina S. Petriaikina' 'Dmitry V. Svetlichnyy' 'Julia A. Krupinova' 'Viktor P. Bogdanov' 'Vladimir S. Yudin' 'Anton A. Keskinov' 'Sergey M. Yudin' 'Mary Woroncow' 'Veronika I. Skvortsova' 'Pavel Yu Volchkov'] Immune system plays a central role in the…
Mikaël Simard, Zhuoyan Shen, M. Hawkins, Charles‐Antoine Collins‐Fekete
histopathology Authors: ['Mikaël Simard' 'Zhuoyan Shen' 'M. Hawkins' 'Charles‐Antoine Collins‐Fekete'] With the advent of novel cancer treatment options such as immunotherapy, studying the tumour immune micro-environment is crucial to inform on prognosis and understand response to therapeutic agents. A key approach to…
Grazziela P. Figueredo, Uwe Aickelin
Although there are various types of cancer treatments, none of these currently take into account the effect of ageing of the immune system and hence altered responses to cancer. Recent studies have shown that in vitro stimulation of T cells can help in the treatment of patients. There are many factors that have to be…
Mario Gaimann, Maximilian Nguyen, Jonathan Desponds, Andreas Mayer
The adaptive immune system responds to pathogens by selecting clones of cells with specific receptors. While clonal selection in response to particular antigens has been studied in detail, it is unknown how a lifetime of exposures to many antigens collectively shape the immune repertoire. Here, through mathematical…
Charlotte Adams, Kris Laukens, Wout Bittremieux, Kurt Boonen
Immunopeptidomics is a key technology in the discovery of targets for immunotherapy and vaccine development. However, identifying immunopeptides remains challenging due to their non-tryptic nature, which results in distinct spectral characteristics. Moreover, the absence of strict digestion rules leads to extensive…
Susmita Roy, Biman Bagchi
Clinical studies have indicated that in malignant surveillances fluctuations in the population of certain effector T-cell repertoire become suppressed. Motivated by such observations and in an attempt to quantify adaptive human response to pathogens, we define an immune response function (IMRF) in terms of mean square…
Andrew Goetz, Laurence Morel, Purushottam Dixit
Impaired metabolism is recognized as an important contributor to pathogenicity of T cells in Systemic Lupus Erythematosus (SLE). Over the last two decades, we have acquired significant knowledge about the signaling and transcriptomic programs related to metabolic rewiring in healthy and SLE T cells. However, our…
Tajudeen Yahaya, Titilola Salisu
The possibility of targeting the causal genes along with the mechanisms of pathogenically complex diseases has led to numerous studies on the genetic etiology of some diseases. In particular, studies have added more genes to the list of type 1 diabetes mellitus (T1DM) suspect genes, necessitating an update for the…
Authors not listed
In many autoimmune pathologies, including Rheumatoid Arthritis (RA), only a small percentage of the total B cell population is autoreactive and sustain disease. Yet, current immunotherapy treatments often eliminate the entire B-cell population, leading to immune deficiency. We developed an approach to selectively…
Kavita Iyer, Julian Ivanov, Rumiana Tenchov, Krittika Ralhan + 4 more
Rapid and sustained growth in the field of immuno-oncology has resulted in expansion of available scientific literature. Gaining valuable insights and establishing deep and often hidden meaningful connections in such a large body of work is the need of the hour. In this report we summarize our findings from a novel…