24 papers · ranked by Valyu relevance
Beoung Hun Lee, Zexun Wu, Suhn K. Rhie
Background Regulatory elements such as promoters, enhancers, and insulators interact each other to mediate molecular processes. To capture chromatin interactions of regulatory elements, 3C-derived methods such as Hi-C and Micro-C are developed. Here, we generated and analyzed Hi-C, Micro-C, and promoter capture Micro-C…
Tsung-Han S. Hsieh, Geoffrey Fudenberg, Anton Goloborodko, Oliver J. Rando
Structural analysis of chromosome folding in vivo has been revolutionized by Chromosome Conformation Capture (3C) and related methods, which use proximity ligation to identify chromosomal loci in physical contact. We recently described a variant 3C technique, Micro-C, in which chromatin is fragmented to mononucleosomes…
Abbas Roayaei Ardakany, Halil Tuvan Gezer, Stefano Lonardi, Ferhat Ay
We present Mustache, a new method for multi-scale detection of chromatin loops from Hi-C and Micro-C contact maps. Mustache employs scale-space theory, a technical advance in computer vision, to detect blob-shaped objects in a multi-scale representation of chromatin contact maps parametrized by the size of the…
Tong Liu, Hao Zhu, Zheng Wang, Jie Liu
In the last few years, Micro-C has shown itself as an improved alternative to Hi-C. It replaced the restriction enzymes in Hi-C assays with micrococcal nuclease (MNase), resulting in capturing nucleosome resolution chromatin interactions. The signal-to-noise improvement of Micro-C allows it to detect more chromatin…
Mariia Metelova, Nils Krietenstein
The regulation of cell-type-specific transcription programs is a highly controlled and complex process that needs to be fully understood. The gene regulation is often influenced by distal regulatory elements and their interactions with promoters in three-dimensional space. Although proximity ligation techniques like…
Koosha Karimi, Ali Fardoost, Nikhil Mhatre, Jay Rajan + 4 more
In recent years, the field of micro- and nanochannel fabrication has seen significant advancements driven by the need for precision in biomedical, environmental, and industrial applications. This review provides a comprehensive analysis of emerging fabrication technologies, including photolithography, soft lithography…
Robert Bird, Xiang Yu, Otilia Catanescu, Shalini Gupta + 2 more
The growing usage of plastics in their various forms and applications has resulted in an exponential increase and spread of microplastics throughout the environment. We present a review based on a comprehensive analysis of the CAS content collection on the awareness of the underlying detrimental effects of several…
Authors not listed
During charge/discharge cracking occurs in Nickel Manganese Cobalt (NMC) secondary particles. Secondary particles with cracks will have observably lower grey-levels in micro-CT datasets compared to an otherwise identical pristine particle. This is due to the ‘partial volume effect’ where voxels representative of space…
Benedykt R. Jany
ARTICLE INFO Keywords: Microscopy Hyperspectral Reflectance Color Science Colorimetric Microscopy C-Microscopy ABSTRACT The color is the primal property of the objects around us and is direct manifestation of light-matter interactions. The color information is used in many different fields of science, technology and…
Thierry Dufour, Lawrence Overzet, Rémi Dussart, Leanne C. Pitchford + 4 more
'N. Sadeghi' 'Philippe Lefaucheux' 'Mukesh Kulsreshath' 'P. Ranson'] | Title | Experimental study and simulation of a micro-discharge with limited cathode area | | --- | --- | | Authors | T. Dufour1 , L.J. Overzet2 , R. Dussart1 , L.C. Pitchford3 , N. Sadeghi4 , P. Lefaucheux1 , M. Kulsreshath1 , and P. Ranson1 | |…
Leonid A. Krivitsky, Jia Jun Wang, Zengbo Wang, Boris Lukiyanchuk
Super-resolution virtual imaging by micron sized transparent beads (microspheres) was recently demonstrated by Wang et al.. Practical applications in microscopy require control over the positioning of the microspheres. Here we present a method of positioning and controllable movement of a microsphere by using a fine…
Authors not listed
The capacity to pattern biomolecules within microfluidic devices expands the scope of microfluidic technologies. In such patterned systems, surface-bound components remained localized, while the microfluidic network supplies reagents and removes waste products. This approach has enabled continuous protein expression…
G.V. Prasad Reddy, C. Robertson, C. Déprés, Marc Fivel
Three-dimensional dislocation dynamics simulations are used to study micro-crack interaction with the first micro-structural barrier in face-centred cubic bi-crystals loaded in high cycle fatigue conditions. In the examined configuration, we assumed that micro-crack transmission occurs due to surface relief growth in…
Yağmur Ceren Alataş, Uzay Tefek, Sayedus Salehin, Hashim Alhmoud + 1 more
Microwave Cytometry with 3D Electrodes Authors: ['Yağmur Ceren Alataş' 'Uzay Tefek' 'Sayedus Salehin' 'Hashim Alhmoud' 'M. Selim Hanay'] ABSTRACT: Rapid identification of microparticles in liquid is an important problem in environmental and biomedical applications such as for microplastic detection in water sources and…
Amid Shakeri, Shadman Khan, Noor Abu Jarad, Tohid Didar
Various fields within biomedical engineering have been afforded rapid scientific advancement through the incorporation of microfluidics. As literature surrounding biological systems become more comprehensive and many microfluidic platforms show potential for commercialization, the development of representative fluidic…
R. D. Smith, I. Kolb, S. Tanaka, A. K. Lee + 2 more
Electrophysiology is one of the major experimental techniques used in neuroscience. The favorable spatial and temporal resolution as well as the increasingly larger site counts of brain recording electrodes contribute to the popularity and importance of electrophysiology in neuroscience. Such electrodes are typically…
Purnesh Chattopadhyay, Maria Camila Ariza Tarazona, Erika Iveth Cedillo-Gonzlez, Cristina Siligardi + 1 more
Microplastics are a significant environmental threat as they are not regularly monitored or removed and the lack of efficient removal techniques further amplifies this crisis. In this direction and many other environmental remediation processes, photocatalytic micro/nanomotors hold vast potential to remove and degrade…
Yung-Yi Wu, Tzu-Wei Huang, Dong-Yea Sheu
Tungsten cemented carbide (WC-Co) is a widely applied material in micro-hole drilling, such as in suction nozzles, injection nozzles, and wire drawing dies, owing to its high wear resistance and hardness. Since the development of wire-electro-discharge grinding (WEDG) technology, the micro-electrical discharge…
Hengji Cong, Nan Zhang
Transforming lab research into a sustainable business is becoming a trend in the microfluidic field. However, there are various challenges during the translation process due to the gaps between academia and industry, especially from laboratory prototyping to industrial scale-up production, which is critical for…
Joran Deschamps, Christian Kieser, Philipp Hoess, Takahiro Deguchi + 1 more
Modern microscopy relies increasingly on microscope automation to improve throughput, ensure reproducibility or observe rare events. Automation requires in particular computer control of the important elements of the microscope. Furthermore, optical elements that are usually fixed or manually movable can be placed on…
Yi-Je Juang, Yu-Jui Chiu, Arash Nikoubashman
Microfluidic platform technology has presented a new strategy to detect and analyze analytes and biological entities thanks to its reduced dimensions, which results in lower reagent consumption, fast reaction, multiplex, simplified procedure, and high portability. In addition, various forces, such as hydrodynamic…
Adva Raz, Hila Gubi, Adam Cohen, Fernando Patolsky
Biomarkers detection have become essential in medical diagnostics and early detection of life-threatening diseases. Modern-day medicine relies heavily on painful and invasive tests, the extraction of large volumes of venous blood being the most common tool of biomarker detection. These tests are time-consuming…
J. S. Adams, A. J. Anderson, R. Baker, S. R. Bandler + 20 more
J. S. Adams1 · A. J. Anderson1 · R. Baker1 · S. R. Bandler1 · N. Bastidon1 · D. Castro1 · M. E. Danowski1 · W. B. Doriese1 · M. E. Eckart1 · E. Figueroa-Feliciano1 · D. C. Goldfinger1 · S. N. T. Heine1 · G. C. Hilton1 · A. J. F. Hubbard1 · R. L. Kelley1 · C. A. Kilbourne1 · R. E. Manzagol-Harwood1 · D. McCammon1 · T.…
Laura Jasińska, Karol Malecha, Paola Russo
The constant increase in the number of microfluidic-microwave devices can be explained by various advantages, such as relatively easy integration of various microwave circuits in the device, which contains microfluidic components. To achieve the aforementioned solutions, four trends of manufacturing…