15 papers · ranked by Valyu relevance
Jason Small, Alison Weiss
Enterohemorrhagic Escherichia coli O157:H7 is an enteric pathogen responsible for bloody diarrhea, hemolytic uremic syndrome, and in severe cases even death. The study of O157:H7 is difficult due to the high specificity of the bacteria for the human intestine, along with our lack of sufficiently complex human cell…
Tingting Pu, Min Huang, Xiangyu Kong, Meng Wang + 5 more
'Xixi Feng' 'Changyou Wei' 'Xiechuan Weng' 'Fan Xu'] Background Speech changes occur in the early stages of Parkinson's disease (PD) and cause communication difficulties, leading to social isolation. Lee Silverman voice treatment (LSVT) is a speech therapy approach designed to improve patients' language and voice…
Azzeldin Madkour, Bian Almessiry, Bertha González-Pedrajo, Brendan Kenny
Selection pressure drives rapid emergence of antibiotic resistance mechanisms promoting searches for therapeutic targets in bacterial processes needed for virulence, not viability, which include the Type Three Secretion System (T3SS). Distinct T3SS families evolved from the flagellar export apparatus where remaining…
Xiaoyu Dai, Nivedita Kulkarni, James B. Robinson, Dan J.L. Brett + 2 more
Traditionally, 1D volume-averaged continuum approaches are used to model Li-S battery performance at varying C-rates. For the first time, we present a working three-dimensional electrochemical model of a Li-S battery based on real electrode microstructure. In this study we evaluate the gaps between a volume-averaged 1D…
S. L. Daniels, M. J. Lee, J. George, K. Kerr + 4 more
AppendixS1 Search strategy Table S1 General characteristics of the included studies [Download Media](BJS5-4-1022-s001.docx) Click here for additional data file.
Alan L. F. Lee, Hana Yabuki, Isaac C. L. Lee, Charles C.-F. Or
Visual confidence generally depends on performance in targeted perceptual tasks. However, it remains unclear how factors unrelated to performance affect confidence. Given the hierarchical nature of visual processing, both local and global stimulus features can influence confidence, but their strengths of influence…
Lee F. Peoples
Education and the Profession Authors: ['Lee F. Peoples'] This article reports the results of a study examining the ability of legal and nonlegal Large Language Models (LLMs) to perform legal analysis using the Issue-Rule-Application-Conclusion (IRAC) framework. LLMs were tested on legal reasoning tasks involving rule…
Linda L. Lee, Aarif Y. Khakoo, Vishnu Chintalgattu
Pericytes (PCs) in general are known to help maintain vessel integrity; however, their specific function in the heart is not well defined. Our in vitro study details NG2+ PDGFRβ+ CD146+ CD34− CD31− CD45− cardiac PC phenotypic and functional characteristics, and their role in vasoregulation in physiological and disease…
Jiayi Li, Li Gao, Fengying Pan, Cheng Gong + 6 more
'Jinqiang Zhang' 'Yufei Zhao' 'Guoxiu Wang' 'Hao Liu'] Title: Highlights 1. The electrochemical principles/mechanism of Li-S batteries and origin of the shuttle effect have been discussed. 2. The efficient strategies have been summarized to inhibit the shuttle effect. 3. The recent advances of inhibition of shuttle…
Yi Gong, Jing Li, Kai Yang, Shaoyin Li + 6 more
'Yan Shi' 'Qiong Cai' 'Huanxin Li' 'Yunlong Zhao'] Title: Highlights 1. A comprehensive discussion of the approaches for developing carbon-based sulfur hosts is presented, encompassing structural design and functional optimization. 2. The recent implementation of effective machine learning methods in discovering…
Lianne C. Davis, Rebecca Brain, Grant Churchill, Mallory Factor + 5 more
N-acetyl L-leucine (NALL, USAN or levacetylleucine, INN or trade name Aqneursa™) is an FDA-approved agent for the treatment of Niemann-Pick disease type C (NPC). The N-acetyl group renders the compound a prodrug of L-leucine, making it a substrate for membrane-spanning monocarboxylate transporters (MCTs), which are…
Julia Obergasteiger, Giulia Frapporti, Giulia Lamonaca, Sara Pizzi + 9 more
The Parkinson’s disease (PD)-associated kinase Leucine-Rich Repeat Kinase 2 (LRRK2) is a potent modulator of autophagy and impacts on lysosome biology and function, but unclarity exists on the precise mechanics of its role and the direction of this modulation. LRRK2 is also involved in the degradation of pathological…
Ming-Hsiang Lee, Christine S. Liu, Yunjiao Zhu, Gwendolyn E. Kaeser + 4 more
An APP plasmid contaminant (pGEMT APP) in our single pull-down dataset was found, however we could not definitively determine which APP exon::exon reads were due to gencDNAs vs. contamination, especially in view of the 11 other uncontaminated approaches that had independently identified APP gencDNAs. We therefore…
Huidong Dai, Colin Gallagher, Seong-Min Bak, Luisa Gomes + 7 more
Lithium-sulfur (Li-S) batteries stand as promising candidates for next-generation energy storage systems, offering high specific capacity and cost-effectiveness. However, challenges persist due to the sluggish kinetics of polysulfides conversion and migration. Our study, employing operando X-ray absorption spectroscopy…
Mengting Liu, Ling-Jiao Hu, Zhao-Kun Guan, Tian-Ling Chen + 5 more
'Xin-Yu Zhang' 'Shuai Sun' 'Ruoli Shi' 'Panpan Jing' 'Peng-Fei Wang'] Title: Highlights 1. This review delves into the mechanism of the state-of-the-art lithium-sulfur batteries from a novel perspective of cathode-electrolyte interface. 2. It provides extensive strategies to construct a stable cathode-electrolyte…