23 papers · ranked by Valyu relevance
Sune Justesen, Mikkel Harndahl, Kasper Lamberth, Lise-Lotte B Nielsen + 1 more
'Lise-Lotte B Nielsen' 'Søren Buus'] Background Molecules of the class II major histocompability complex (MHC-II) specifically bind and present exogenously derived peptide epitopes to CD4+ T helper cells. The extreme polymorphism of the MHC-II hampers the complete analysis of peptide binding. It is also a significant…
Laura Santambrogio
In the last few years, advancement in the analysis of the MHC class II (MHC-II) ligandome in several mouse and human haplotypes has increased our understanding of the molecular components that regulate the range and selection of the MHC-II presented peptides, from MHC class II molecule polymorphisms to the recognition…
Adrian Kelly, John Trowsdale
The MHC controls specificity, to ensure that appropriate immune responses are mounted to invading pathogens whilst maintaining tolerance to the host. It encodes molecules that act as sentinels, providing a snapshot of the health of the interior and exterior of the cell for immune surveillance. To maintain the ability…
Long-Chen Shen, Yan Liu, Zi Liu, Yumeng Zhang + 5 more
Accurate prediction of major histocompatibility complex (MHC)-peptide binding affinity can improve our understanding of cellular immune responses and guide personalized immunotherapies. Nevertheless, the existing deep learning-based approaches for predicting MHC-II peptide interactions fall short of satisfactory…
Mette Bøge Pedersen, Sarah Rosenberg Asmussen, Freja Malou Sarfelt, Astrid Brix Saksager + 3 more
Insights into peptide binding to HLA class II molecules is essential when studying the biological mechanisms behind cellular immunity, autoimmune diseases, and the development of immunotherapies and peptide vaccines. Currently, most of the publicly available data used to train state-of-the-art binding prediction…
Wan, Yue, Jiayi Yuan, Zhiwei Feng + 1 more
Antigenic epitope presented by major histocompatibility complex II (MHC-II) proteins plays an essential role in immunotherapy. However, compared to the more widely studied MHC-I in computational immunotherapy, the study of MHC-II antigenic epitope poses significantly more challenges due to its complex binding…
Andressa Fisch, Birkir Reynisson, Lindert Benedictus, Annalisa Nicastri + 8 more
Major histocompatibility complex (MHC) peptide binding and presentation is the most selective event defining the landscape of T cell epitopes. Consequently, understanding the diversity of MHC alleles in a given population and the parameters that define the set of ligands that can be bound and presented by each of these…
Sriram Chitta, Bharti P. Nehete, Ashley B. Delise, Joe H. Simmons + 1 more
1## INTRODUCTION Major histocompatibility complex (MHC) class II proteins are expressed on the surface of professional antigen presenting cells (APC) like dendritic cells (DCs) and B cells. When MHC class II molecules are loaded with peptides derived from invading pathogens, they migrate from intracellular compartments…
Abdoelnaser M. Degoot, Faraimunashe Chirove, Wilfred Ndifon
Major histocompatibility complex class two (MHC-II) molecules are trans-membrane proteins and key components of the cellular immune system. Upon recognition of foreign peptides expressed on the MHC-II binding groove, helper T cells mount an immune response against invading pathogens. Therefore, mechanistic…
Francesco Sabbatino, Luigi Liguori, Giovanna Polcaro, Ilaria Salvato + 6 more
'Gaetano Caramori' 'Francesco A. Salzano' 'Vincenzo Casolaro' 'Cristiana Stellato' 'Jessica Dal Col' 'Stefano Pepe'] Recent advances in cancer immunotherapy have clearly shown that checkpoint-based immunotherapy is effective in a small subgroup of cancer patients. However, no effective predictive biomarker has been…
D.N. Olivieri, S. Mirete-Bachiller, F. Gambón-Deza
Genes of the major class I and II histocompatibility complex have been extensively studied in mammals. Studies of these antigens in reptiles are very scarce. Here we describe the characteristics of these genes in the suborder Serpentes. We identified the presence of a much larger number of molecules of class I and beta…
Unni Grimholt, Brian Dixon
Major histocompatibility complex (MHC) molecules are key players in initiating immune responses towards invading pathogens. Both MHC class I and class II genes are present in teleosts, and, using phylogenetic clustering, sequences from both classes have been classified into various lineages. The polymorphic and…
Samer Halabi, Michael Ghosh, Stefan Stevanović, Hans-Georg Rammensee + 6 more
Viral diseases pose major threats to humans and other animals, including the billions of chickens that are an important food source as well as a public health concern due to zoonotic pathogens. Unlike humans and other typical mammals, the major histocompatibility complex (MHC) of chickens can confer decisive resistance…
Nadine Schubert, Hazel J. Nichols, Francis Mwanguhya, Robert Businge + 4 more
The major histocompatibility complex’s (MHC) role in the vertebrate adaptive immune response and its exceptional polymorphism make it a key target for studying adaptive gene evolution. However, previous studies on carnivore MHC have mostly focused on populations which experienced a severe bottleneck or are of general…
Ayşenaz Ergin, D. Turgay Altılar
The major histocompatibility complex (MHC) molecules, which bind peptides for presentation on the cell surface, play an important role in cell-mediated immunity. In light of developing databases and technologies over the years, significant progress has been made in research on peptide binding affinity calculation.…
liu wenzhong, li hualan
The high mortality of COVID-19 is related to poor antigen presentation and lymphopenia. In this present study, domain search results showed that many proteins of the SARS-COV-2 virus had MHC-like domains, which were similar to decoys for the human immune system. MHC-like structures could bind to MHC receptors of immune…
Earnest Leung, Geoffrey W. Hoffmann
According to Jerne's idiotypic network hypothesis, the adaptive immune system is regulated by interactions between the variable regions of antibodies, B cells, and T cells.1 The symmetrical immune network theory2,3 is based on Jerne's hypothesis, and provides a basis for understanding many of the phenomena of adaptive…
Tajudeen Yahaya, Titilola Salisu
The possibility of targeting the causal genes along with the mechanisms of pathogenically complex diseases has led to numerous studies on the genetic etiology of some diseases. In particular, studies have added more genes to the list of type 1 diabetes mellitus (T1DM) suspect genes, necessitating an update for the…
Authors not listed
Background: Antimicrobial peptides (AMPs) of bacterial origin are considered as a promising alternative to traditional antibiotics and a good solution to the problem of antibiotic resistance. Additionally, many of them exhibit other types of biological activity. Therefore, in recent years, the interest of researchers…
Hans-Christof Gasser, Georges Bedran, Bo Ren, David R. Goodlett + 2 more
MHC class I proteins Authors: ['Hans-Christof Gasser' 'Georges Bedran' 'Bo Ren' 'David R. Goodlett' 'Javier A. Alfaro' 'Ajitha Rajan'] The major histocompatibility complex (MHC) class-I pathway supports the detection of cancer and viruses by the immune system. It presents parts of proteins (peptides) from inside a cell…
Yeeleng S. Vang, Xiaohui Xie
Many biological processes are governed by protein-ligand interactions. One such example is the recognition of self and nonself cells by the immune system. This immune response process is regulated by the major histocompatibility complex (MHC) protein which is encoded by the human leukocyte antigen (HLA) complex.…
Alison Caldwell, Rachel Coleby, Cesar Tovar, Maximilian R Stammnitz + 12 more
'Young Mi Kwon' 'Rachel S Owen' 'Marios Tringides' 'Elizabeth P Murchison' 'Karsten Skjødt' 'Gareth J Thomas' 'Jim Kaufman' 'Tim Elliott' 'Gregory M Woods' 'Hannah VT Siddle' 'Arup K Chakraborty' 'Ronald N Germain'] Devil Facial Tumour 2 (DFT2) is a recently discovered contagious cancer circulating in the Tasmanian…
Authors not listed
Proteolysis-targeting chimeras (PROTACs) are emerging new therapeutic modalities that facilitate the targeted degradation of disease-relevant proteins via an event-driven mode of action. In this work, we report the design, synthesis, and biological evaluation of the first-in-class selective degraders of the class IIb…