19 papers · ranked by Valyu relevance
Ling Wu, Tobilola Akingbade, Peter T. Nelson, Shih-Hsiu J. Wang + 1 more
Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a neurodegenerative disease marked by TDP-43 proteinopathy, affecting approximately one-third of individuals aged 80 and above. LATE neuropathological change (LATE-NC) is characterized by the accumulation of phosphorylated TDP-43 preferentially in the…
A Kapasi, L Yu, SE Leurgans, EY Chen + 5 more
Accumulations of AD and LATE-NC both contribute to changes in hippocampal volume, possibly via distinct and/or overlapping mechanisms. Microglia-driven inflammation is a shared pathway associated with both AD and LATE-NC. However, the extent to which microglia inflammation is associated with hippocampal volume is less…
Allison M Neltner, Ryan K Shahidehpour, Megan E Hall, Xiaotong Ning + 8 more
The locus coeruleus (LC) is the source of norepinephrinergic innervation in the human brain. Locus coeruleus pathology has been linked to clinical conditions such as cognitive impairment and behavioral and psychiatric symptoms of dementia (BPSD). However, phosphorylated TDP-43 (pTDP-43) pathology in the LC has been…
Jarok Koo, Hyungjin Lee, Yunyeong Choi, Kyoungwon Baik + 1 more
Introduction Alzheimer’s disease (AD) is the leading cause of neurodegenerative dementia, and mixed neuropathological changes including Lewy body (LB-NC) and TDP-43 (LATE-NC) are commonly observed in patients with AD. We examined the baseline cross-sectional and longitudinal effects of these co-pathologies on cognitive…
Hancheng Min, Zhihui Zhu, Renè Vidal
Among many mysteries behind the success of deep networks lies the exceptional discriminative power of their learned representations as manifested by the intriguing Neural Collapse (NC) phenomenon, where simple feature structures emerge at the last layer of a trained neural network. Prior works on the theoretical…
Authors not listed
N-substituted anilines and their derivatives are versatile building blocks for synthesizing pharmaceutical molecules, natural products, and functional materials. Given the significant role of biarylamine motifs in modern chemistry, the development of a mild and easily manageable protocol is highly desirable in…
Jade Enright Hostetler, Fion Shiau, Xiaodong Zhang, Shiming Chen + 3 more
Long noncoding RNAs (lncRNAs) display pervasive expression and function in the developing nervous system. Temporal profiling of gene expression in the retina has demonstrated differential expression of lncRNAs throughout development; however, determinations of lncRNA function during retinal development remain limited.…
Jiayi Zhu, Jing Lin, Zelong Tian, Feng He + 1 more
Time-Sensitive Networking (TSN) is critical to deterministic communication in safety-critical domains, with formal verification such as Network Calculus (NC) serving as the cornerstone for schedulability guarantees. However, during automated configuration-space exploration, repeated schedulability analysis consumes…
Eike A Strathmann, Ilka Ratjen, Klara Willrodt, Janna Enderle + 11 more
In a large sample of 5865 participants from the general population, we assessed the association of NC with anthropometric traits, cardiometabolic risk factors, and self-reported cardiometabolic disease events. As expected, NC was highly correlated with age and BMI in both sexes. Furthermore, NC was associated with…
Authors not listed
A water-free ionothermal synthesis of porous magnesium-imprinted nitrogen-doped carbon (Mg–NC) materials is introduced to prepare a platform material to investigate electrocatalytic structure-performance relations. Atomically dispersed Co- and Fe-NCs isomorphic to the pristine Mg-NCs are prepared by ion-exchange…
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Atomically precise silver nanoclusters (Ag NCs) offer unique opportunities to correlate structure and photo-physical properties, yet enhancing their photoluminescence emission remains challenging due to dominance of non-radiative decay pathways. Here, we report a ligand-engineering strategy to modulate the optical…
Juyoung Choi, Daesik Kim, Junghan Oh, Hee Geon Park + 13 more
NUT carcinoma (NC) is an aggressive malignancy driven by NUTM1 gene rearrangements with limited therapeutic options. Here, we show that direct suppression of NUTM1 using CRISPR/Cas9 induces squamous-like differentiation and upregulates TROP2 expression in NC cells. Building on this finding, we developed a…
Alice M. Godden, Nicole Ward, Méghane Sittewelle, Rafeeq Mir + 4 more
Neural crest (NC) multipotent stem cells give rise to many tissues including most of the peripheral nervous system, pigment cells and the craniofacial mesenchyme and skeleton. During gastrulation and early neurulation, cranial NC cells are specified in the ectoderm territory located between the anterior neural plate…
Robert J. Moore, Sungeun An, Farhan Ahmed, Jay Pankaj Gala
The Natural Conversation Benchmark (NC-Bench) introduce a new approach to evaluating the general conversational competence of large language models (LLMs). Unlike prior benchmarks that focus on the content of model behavior, NC-Bench focuses on the form and structure of natural conversation. Grounded in the IBM Natural…
Akiyasu Iwase, Yasunobu Uchijima, Daiki Seya, Mayuko Kida + 23 more
Neural crest cells (NCCs) are multipotent migratory cells essential for cardiac development, yet the lineage trajectories and gene regulatory networks (GRNs) underlying their differentiation in the cardiopharyngeal region remain unclear. Here, we integrate single-cell RNA-seq, spatial transcriptomics, and multiomic…
Waqas Nawaz, Amos Fong, Miguel P. Cardoso, Jing Tang + 9 more
Title: Summary The non-canonical (NC) NF-κB pathway controls peripheral B-cell survival and follicular organization, pointing to a regulatory role during active adaptive immune responses. Here, we show that NC NF-κB activity is selectively attenuated in human germinal center B cells (GCBs), the population required to…
Emma Désert, Michiel Vandenbussche, Marie Monniaux
MADS-box transcription factors specify the identity of floral organs at the primordia stage, but they also have late and spatially-restricted roles in developing or mature floral organs, which we explore in this review. Floral homeotic genes, most of them encoding MADS-box transcription factors, are classically…
Authors not listed
Lead halide perovskite nanocrystals (NCs) are promising materials for light-emitting diodes (LEDs) due to their wavelength tunability, narrow emission line width, and high photoluminescence quantum yield. Oftentimes, these devices suffer from charge carrier imbalance and reduced charge injection because as-synthesized…
Habib Muallem, Alon Zemer, Yulia Haim, Marina Rosengarten-Levin + 10 more
Weight cycling (WC), defined as weight gain, loss, and regain, is common in obesity, but its metabolic consequences remain unclear. We tested whether WC-aggravated glucose intolerance in obesity is age-dependent and linked to circadian disruption. Young (7w) and mid-aged (12m) mice underwent a 15-week dietary…