Search · four archives
Search · four archives
26 papers · ranked by Valyu relevance
Simone Sommer
Genetic studies have typically inferred the effects of human impact by documenting patterns of genetic differentiation and levels of genetic diversity among potentially isolated populations using selective neutral markers such as mitochondrial control region sequences, microsatellites or single nucleotide polymorphism…
Beata Ujvari, Katherine Belov
Human impacts through habitat destruction, introduction of invasive species and climate change are increasing the number of species threatened with extinction. Decreases in population size simultaneously lead to reductions in genetic diversity, ultimately reducing the ability of populations to adapt to a changing…
Marco Antonio Ayala García, Beatriz González Yebra, Andrea Liliana López Flores, Eduardo Guaní Guerra
'Andrea Liliana López Flores' 'Eduardo Guaní Guerra'] The transplant of organs is one of the greatest therapeutic achievements of the twentieth century. In organ transplantation, the adaptive immunity is considered the main response exerted to the transplanted tissue, since the principal target of the immune response…
Alice Bertaina, Marco Andreani
Allogeneic hematopoietic stem cell transplantation (HSCT) represents a curative treatment for many patients with hematological malignant or non-malignant disorders. Evaluation of potential donors for HSCT includes a rigorous assessment of the human leukocyte antigens (HLA) match status of family members, and the…
M. Yu. Zakharova, T. A. Belyanina, A. V. Sokolov, I. S. Kiselev + 1 more
'A. E. Mamedov'] Genetic studies of patients with autoimmune diseases have shown that one of the most important roles in the developing of these diseases is played by a cluster of genes of the major histocompatibility complex (MHC), as compared with other genome areas. Information on the specific contribution of MHC…
Sen Liu, Shaoqiang Wei, Yan Sun, Guowei Xu + 3 more
'Jianxi Li' 'Cheorl-Ho Kim'] The major histocompatibility complexes of vertebrates play a key role in the immune response. Antigen-presenting cells are loaded on MHC I molecules, which mainly present endogenous antigens; when MHC I presents exogenous antigens, this is called cross-presentation. The discovery of…
Navyatha Peddi, Dharani Reddy Bijjula, Sanjana Gogte, Vani Kondaparthi
Major Histocompatibility Complex (MHC) molecules are essential to the immune system because they bind and present peptide antigens to T cells, enabling immune recognition and response. The specificity of MHC-peptide interactions is crucial for understanding immune-related diseases, developing personalized…
W. Babik, K. Dudek, G. Palomar, M. Marszałek + 3 more
Major Histocompatibility Complex (MHC) molecules are central to vertebrate adaptive immunity and MHC genes serve are key models in evolutionary genomics, offering insight into birth-and-death evolution, gene duplication, and the maintenance of genetic diversity. However, the organization and evolution of the MHC in…
D.N. Olivieri, F. Gambón-Deza
The major histocompatibility complex (MHC) molecule plays a central role in the adaptive immunity of jawed vertebrates. Allelic variations have been studied extensively in some primate species, however a comprehensive description of the number of genes remains incomplete. Here, a bioinformatics program was developed to…
Nadine Schubert, Hazel J. Nichols, Francis Mwanguhya, Robert Businge + 4 more
The major histocompatibility complex’s (MHC) role in the vertebrate adaptive immune response and its exceptional polymorphism make it a key target for studying adaptive gene evolution. However, previous studies on carnivore MHC have mostly focused on populations which experienced a severe bottleneck or are of general…
Alyssa Lyn Fortier, Jonathan K Pritchard, David Enard, George H Perry
Classical genes within the Major Histocompatibility Complex (MHC) are responsible for peptide presentation to T cells, thus playing a central role in immune defense against pathogens. These genes are subject to strong selective pressures including both balancing and directional selection, resulting in exceptional…
D.N. Olivieri, S. Mirete-Bachiller, F. Gambón-Deza
Genes of the major class I and II histocompatibility complex have been extensively studied in mammals. Studies of these antigens in reptiles are very scarce. Here we describe the characteristics of these genes in the suborder Serpentes. We identified the presence of a much larger number of molecules of class I and beta…
Joana Sabino-Pinto, Martine E. Maan
The major histocompatibility complex (MHC) is a cluster of functionally related genes encoding proteins which, among other functions, mediate immune system activation. While the MHC of many vertebrates has been extensively studied, less is known about the amphibian MHC. This represents an important knowledge gap…
Mette Bøge Pedersen, Sarah Rosenberg Asmussen, Freja Malou Sarfelt, Astrid Brix Saksager + 3 more
Insights into peptide binding to HLA class II molecules is essential when studying the biological mechanisms behind cellular immunity, autoimmune diseases, and the development of immunotherapies and peptide vaccines. Currently, most of the publicly available data used to train state-of-the-art binding prediction…
Ayşenaz Ergin, D. Turgay Altılar
The major histocompatibility complex (MHC) molecules, which bind peptides for presentation on the cell surface, play an important role in cell-mediated immunity. In light of developing databases and technologies over the years, significant progress has been made in research on peptide binding affinity calculation.…
Abdoelnaser M. Degoot, Faraimunashe Chirove, Wilfred Ndifon
Major histocompatibility complex class two (MHC-II) molecules are trans-membrane proteins and key components of the cellular immune system. Upon recognition of foreign peptides expressed on the MHC-II binding groove, helper T cells mount an immune response against invading pathogens. Therefore, mechanistic…
Montgomery Slatkin
A composite likelihood method is introduced for jointly estimating the intensity of selection and the rate of mutation, both scaled by the effective population size, when there is balancing selection at a single multi-allelic locus in an isolated population at demographic equilibrium. The performance of the method is…
Johanna Vielhaben, Markus Wenzel, Eva Weicken, Nils Strodthoff
Predicting the binding of viral peptides to the major histocompatibility complex with machine learning can potentially extend the computational immunology toolkit for vaccine development, and serve as a key component in the fight against a pandemic. In this work, we adapt and extend USMPep, a recently proposed…
Yeeleng S. Vang, Xiaohui Xie
Many biological processes are governed by protein-ligand interactions. One such example is the recognition of self and nonself cells by the immune system. This immune response process is regulated by the major histocompatibility complex (MHC) protein which is encoded by the human leukocyte antigen (HLA) complex.…
Charlotte Adams, Kris Laukens, Wout Bittremieux, Kurt Boonen
Immunopeptidomics is a key technology in the discovery of targets for immunotherapy and vaccine development. However, identifying immunopeptides remains challenging due to their non-tryptic nature, which results in distinct spectral characteristics. Moreover, the absence of strict digestion rules leads to extensive…
Badar Abdul Razzaq, Allison F. Scalora, Vishal N. Kopardé, Jeremy A. Meier + 13 more
'Jeremy A. Meier' 'Manzoor Mahmood' 'Sanaa Moussa Salman' 'Max Jameson‐Lee' 'Manuel Serrano' 'N Sheth' 'Mark Voelkner' 'David J. Kobulnicky' 'Catherine Roberts' 'Andrea Ferreira‐Gonzalez' 'M.H. Manjili' 'Gemma Buck' 'MC Neale' 'Amir A. Toor'] Immune reconstitution kinetics and subsequent clinical outcomes in HLA…
Juliana K. Sampson, Nihar U. Sheth, Vishal N. Kopardé, Allison F. Scalora + 9 more
'Allison F. Scalora' 'Myrna G. Serrano' 'Vladimir Lee' 'Catherine Roberts' 'Maximilian Jameson-Lee' 'Andrea Ferriera-Gonzalez' 'Masoud H. Manjili' 'Gregory A. Buck' 'Michael C. Neale' 'Amir A. Toor'] Graft versus host disease (GVHD) continues to afflict allogeneic hematopoietic stem cell transplant (SCT) recipients…
Jérôme Eberhardt, Markus Lill, Torsten Schwede
This study introduces a novel Bayesian Optimization (BO) method to support the design and optimization of bioactive peptide sequences in the context of a fully automated closed-loop Design-Make-Test (DMT) pipeline. Using the major histocompatibility complex class I receptor system as test case, we showed that BO is…
Authors not listed
Streptavidin enjoys numerous biotechnological applications due to its extraordinarily high affinity for biotin and the ease of biotinylation of targets through chemical or biological means. However, two main drawbacks limit its use in therapeutic and diagnostic applications: high immunogenicity and endogenous biotin…
Authors not listed
Immuno-oncology, a rapidly evolving field at the forefront of cancer research, leverages the body’s immune system to fight cancer. In this follow up report, we extend our natural language processing (NLP)-based analysis to pinpoint the context of emergence of the previously identified emerging concepts. To achieve this…
Authors not listed
Melanoma is a type of skin cancer originating in the melanocytes and is recognized as one of the most severe and challenging forms of skin cancer to treat. Tyrosinase-related protein 1 (TYRP1) is a crucial protein involved in melanin production and is notably overexpressed in melanoma cells. Recently, TYRP1 has been…