22 papers · ranked by Valyu relevance
Xing Guo, Run Zhang, Juan Liu, Min Li + 5 more
'Jianyong Li' 'Zheng Ge' 'Obul Reddy Bandapalli'] Aberrant activation of the Wnt pathway plays a pathogenetic role in tumors and has been associated with adverse outcome in acute lymphoblastic leukemia (ALL). Lymphoid enhancer binding factor 1 (LEF1), a key mediator of Wnt signaling, has been linked to leukemic…
Tiffany Carr, Stephanie McGregor, Sheila Dias, Mihalis Verykokakis + 4 more
T lymphocyte acute lymphoblastic leukemia (T-ALL) is a heterogeneous disease affecting T cells at multiple stages of their development and is characterized by frequent genomic alterations. The transcription factor LEF1 is inactivated through mutation in a subset of T-ALL cases but elevated LEF1 expression and…
Yuanyuan Xie, Dan Kaufmann, Matthew J. Moulton, Samin Panahi + 10 more
'John A. Gaynes' 'Harrison N. Watters' 'Dingxi Zhou' 'Hai-Hui Xue' 'Camille M. Fung' 'Edward M. Levine' 'Anthea Letsou' 'K. C. Brennan' 'Richard I. Dorsky' 'Ronald Duman'] While innate behaviors are conserved throughout the animal kingdom, it is unknown whether common signaling pathways regulate the development of…
B. J. H. Ward, Kanchanjunga Prasai, Danielle L. Schaal, Jian Wang + 2 more
As a human tumor virus, EBV is present as a latent infection in its associated malignancies where genetic and epigenetic changes have been shown to impede cellular differentiation and viral reactivation. We reported previously that levels of the Wnt signaling effector, lymphoid enhancer binding factor 1 (LEF1)…
Minxue Jia, Khaled Sayed, Maria G. Kapetanaki, William Dion + 8 more
The study of aging and its mechanisms, such as cellular senescence, has provided valuable insights into age-related pathologies, thus contributing to their prevention and treatment. The current abundance of high throughput data combined with the surge of robust analysis algorithms has facilitated novel ways of…
Yoel Yeretz-Peretz, Shira Anzi, Batia Bell, Ayal Ben-Zvi
The blood-brain barrier (BBB) is a specialized vascular structure essential for CNS homeostasis, whose formation and maintenance are governed by the canonical Wnt signaling pathway. While the upstream ligands and receptors are well-characterized, the downstream transcriptional architecture remains poorly understood.…
Xiaoqi Yang, Haoran Liu, Tao Ye, Zhangqun Ye
Background: Previously published studies have indicated that lymphoid enhancer-binding factor 1 (LEF1) expression could be recognized as a valuable biomarker to evaluate clinical outcome for various types of malignant cancer, but the results remained controversial. Therefore, we conducted this meta-analysis to pool the…
Julia Dräger, Katja Simon-Keller, Tobias Pukrop, Florian Klemm + 7 more
'Jörg Wilting' 'Carsten Sticht' 'Kai Dittmann' 'Matthias Schulz' 'Ivo Leuschner' 'Alexander Marx' 'Heidi Hahn'] Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and show characteristics of skeletal muscle differentiation. The two major RMS subtypes in children are alveolar (ARMS) and embryonal…
Wen-Juan Wang, Yu Yao, Li-Li Jiang, Ting-Hua Hu + 7 more
'Zi-Jun Liao' 'Jun-Tao Yao' 'Dong-Fan Li' 'Shu-Hong Wang' 'Ke-Jun Nan' 'Xin-Yuan Guan'] Expression of lymphoid enhancer factor 1 (LEF1) is frequently altered in different human cancers. This study aimed to assess LEF1 expression in colon cancer tissues and to explore changed phenotypes, gene expressions, and the…
Sema Sırma Ekmekci, Zeliha Emrence, Neslihan Abacı, Melda Sarıman + 3 more
'Burcu Salman' 'Cumhur Gökhan Ekmekci' 'Çağrı Güleç'] Objective: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease resulting from the accumulation of genetic changes that affect the development of T-cells. The precise role of lymphoid enhancer-binding factor 1 (LEF1) in T-ALL has been controversial…
Pin Zhao, Lanming Sun, Cong Zhao, Samiullah Malik
Programmed cell death 1 (PD1) plays a vital role in cancer immune evasion. So monoclonal antibodies targeting PD-1 to boost the immune system are being developed for the treatment of cancer. But the effect of PD1/PD-L1 blocking antibody only works in a subset of patients or some tumors. It is well established that PD-1…
Priscilla Figueroa, Jennifer Cheng, Guangning Wang, Cade Kartchner + 4 more
The vertebrate hypothalamus regulates physiological and behavioral responses to environmental stimuli through the function of evolutionarily-conserved neuronal subpopulations. Our previous work found that mutation of zebrafish lef1, which encodes a transcriptional mediator of the Wnt signaling pathway, leads to the…
Patrick Penner, Anna Vulpetti
Ligand-observed 19F NMR detection is an efficient method for screening libraries of fluorinated molecules in fragment-based drug design campaigns. Screening fluorinated molecules in large mixtures makes 19F NMR a high-throughput method. Typically, these mixtures are generated from pools of well-characterized fragments.…
W. Mu, Xiaonu Xiong, Xiangdong Ji
We perform a theoretical study of the scintillation efficiency in the low-energy region crucial for liquid-xenon dark-matter detectors. We develop a computer program to simulate the cascading process of the recoiling xenon nucleus in liquid xenon and calculate the nuclear quenching effect due to atomic collisions. We…
Elias Polak, Heng Zhao, Stefan Vuckovic
Machine learning (ML) has started to play a pivotal role in extending the reach of quantum chemistry methods for both molecules and materials. However, in density functional theory — the primary workhorse for quantum simulations—using ML to address the limitations of human-designed density functional approximations…
María Rioja, Richard Dodson, T. M. O. Franzen
The ambitious scientific goals of the SKA require a matching capability for calibration of atmospheric propagation errors, which contaminate the observed signals. We demonstrate a scheme for correcting the direction-dependent ionospheric and instrumental phase effects at the low frequencies and with the wide fields of…
Authors not listed
A solid electrolyte interphase (SEI) forms spontaneously during the first few recharging cycles of a lithium-ion battery (LIB) due to electrolyte degradation at the electrodes. The properties of the SEI critically affect the lifespan and stability of LIBs, but the degradation reactions governing SEI formation are…
Huaqing Cheng, Zhixing Ling, Chen Zhang, Xiaojin Sun + 21 more
'Yuan Liu' 'Yanfeng Dai' 'Zhenqing Jia' 'Hai-Wu Pan' 'Wenxin Wang' 'Donghua Zhao' 'Yifan Chen' 'Zhiwei Cheng' 'Wei Fu' 'Y. Han' 'Junfei Li' 'Zhengda Li' 'Xiaohao Ma' 'Yulong Xue' 'Ailiang Yan' 'Qiang Zhang' 'Yusa Wang' 'Xiongtao Yang' 'Zijian Zhao' 'Weimin Yuan'] We report on results of the on-ground X-ray calibration…
Svanhvít Lilja Ingólfsdóttir, Hrafn Loftsson, Jón Friðrik Daðason, Kristín Bjarnadóttir
'Kristín Bjarnadóttir'] Lemmatization, finding the basic morphological form of a word in a corpus, is an important step in many natural language processing tasks when working with morphologically rich languages. We describe and evaluate Nefnir, a new open source lemmatizer for Icelandic. Nefnir uses suffix substitution…
Authors not listed
Glycoconjugates are known to interact with carbohydrate-binding proteins involved in adhesion by pathogens, and offer opportunities to design antimicrobial agents. Metal complexes with Eu(III), Ni(II) and Zn(II) were prepared from glycoconjugate ligand 1Gal, which binds to P. aeruginosa’s lectin LecA (Kd 9.6±0.7 μM).…
C. Cantini, L. Epprecht, A. Gendotti, S. Horikawa + 9 more
'S. Murphy' 'G. Natterer' 'C. Regenfus' 'F. Resnati' 'F. Sergiampietri' 'A. Rubbia' 'T. Viant' 'Shuin Jian Wu'] ABSTRACT: The Large Electron Multipliers (LEMs) are key components of double phase liquid argon TPCs. The drifting charges after being extracted from the liquid are amplified in the LEM positioned half a…
Krzysztof Nowak, Jędrzej Ziębura, Krzysztof Wróbel, Aleksander Smywiński-Pohl
Texts.A Cross-Genre Survey Authors: ['Krzysztof Nowak' 'Jędrzej Ziębura' 'Krzysztof Wróbel' 'Aleksander Smywiński-Pohl'] This study introduces the eFontes models for automatic linguistic annotation of Medieval Latin texts, focusing on lemmatization, partof-speech tagging, and morphological feature determination. Using…