19 papers · ranked by Valyu relevance
Stephen J. Beckett, Joshua S. Weitz
Infection and lysis of phytoplankton by viruses affects population dynamics and nutrient cycles within oceanic microbial communities. However, estimating the quantitative rates of viral-induced lysis remains challenging in situ. The modified dilution method is the most commonly utilised empirical approach to estimate…
Kwame Boamah-Addo, Robert E. Gaunt, Andrey Sarantsev
In this note, we consider the performance of the classic method of moments for parameter estimation of symmetric variance-gamma (generalized Laplace) distributions. We do this through both theoretical analysis (multivariate delta method) and a comprehensive simulation study with comparison to maximum likelihood…
Kensuke Tanioka, Kaoru Okuda, Satoru Hiwa, Tomoyuki Hiroyasu
In randomized clinical trials, we assumed the situation that the new treatment is not adequate compared to the control treatment as result. However, it is unknown if the new treatment is ineffective for all patients or if it is effective for only a subgroup of patients with specific characteristics. If such a subgroup…
Pei-Chang Guo
When studying the multilinear PageRank problem, a system of polynomial equations needs to be solved. In this paper, we develop convergence theory for a modified Newton method in a particular parameter regime. The sequence of vectors produced by Newton-like method is monotonically increasing and converges to the…
Jianming Liu, Chaoqun Liu
In this paper, a modified normalized Rortex/vortex identification method named Ω� is presented to improve the original Ω method and cure the bulging phenomenon on the iso-surfaces caused by the original Ω method. Detailed mathematical explanations and the relationship with the criterion are described. In addition, the…
Nikita Zvonarev, Nina Golyandina
The paper is devoted to the solution of a weighted nonlinear least squares problem for low-rank signal estimation, which is related to Hankel structured low-rank approximation problems. A modified weighted Gauss-Newton method (MGN), which uses projection on the image space of the signal, is proposed to solve this…
Do Y. Kwak, Ju Ho Lee
In recent years, the immersed finite element methods (IFEM) introduced in [20], [21] to solve elliptic problems having an interface in the domain due to the discontinuity of coefficients are getting more attentions of researchers because of their simplicity and efficiency. Unlike the conventional finite element…
Zlatinka I. Dimitrova
We discuss the relation between the modified method of simplest equation and the exp-function method. First on the basis of our experience from the application of the method of simplest equation we generalize the exp-function ansatz. Then we apply the ansatz for obtaining exact solutions for members of a class of…
Dave Palis, Frank Huang
Mutagenesis is a process used to generate the modified DNA sequences either by mutating, insertion, substitution, and/or deletion of codons. Mutagenesis is an effective means to introduce the changes to a protein, which is important for its mechanistic and functional studies. A variety of methods have been developed to…
Chelsea K. L. Gordon, Diana Wu, Trevor A. Feagin, Anusha Pusuluri + 5 more
Base-modified aptamers that incorporate non-natural chemical moieties can achieve greatly improved affinity and specificity relative to natural DNA or RNA aptamers. However, conventional methods for generating base-modified aptamers require considerable expertise and resources. In this work, we have accelerated and…
Marcello D’Abbicco, Sandra Lucente
with a(t) > 0, b(t) > 0, f(t, x) > 0 and p > 1. Recently a big effort has been done for proving global existence for (1). In small data context this means to find an exponent pC such that the local-intime solution can be extended to a global one, for any p > pC. One may ask if this exponent pC is critical, that is, if…
Alexandra Paul, Mario Falsaperna, Helen Lavender, Michelle Garrett + 1 more
The chemistry of aptamers is largely limited to natural nucleotides, and although modifications of nucleic acids can enhance target aptamer affinity, there has not been a technology for selecting the right modifications in the right locations because enzymatic amplification does not transmit sequence-specific…
Andrew D. Bailey, Jason Talkish, Hongxu Ding, Haller Igel + 4 more
Nucleotides in RNA and DNA are chemically modified by numerous enzymes that alter their function. Eukaryotic ribosomal RNA (rRNA) is modified at more than 100 locations, particularly at highly conserved and functionally important nucleotides. During ribosome biogenesis, modifications are added at various stages of…
Shunsuke Yamazaki, Kazutoshi Takahashi, Yutaka Matsuda
This study delves into the functional intricacies of lipoate ligase A (LplA), an enzyme showing great promise in bioconjugation due to its unique capacity for introducing azido groups into proteins without requiring a genetic tag. We aimed to enhance the understanding of LplA's functionality, particularly its substrate…
Authors not listed
The diffusion of CO2 and H2O in CALF-20 was examined at various concentrations and in N2 and He carrier gases. The data show that N2 has a measurable impact on the diffusion of CO2 and H2O in the pores of CALF-20. The results highlight the importance of considering N2 adsorption in CO2 capture materials and the effect…
Kamila Maldonado, Karitza Díaz-González, Sourav Seth, Carlos Crespo-Hernández
In this study, we calculated the vertical excitation energies (VEEs) and spin-orbit coupling constants (SOCs) of 5-(thiophen-2-yl)-6-aza uracil (TAU) and 2-methyl-5-(thiophen-2-yl)-6-aza uracil (MTAU) using ground-state optimized geometries in two solvents: acetonitrile and water. We then compared the theoretical and…
Sukanya Sasmal, Samuel C. Gill, Nathan M. Lim, David Mobley
Flexible ligands often have multiple binding modes or bound conformations that differ by rotation of a portion of the molecule around internal rotatable bonds. Knowledge of these binding modes is important for understanding the interactions stabilizing the ligand in the binding pocket, and also for calculating accurate…
Authors not listed
Nature employs proteins as molecular machines to orchestrate numerous intricate biological processes. Natural proteins are primarily synthesized from 22 proteinogenic amino acids. In principle, developing abiotic proteins with novel non-proteinogenic residues can expand their functional space, enabling the discovery of…
Authors not listed
M13 bacteriophages (in short, phages) have an intrinsic ability to infect Escherichia coli bacteria but can be engineered to exhibit specific peptides on their surface which enables them to selectively bind to diverse targets. Therefore, such phages can be used as a sensing element in a biosensor. Consequently, our aim…