19 papers · ranked by Valyu relevance
Laura Santambrogio
In the last few years, advancement in the analysis of the MHC class II (MHC-II) ligandome in several mouse and human haplotypes has increased our understanding of the molecular components that regulate the range and selection of the MHC-II presented peptides, from MHC class II molecule polymorphisms to the recognition…
Zhuldyz Zhanzak, Davide Cina, Aileen C. Johnson, Christian P. Larsen
The peptide presentation by donor and recipient major histocompatibility complex (MHC) molecules is the major driver of T-cell responses in transplantation. In this review, we address an emerging area of interest, the application of immunopeptidome in transplantation, and describe the potential opportunities that exist…
Wan, Yue, Jiayi Yuan, Zhiwei Feng + 1 more
Antigenic epitope presented by major histocompatibility complex II (MHC-II) proteins plays an essential role in immunotherapy. However, compared to the more widely studied MHC-I in computational immunotherapy, the study of MHC-II antigenic epitope poses significantly more challenges due to its complex binding…
Julien Racle, David Gfeller
MHC-II molecules are key mediators of antigen presentation in vertebrate species and bind to their ligands with high specificity. The very high polymorphism of MHC-II genes within species and the fast-evolving nature of these genes across species has resulted in tens of thousands of different alleles, with hundreds of…
Long-Chen Shen, Yan Liu, Zi Liu, Yumeng Zhang + 5 more
Accurate prediction of major histocompatibility complex (MHC)-peptide binding affinity can improve our understanding of cellular immune responses and guide personalized immunotherapies. Nevertheless, the existing deep learning-based approaches for predicting MHC-II peptide interactions fall short of satisfactory…
Reham Afify, Katherine Lipsius, Season J. Wyatt-Johnson, Randy R. Brutkiewicz
'Randy R. Brutkiewicz'] In recent years, increasing evidence has highlighted the critical role of myeloid cells, specifically those that present antigen (APCs) in health and disease. These shape the progression and development of neurodegenerative disorders, where considerable interplay between the immune system and…
Mette Bøge Pedersen, Sarah Rosenberg Asmussen, Freja Malou Sarfelt, Astrid Brix Saksager + 3 more
Insights into peptide binding to HLA class II molecules is essential when studying the biological mechanisms behind cellular immunity, autoimmune diseases, and the development of immunotherapies and peptide vaccines. Currently, most of the publicly available data used to train state-of-the-art binding prediction…
Sen Liu, Shaoqiang Wei, Yan Sun, Guowei Xu + 3 more
'Jianxi Li' 'Cheorl-Ho Kim'] The major histocompatibility complexes of vertebrates play a key role in the immune response. Antigen-presenting cells are loaded on MHC I molecules, which mainly present endogenous antigens; when MHC I presents exogenous antigens, this is called cross-presentation. The discovery of…
Sriram Chitta, Bharti P. Nehete, Ashley B. Delise, Joe H. Simmons + 1 more
1## INTRODUCTION Major histocompatibility complex (MHC) class II proteins are expressed on the surface of professional antigen presenting cells (APC) like dendritic cells (DCs) and B cells. When MHC class II molecules are loaded with peptides derived from invading pathogens, they migrate from intracellular compartments…
Arne Claeys, Jasper Staut, Peter Merseburger, Kathleen Marchal + 1 more
The HLA genes are a group of highly polymorphic genes that are located in the MHC region on chromosome 6. The HLA genotype affects the presentability of tumour antigens to the immune system. Therefore, methods to accurately type HLA alleles are critical to study differences in immune response between cancer patients.…
Alyssa Lyn Fortier, Jonathan K Pritchard, David Enard, Detlef Weigel
Gene families are groups of evolutionarily related genes. One large gene family that has experienced rapid evolution lies within the Major Histocompatibility Complex (MHC), whose proteins serve critical roles in innate and adaptive immunity. Across the ∼60 million year history of the primates, some MHC genes have…
Alyssa Lyn Fortier, Jonathan K. Pritchard
Gene families are groups of evolutionarily-related genes. One large gene family that has experienced rapid evolution is the Major Histocompatibility Complex (MHC), whose proteins serve critical roles in innate and adaptive immunity. Across the ∼60 million year history of the primates, some MHC genes have turned over…
Ayşenaz Ergin, D. Turgay Altılar
The major histocompatibility complex (MHC) molecules, which bind peptides for presentation on the cell surface, play an important role in cell-mediated immunity. In light of developing databases and technologies over the years, significant progress has been made in research on peptide binding affinity calculation.…
Nadine Schubert, Hazel J. Nichols, Francis Mwanguhya, Robert Businge + 4 more
The major histocompatibility complex’s (MHC) role in the vertebrate adaptive immune response and its exceptional polymorphism make it a key target for studying adaptive gene evolution. However, previous studies on carnivore MHC have mostly focused on populations which experienced a severe bottleneck or are of general…
Joana Sabino-Pinto, Martine E. Maan
The major histocompatibility complex (MHC) is a cluster of functionally related genes encoding proteins which, among other functions, mediate immune system activation. While the MHC of many vertebrates has been extensively studied, less is known about the amphibian MHC. This represents an important knowledge gap…
D. P. L. Green
variation, can account for balancing selection and MHC/HLA polymorphism Authors: ['D. P. L. Green'] The human MHC transplantation loci (HLA-A, -B, -C, -DPB1, -DQB1, -DRB1) are the most polymorphic in the human genome. It is generally accepted this polymorphism reflects a rôle in presenting pathogen-derived peptide to…
Hans-Christof Gasser, Georges Bedran, Bo Ren, David R. Goodlett + 2 more
MHC class I proteins Authors: ['Hans-Christof Gasser' 'Georges Bedran' 'Bo Ren' 'David R. Goodlett' 'Javier A. Alfaro' 'Ajitha Rajan'] The major histocompatibility complex (MHC) class-I pathway supports the detection of cancer and viruses by the immune system. It presents parts of proteins (peptides) from inside a cell…
Authors not listed
Background: Antimicrobial peptides (AMPs) of bacterial origin are considered as a promising alternative to traditional antibiotics and a good solution to the problem of antibiotic resistance. Additionally, many of them exhibit other types of biological activity. Therefore, in recent years, the interest of researchers…
Authors not listed
Proteolysis-targeting chimeras (PROTACs) are emerging new therapeutic modalities that facilitate the targeted degradation of disease-relevant proteins via an event-driven mode of action. In this work, we report the design, synthesis, and biological evaluation of the first-in-class selective degraders of the class IIb…