23 papers · ranked by Valyu relevance
Samuel Seidl, Aaron Klausnitzer, Jagdeep Kaur, Pelin Zengin + 1 more
The mechanism of substrate–ATP coupling is central to the function of ABC transporters. Substrates bind to the specialized transmembrane domains (TMDs), whereas ATP binding and hydrolysis occur in the conserved intracellular nucleotide-binding domains (NBDs). Efficient substrate transport requires coupling between…
Aaron Klausnitzer, Jagdeep Kaur, Tobias Rath, Samuel Seidl + 3 more
The outer membrane of Gram-negative bacteria is coated with lipopolysaccharide (LPS). The Lpt system maintains membrane asymmetry by transporting LPS from the inner to the outer membrane. Transport begins with the LptB₂FGC complex, where the ABC transporter LptB₂FG associates with LptC to extract LPS. LPS is then…
Mattia Benedet, Federica A. Falchi, Simone Puccio, Cristiano Di Benedetto + 4 more
'Cristiano Di Benedetto' 'Clelia Peano' 'Alessandra Polissi' 'Gianni Dehò' 'Eric Cascales'] The lipopolysaccharide (LPS) transport (Lpt) system is responsible for transferring LPS from the periplasmic surface of the inner membrane (IM) to the outer leaflet of the outer membrane (OM), where it plays a crucial role in OM…
Cedric Laguri, Paola Sperandeo, Kevin Pounot, Isabel Ayala + 5 more
'Alba Silipo' 'Catherine M. Bougault' 'Antonio Molinaro' 'Alessandra Polissi' 'Jean-Pierre Simorre'] Transport of lipopolysaccharides (LPS) to the surface of the outer membrane is essential for viability of Gram-negative bacteria. Periplasmic LptC and LptA proteins of the LPS transport system (Lpt) are responsible for…
Greg Hicks, Zongchao Jia
Gram-negative bacteria have a dense outer membrane (OM) coating of lipopolysaccharides, which is essential to their survival. This coating is assembled by the LPS (lipopolysaccharide) transport (Lpt) system, a coordinated seven-subunit protein complex that spans the cellular envelope. LPS transport is driven by an…
Aaron Klausnitzer, Jagdeep Kaur, Tobias Rath, Samuel Seidl + 3 more
of LptC Regulates Lipopolysaccharide Transport by the LptB 2 FGC Complex Authors: Aaron Klausnitzer, Jagdeep Kaur, Tobias Rath, Samuel Seidl, Johanna Becker-Baldus, Nina Morgner, Clemens Glaubitz The outer membrane of Gram-negative bacteria is coated with lipopolysaccharide (LPS). The Lpt system generates membrane…
Yixin Ren, Wenting Dong, Yan Li, Weiting Cao + 8 more
'Ying Zhou' 'Yun Teng' 'Xuefu You' 'Xinyi Yang' 'Huoqiang Huang' 'Hao Wang' 'Marilisa Leone'] Antibiotic resistance in Gram-negative bacteria remains one of the most pressing challenges to global public health. Blocking the transportation of lipopolysaccharides (LPS), a crucial component of the outer membrane of…
Hongxin Wang, Jigen Peng, Shigang Yue
—A class of specialized neurons, called lobula plate tangential cells (LPTCs) has been shown to respond strongly to wide-field motion. The classic model, elementary motion detector (EMD) and its improved model, two-quadrant detector (TQD) have been proposed to simulate LPTCs. Although EMD and TQD can percept background…
Marina Dajka, Tobias Rath, Nina Morgner, Benesh Joseph
Lipopolysaccharides (LPS) confer resistance against harsh conditions, including antibiotics, in Gram-negative bacteria. The lipopolysaccharide transport (Lpt) complex, consisting of seven proteins (A-G), exports LPS across the cellular envelope. LptB_2_FG forms an ATP-binding cassette transporter that transfers LPS to…
Tiago Baeta, Karine Giandoreggio-Barranco, Isabel Ayala, Elisabete C.C.M. Moura + 4 more
'Elisabete C.C.M. Moura' 'Paola Sperandeo' 'Alessandra Polissi' 'Jean-Pierre Simorre' 'Cedric Laguri'] Lipopolysaccharide (LPS) is an essential glycolipid that covers the surface of gram-negative bacteria. The transport of LPS involves a dedicated seven-protein transporter system called the lipopolysaccharide transport…
Elisabete C. C. M. Moura, Tiago Baeta, Alessandra Romanelli, Cedric Laguri + 5 more
'Cedric Laguri' 'Alessandra M. Martorana' 'Emanuela Erba' 'Jean-Pierre Simorre' 'Paola Sperandeo' 'Alessandra Polissi'] The outer membrane (OM) of Gram-negative bacteria is a highly selective permeability barrier due to its asymmetric structure with lipopolysaccharide (LPS) in the outer leaflet. In Escherichia coli…
Qinbing Fu, Shigang Yue
— Inspired by insects' visual brains, this paper presents original modelling of a complementary visual neuronal systems model for real-time and robust collision sensing. Two categories of wide-field motion sensitive neurons, i.e., the lobula giant movement detectors (LGMDs) in locusts and the lobula plate tangential…
Eric Vin, Kyle A. Miller, Daniel J. Fremont
We propose LeanLTL, a unifying framework for linear temporal logics in Lean 4. LeanLTL supports reasoning about traces that represent either infinite or finite linear time. The library allows traditional LTL syntax to be combined with arbitrary Lean expressions, making it straightforward to define properties involving…
Noureddine Adjir, Pierre de Saqui‐Sannes, Kamel Mustapha Rahmouni, Abdelkader Adla
'Abdelkader Adla'] Model-based testing of software and hardware systems uses behavioral and formal models of the systems. The paper presents a technique for model-based black-box conformance testing of real-time systems using Labeled Prioritized Time Petri Nets (LPrTPN). The Timed Input/Output Conformance (tioco)…
Anas Rabata, Yujie Qiao, Weini Li, Haohua Huang + 18 more
Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal lung disease marked by alveolar type 2 (AT2) stem cell dysfunction and excessive matrix deposition, with no effective treatments. Recent advances have recognized that AT2 cells act as stem cells, in addition to their role in the production of pulmonary…
Nicholas K Bodmer, Malay Choudhury, Haider Mirza, Suramamayi Pradhan + 5 more
The identification of clinically predictive serum biomarkers for pulmonary fibrosis is a significant challenge and important goal. Multiple recent proteomic biomarker studies have identified latent transforming growth factor binding protein-2 (LTBP2) as a circulating factor associated with disease progression in…
Jennifer Paykin, Steve Zdancewic
This paper defines a new proof- and category-theoretic framework for classical linear logic that separates reasoning into one linear regime and two persistent regimes corresponding to ! and ?. The resulting linear/producer/consumer (LPC) logic puts the three classes of propositions on the same semantic footing…
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We propel photopolymerizable liquid crystalline (LC) shape memory materials from solely elastomeric performance to the thermomechanical performance of tough, yielding thermosets. LC elastomers are at the forefront of smart, stimuli-responsive materials development. To apply their properties to mechanically superior…
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The identification of metrics to assess sustainability of complex chemical synthesis routes has been a topic of interest in recent years. The diversity of life cycle assessment (LCA) approaches for fine chemicals and pharmaceuticals that have been developed face a common challenge: limited availability of production…
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The WRN helicase has recently emerged as a promising therapeutic target for microsatellite instability (MSI)-high cancers. Here, we report LXW-P1, a potent WRN degrader derived from marine bromotyrosine alkaloids. Its molecular target was identified using an AI-guided, pathway-informed perturbation transcriptomics…
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Cells tightly regulate lipid structures to fulfill cellular functions and to respond to external stimuli. The biochemical details of the processes that determine lipid structure alterations are often not fully understood. In this manuscript, we report the discovery of a new epoxidation strategy of unsaturated lipids…
G. Aad, A. V. Akimov, K. Al Khoury, M. Aleksa + 194 more
'C. Anelli' 'N. Aranzabal' 'C. B. Armijo' 'A. Bagulia' 'J. Bán' 'T. Barillari' 'F. Bellachia' 'M. Benoit' 'F. Bernon' 'A. Berthold' 'H. Bervas' 'D. Besin' 'A. Betti' 'Y. Bianga' 'M. Biaut' 'D. Boline' 'J. Boudreau' 'T. Bouedo' 'N. Braam' 'M. Cano Bret' 'G. Brooijmans' 'H. Cai' 'C. Camincher' 'A. Camplani' 'S. Cap' 'A.…
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This review focuses on the synthesis of phenothiazine derivatives employing novel synthetic strategies, including non-metallic reagent-promoted, transition metal-catalysed, and related green chemistry approaches. The therapeutic characteristics of the phenothiazine class are highlighted including antibiotic…