25 papers · ranked by Valyu relevance
Xiaqiang Tang, Weigao Sun, Siyuan Hu, Yiyang Sun + 1 more
—The multi-modality and stochastic characteristics of human behavior make motion prediction a highly challenging task, which is critical for autonomous driving. While deep learning approaches have demonstrated their great potential in this area, it still remains unsolved to establish a connection between multiple…
Korrawe Karunratanakul, Hsin-Yao Tang, David W. Speicher, Ekapol Chuangsuwanich + 1 more
Typical analyses of mass spectrometry data only identify amino acid sequences that exist in reference databases. This restricts the possibility of discovering new peptides such as those that contain uncharacterized mutations or originate from unexpected processing of RNAs and proteins. De novo peptide sequencing…
Moyuan Quan, Huining Zhang, Xiaohong Deng, Huijia Liu + 2 more
'Xiujuan Song'] Multiple sclerosis (MS), a chronic inflammatory and degenerative autoimmune disease characterized by the activation of various inflammatory cells, leads to demyelination and neuronal injury. Neutrophils, often underestimated in MS, are gaining increased attention for their significant functions in MS…
Sandra Meyer-Moock, Susan Raths, Katharina Strunk, Bernward Siebert + 4 more
'Katrin Hinkfoth' 'Markus Weih' 'Steffen Fleßa' 'Thomas Kohlmann'] Background Multiple Sclerosis is an autoimmune inflammatory disease of the central nervous system that often leads to premature incapacity for work. Therefore, the MSnetWork project implements a new form of care and pursues the goal of maintaining or…
Da Jeong Byun, Jaeho Lee, Kyungryung Ko, Young-Min Hyun
Background Neutrophil extracellular trap (NET) has been implicated in the pathology of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). However, the specific contributions of NLRP3, a NET-associated molecule, to EAE pathogenesis and its regulatory role in NET formation remain unknown.…
Rukiye Polattimur, Mehmet Süleyman Yıldırım, Emre Dandıl, Zhuhuang Zhou
'Zhuhuang Zhou'] Background/Objectives: Multiple sclerosis (MS) is an autoimmune disease that damages the myelin sheath of the central nervous system, which includes the brain and spinal cord. Although MS lesions in the brain are more frequently investigated, MS lesions in the cervical spinal cord (CSC) can be much…
Hellaoui, Hamed, Laitila, Matti + 4 more
—The upcoming generation of mobile telecommunication systems is expected to support new use cases, where the mobile network serves one or more IP subnetworks located behind the User Equipment (UEs). This would create new challenges for the mobile system to efficiently serve such behind-UE subnetworks, as the latter are…
Anthony J. O’Donoghue, Ye Jin, Giselle M. Knudsen, Natascha C. Perera + 5 more
'Natascha C. Perera' 'Dieter E. Jenne' 'John E. Murphy' 'Charles S. Craik' 'Terry W. Hermiston' 'Michael Glogauer'] Neutrophil extracellular traps (NETs) consist of antimicrobial molecules embedded in a web of extracellular DNA. Formation of NETs is considered to be a defense mechanism utilized by neutrophils to…
Anis Elloumi, Lindsay Mas-Normand, Jamie Bride, Guillaume Reversat + 9 more
Oxylipins, small polar molecules derived from the peroxidation of polyunsaturated fatty acids (PUFAs), serve as biomarkers for many diseases and play crucial roles in human physiology and inflammation. Despite their significance, many non-enzymatic oxygenated metabolites of PUFAs (NEO-PUFAs) remain poorly reported…
Alejandro Cohen, Homa Esfahanizadeh, Bruno Sousa, João P. Vilela + 5 more
'Miguel Luís' 'Duarte Raposo' 'Michel François' 'Susana Sargento' 'Muriel Médard'] Modern communications have moved away from point-to-point models to increasingly heterogeneous network models. In this article, we propose a novel controller-based protocol to deploy adaptive causal network coding in heterogeneous and…
Chanel Avenant, Johnson Mosoko Moliki, Alexis J. Bick, Sigcinile Dlamini + 7 more
'Sigcinile Dlamini' 'Mandisa Singata-Madliki' 'G. Justus Hofmeyr' 'Pai-Lien Chen' 'Karl-Heinz Storbeck' 'Donita J. Africander' 'David W. Erikson' 'Janet P. Hapgood'] Background The progestin norethisterone (NET), which is structurally related to testosterone, and its enanthate form (NET-EN), are used in contraception…
Fernando Vargas, Kelly C. Weldon, Nicole Sikora, Mingxun Wang + 6 more
A major hurdle in identifying chemicals in mass spectrometry experiments is the availability of MS/MS reference spectra in public databases. Currently, scientists purchase databases or use public databases such as GNPS. The MSMS-Chooser workflow empowers the creation of MS/MS reference spectra directly in the GNPS…
Ditmar Parmeza, Miraldi Fifo
The technology evolution has shown a very impressive performance in the last years by introducing several technologies that are based on the concept of component. As time passes, new versions of Component-Based technologies are released in order to improve services provided by previous ones. One important issue that…
Robert Courter, Enrique Alvarez, Roger Enoka, Alaa Ahmed
Movement slowness is a common and disruptive symptom of multiple sclerosis (MS). A potential cause is that individuals with MS slow down to conserve energy as a behavioral adjustment to heightened metabolic costs of movement. To investigate this prospect, we measured the metabolic costs of both walking and seated arm…
David Degnan, Kevin Zemaitis, Logan Lewis, Lee Ann McCue + 5 more
Due to its speed, accuracy, and adaptability to various sample types, matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has become a popular method to identify molecular isotope profiles from biological samples. Often MALDI-MS data does not include tandem MS fragmentation data, and thus the…
Wout Bittremieux, Mingxun Wang, Pieter C. Dorrestein
Background: Spectral library searching is currently the most common approach for compound annotation in untargeted metabolomics. Spectral libraries applicable to liquid chromatography mass spectrometry have grown in size over the past decade to include hundreds of thousands to millions of mass spectra and tens of…
Ramya Mohan
This paper outlines a comprehensive model to increase system efficiency, preserve network bandwidth, monitor incoming and outgoing packets, ensure the security of confidential files and reduce power wastage in an organization. This model illustrates the use and potential application of a Network Analysis Tool (NAT) in…
Mariam Akbar, Nadeem Javaid, Abid Khan, Zahoor Ali Khan + 1 more
Moving Sink (MS) in Wireless Sensor Networks (WSNs) has appeared as a blessing because it collects data directly from the nodes where the concept of relay nodes is becomes obsolete. There are, however, a few challenges to be taken care of, like data delay tolerance and trajectory of MS which is NP-hard. In our proposed…
Charlie Bayne, Brianna Hurysz, David J. Gonzalez, Anthony O’Donoghue
Multiplex Substrate Profiling by Mass Spectrometry (MSP-MS) is a powerful method for determining the substrate specificity of proteolytic enzymes, knowledge key for developing protease inhibitors, diagnostics, and protease-activated therapeutics. However, the complex datasets generated by MSP-MS pose significant…
Jongham Park, Ahrum Son, Hyunsoo Kim
The formation of protein networking is critical for understanding the biological functions of proteins and the underlying mechanisms of disease. To gain insights into target proteins that interact with a particular disease, we need to profiling all the proteins involved in the disease beforehand. However, the profiling…
Georg Wallmann, Andrew Leduc, Nikolai Slavov
Mass-spectrometry (MS) enables specific and accurate quantification of proteins with ever increasing throughput and sensitivity. Maximizing this potential of MS requires optimizing data acquisition parameters and performing efficient quality control for large datasets. To facilitate these objectives for data…
Authors not listed
Mass spectrometry-based natural products targeted discovery often relies on a complicated decision-making process involving tedious comparison of exact masses data and tandem mass spectra-based annotation tools output against various spectral reference libraries. To address this bottleneck, we present tandem mass…
Hyung-Wook Choi, Byeongchan Lee, Un-Beom Kang, Sunghyun Huh
Computational workflows for MS-based proteomics remain comparatively fragmented, with heterogeneous data formats and analysis pipelines that hinder their reproducibility, interoperability, and reuse of processed data. We present msmu, an open-source Python package that implements a flexible and reproducible end-to-end…
Authors not listed
Mass spectrometry (MS) generates large datasets that are stored in increasingly optimized and complex file types, demanding technical expertise to extract information rapidly and easily. We wondered whether a simple structured query language (SQL) database could hold raw MS data and allow for easily readable queries…
Authors not listed
MALDI MS analysis of liquid biopsy combined with ML enables non-invasive disease screening and monitoring. Presented an open-source R-based workflow covering all steps from raw data preprocessing to predictive model evaluation. The pipeline is customizable, transparent, and validated on clinical plasma samples from…